TP53 deletion as an MRD-dependent risk factor in childhood B-ALL: a post hoc analysis from a prospective cohort
XIAOFAN ZHU,
Yangyang Gao,
Jun Li
et al.
Abstract:The effect of TP53 alterations on childhood B-cell acute lymphoblastic leukemia (B-ALL) remains unclear. To investigate the impact of TP53 deletion (TP53del) and TP53 mutation (TP53mut) on prognosis, this post-hoc study used fluorescence in situ hybridization test to detect TP53del in 914 newly diagnosed B-ALL children from a prospective Chinese Children’s Cancer Group ALL-2015 cohort. Targeted gene sequencing was used to identify TP53mut in 345 out of the 914 patients. TP53del was detected in 4.4% of cases. T… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.