TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies

Klug, Stefanie J.; Ressing, Meike; Koenig, Jochem; Abba, Martı́n C.; Αγοραστός, Θεόδωρος; Brenna, Sylvia Michelina Fernandes; Ciotti, Marco; Das, Bibhu Ranjan; Mistro, Annarosa Del; Dybikowska, Aleksandra; Giuliano, Anna R.; Gudlevičienė, Živilė; Gyllensten, Ulf; Haws, Andrea L. Fuessel; Helland, Åslaug; Herrington, C. Simon; Hildesheim, A.; Humbey, Olivier; Jee, Sun Ha; Kim, Jae Weon; Madeleine, Margaret M.; Menczer, Joseph; Ngan, Hextan Y.S.; Nishikawa, Akira; Niwa, Yoshimitsu; Pegoraro, R.J.; Pillai, M. Radhakrishna; Ranzani, Guglielmina Nadia; Rezza, G; Rosenthal, Adam N.; Roychoudhury, Susanta; Saranath, Dhananjaya; Schmitt, Virgínia M.; Sengupta, Shamik; Settheetham-Ishida, Wannapa; Shirasawa, Hiroshi; Snijders, Peter J.F.; Stoler, Mark H.; Suarez-Rincon, Angel; Szarka, Krisztina; Tachezy, Ruth; Ueda, Masatsugu; Zee, Ate G.J. van der; Doeberitz, Magnus von Knebel; Wu, Ming-Tsang; Yamashita, Tsuyoshi; Zehbe, Ingeborg; Blettner, Maria

doi:10.1016/s1470-2045(09)70187-1

Cited by 143 publications

(116 citation statements)

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“…HPV infection was also detected in the controls indicated that not all of the HPV-infected women developed cervical cancer. Among healthy women, an HPV infection was able to clear within 1-2 years (Klug et al, 2009;Schiffman et al, 2007) and <1% of HPV-positive women would go on to develop cervical cancer (Josefsson et al, 2000;Nagpal et al, 2002). The current report indicates that the involvement of other factors such as sexual behavior, personal and partner smoking habits and genetic backgrounds are likely co-factors with HPV for an increased risk of developing cervical cancer (Settheetham-Ishida et al, 2004;Settheetham-Ishida et al, 2005;Au et al, 2007;Almonte et al, 2008).…”

Section: Discussionmentioning

confidence: 60%

“…It is now widely accepted that high risk types of human papillomavirus (HPV) (Moscicki et al, 2001;Klug et al, 2009;Carter et al, 2011), particularly HPV 16 and 18, play an important role in the genesis of cervical carcinoma (zur Hausen, 1991). Most HPV infections in the cervix spontaneously resolve and few (not all) HPV-infected females develop cervical cancer (Josefsson et al, 2000;Nagpal et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…A base substitution at codon 72 of exon 4 of gene p53 that results in either arginine (Arg; CGC) or proline (Pro; CCC) has been identified as polymorphic in human populations (Matlashewski et al, 1987;Dybikowska et al, 2000;Comar et al, 2004;Klug et al, 2009). The association of the p53 codon 72 polymorphism with an increased susceptibility for development of cancer has been examined for many sites (e.g., lung cancer (Piao et al, 2011), gastric cancer (Perez-Perez et al, 2005), and endometrial cancer (Roh et al, 2004)).…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is a serious public health problem in Thailand. We investigated possible risk factors for cervical cancer including HPV infection, p53 polymorphism, smoking and reproductive history among women in Northeast Thailand using a case control study with 177 cases and age-matched controls. Among the HPV carriers, a significantly increased risk for cervical cancer with an OR of 36.97 (p<0.001) and an adjusted OR of 38.07 (p<0.001) were observed. Early age at first sexual exposure, and multiple sexual partners increased the risk of cervical cancer with ORs ranging between 1.73-2.78 (p<0.05). The interval between menarche and first sexual intercourse <6 years resulted in a significant increase in the risk for cervical cancer with ORs ranging between 3.32-4.09 and the respective adjusted OR range for the 4-5 and 2-3 year-old groups were 4.09 and 2.92. A higher risk was observed among subjects whose partner had smoking habits, whether currently or formerly; with respective ORs of 3.36 (p<0.001) and 2.17 (p<0.05); and respective adjusted ORs of 2.90 (p<0.05) and 3.55 (p<0.05). Other smoking characteristics of the partners including smoking duration ≥ 20 years, number of cigarettes smokes ≥ 20 pack-years and exposure time of the subject to passive smoking ≥ 5 hrs per day were found to be statistically significant risks for cervical cancer with adjusted ORs of 3.75, 4.04 and 11.8, respectively. Our data suggest that the risk of cervical cancer in Thai women is substantially associated with smoking characteristics of the partner(s), the interval between menarche and first sexual intercourse as well as some other aspects of sexual behavior.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Natphopsuk

Settheetham-Ishida²,

Sinawat³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…To better understand the role of Arg72-Pro, recent meta-analysis studies have been performed for different cancer types, such as lung, 29 gastric, 30 and cervical cancer. 31 However, each of these meta-analyses is restricted to a specific tumor site. Heterogeneity is an important metaanalysis feature for assessing between-studies variation and dispersion of results.…”

mentioning

confidence: 99%

Arg72Pro TP53 polymorphism and cancer susceptibility: A comprehensive meta‐analysis of 302 case‐control studies

Francisco

Menezes

Eluf-Neto

et al. 2010

Intl Journal of Cancer

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Arg72Pro is a common polymorphism in TP53, showing differences in its biological functions. Case-control studies have been performed to elucidate the role of Arg72Pro in cancer, although the results are conflicting and heterogeneous. Here, we analyzed pooled data from case-control studies to determine the role of Arg72Pro in different cancer sites. We performed a systematic review and meta-analysis of 302 case-control studies that analyzed Arg72Pro in cancer susceptibility. Odds ratios were estimated for different tumor sites using distinct genetic models, and the heterogeneity between studies was explored using I 2 values and meta-regression. We adopted quality criteria to classify the studies. Subgroup analyses were done for tumor sites according to ethnicity, histological, and anatomical sites. Results indicated that Arg72Pro is associated with higher susceptibility to cancer in some tumor sites, mainly hepatocarcinoma. For some tumor sites, quality of studies was associated with the size of genetic association, mainly in cervical, head and neck, gastric, and lung cancer. However, study quality did not explain the observed heterogeneity substantially. Meta-regression showed that ethnicity, allelic frequency and genotyping method were responsible for a substantial part of the heterogeneity observed. Our results suggest ethnicity and histological and anatomical sites may modulate the penetrance of Arg72Pro in cancer susceptibility. This meta-analysis denotes the importance for more studies with good quality and that the covariates responsible for heterogeneity should be controlled to obtain a more conclusive response about the function of Arg72Pro in cancer.The tumor TP53 suppressor gene plays a pivotal role in protecting cells against genotoxic insults of endogenous or environmental agents, which orchestrate a diversity of pathways from transcriptional responses to apoptosis. 1,2 Although TP53 mutations are thought to be associated with carcinogenesis, 3,4 polymorphisms in TP53 seem to have a modest effect on cell phenotype, leading to different patterns of cancer susceptibility. 5 Among known TP53 polymorphisms, 6 Arg72Pro is the most studied, and in vitro assays have demonstrated a differential ability to trigger apoptosis 7 and susceptibility for degradation by the E6 protein of the HPV-16 virus. 8 However, in the epidemiologic field, even with a considerable number of reports analyzing the p53 Arg72Pro polymorphism and risk of cancer in case-control studies, results remain conflicting rather than conclusive. For breast cancer, for example, results vary from protective 9-12 to no association [13][14][15] or increase in risk. [16][17][18] Similar conflicting results are also observed for esophageal, 19-22 lung, 23-25 and colorectal cancer [26][27][28] and other cancer types. To better understand the role of Arg72-Pro, recent meta-analysis studies have been performed for different cancer types, such as lung, 29 gastric, 30 and cervical cancer. 31 However, each of these meta-analyses is restricted to a specif...

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“…Sample size was classified according to a minimum of 200 participants and those with fewer than 200 participants. The cite criteria were previously described (Klug et al, 2009). Last, sensitivity analysis was also performed, excluding studies whose allele frequencies in controls exhibited significant deviation from the Hardy-Weinberg equilibrium (HWE), given that the deviation may denote bias.…”

Section: Discussionmentioning

confidence: 99%

Four Polymorphisms in the Cytochrome P450 1A2 (CYP1A2) Gene and Lung Cancer Risk: a Meta-analysis

Ye²,

Cheng³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Previous published data on the association between CYP1A2 rs762551, rs2069514, rs2069526, and rs2470890 polymorphisms and lung cancer risk have not allowed a definite conclusion. The present metaanalysis of the literature was performed to derive a more precise estimation of the relationship. Materials and Methods: 8 publications covering 23 studies were selected for this meta-analysis, including 1,665 cases and 2,383 controls for CYP1A2 rs762551 (from 8 studies), 1,456 cases and 1,792 controls for CYP1A2 rs2069514 (from 7 studies), 657 cases and 984 controls for CYP1A2 rs2069526 (from 5 studies) and 691 cases and 968 controls for CYP1A2 rs2470890 (from 3 studies). Results: When all the eligible studies were pooled into the meta-analysis for the CYP1A2 rs762551 polymorphism, significantly increased lung cancer risk was observed in the dominant model (OR=1.21, 95 % CI=1.00-1.46). In the subgroup analysis by ethnicity, significantly increased risk of lung cancer was observed in Caucasians (dominant model: OR=1.29, 95%CI=1.11-1.51; recessive model: OR=1.33, 95%CI=1.01-1.75; additive model: OR=1.49, 95%CI=1.12-1.98). There was no evidence of significant association between lung cancer risk and CYP1A2 rs2069514, s2470890, and rs2069526 polymorphisms. Conclusions: In summary, this meta-analysis indicates that the CYP1A2 rs762551 polymorphism is linked to an increased lung cancer risk in Caucasians. Moreover, our work also points out the importance of new studies for rs2069514 associations in lung cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the rs2069514 polymorphism in lung cancer development.

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TP53 codon 72 polymorphism and cervical cancer: a pooled analysis of individual data from 49 studies

Cited by 143 publications

References 71 publications

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Risk Factors for Cervical Cancer in Northeastern Thailand: Detailed Analyses of Sexual and Smoking Behavior

Arg72Pro TP53 polymorphism and cancer susceptibility: A comprehensive meta‐analysis of 302 case‐control studies

Four Polymorphisms in the Cytochrome P450 1A2 (CYP1A2) Gene and Lung Cancer Risk: a Meta-analysis

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