Toxoplasmosis in immunocompetent Saudi women: Correlation with vitamin D

Rasheed, Zafar; Shariq, Ali; AlQefari, Ghaida B; Alwahbi, Ghayda S.; Aljuaythin, Amal I; Alsuhibani, Fidaa S; Alotaibi, Daliyah F.; Aljohani, Shahad S; Alghasham, Ruqiah; Alsaeed, Thamir; Alharbi, Nada Abdullah; Rugaie, Osamah Al; Abdulmonem, Waleed Al; Sharaf, Osama

doi:10.1177/17455065211043844

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…The conclusions in studies of the association between vitamin D levels and T. gondii antibody seroprevalence have been controversial [18]. Two studies with small sample sizes have reported that vitamin D deficiency increases the risk of T. gondii infection [18,19]. However, another study with three cohorts and a larger sample size (n=663) has rejected this hypothesis [20].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D deficiency, which is common in the general population [10,11], has been found to increase susceptibility to some infections, such as human papillomavirus, latent tuberculosis, COVID-19 and acquired immune deficiency syndrome [12][13][14][15]. In vitro and in vivo studies have demonstrated a protective role of vitamin D against T. gondii infection [16,17]; however, the results regarding the relationship between vitamin D status and T. gondii infection in humans have been contradictory [18][19][20]. The present study aimed at exploring the relationship between vitamin D levels and T. gondii infection, on the basis of a nationally representative database.…”

Section: Introductionmentioning

confidence: 99%

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Lower Vitamin D Levels are Associated with Higher Seroprevalence of Toxoplasma gondii—a US National Survey Study

Huang

Wang

et al. 2022

Zoonoses

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Objective: Vitamin D deficiency is associated with high susceptibility to infections. The present study aimed at exploring the relationship between vitamin D levels and Toxoplasma gondii (T. gondii) infection, on the basis of a nationally representative database. Methods: The study data came from the National Health and Nutrition Examination Surveys (NHANES) 2001–2004. Participants underwent both Toxoplasma IgG antibody testing and serum vitamin D testing. Vitamin D deficiency was defined by a serum 25-hydroxyvitamin D level <20 ng/mL. Multivariate logistic regression and propensity score matching were used to adjust for potential confounders. All analyses were conducted in R software. Results: A total of 10613 participants were included. Among these, 3973 (37.4%) were vitamin D deficient, and 2070 (19.5%) were seropositive for T. gondii IgG antibody. Vitamin D deficiency was found in 42.3% of the seropositive population, compared with 36.3% of the seronegative population (P<0.001). After adjustment for sex, age, body mass index, smoking history, drinking history and testing season, vitamin D deficiency was associated with an elevated risk of T. gondii infection (OR=1.303, 95% CI=1.136–1.495, P<0.001). This effect persisted in the propensity matching cohort. Conclusions: Low vitamin D levels are associated with high seroprevalence of T. gondii.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lower Vitamin D Levels are Associated with Higher Seroprevalence of Toxoplasma gondii—a US National Survey Study

Huang

Wang

et al. 2022

Zoonoses

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“…Toxoplasmosis has been correlated with many diseases 5 . A study detected vitamin D deficiency during acute toxoplasmosis episodes 6 . Another study found a correlation between the rising titer of Toxoplasma IgG and levels of vitamin D 6 .…”

Section: Introductionmentioning

confidence: 99%

“…A study detected vitamin D deficiency during acute toxoplasmosis episodes 6 . Another study found a correlation between the rising titer of Toxoplasma IgG and levels of vitamin D 6 . Regarding rubella, one study detected no correlation between vitamin D and rubella 7 .…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii, Rubella, Group A Streptococcus, CMV and HSV-1 in COVID-19 Patients with Vitamin D Deficiency

Halawi¹,

Al-Hazmi²,

Aljuaid³

et al. 2021

Pakistan J. of Biological Sciences

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Background and Objective: In recent years, respiratory tract viral infections have caused many pandemics that impact the whole world.To investigate the seropositivity of Toxoplasma gondii, rubella, CMV, HSV-1 and group A Streptococcus in recovered COVID-19 patients and correlate these findings with vitamin D levels. Materials and Methods: A total of 417 COVID-19 patients with diarrhoea were enrolled in this study. Vitamin D and seroprevalence for Toxoplasma gondii, rubella, CMV, HSV-1 and group A Streptococcus were evaluated and correlated. Results: It was found that recent infection in COVID-19 patients with HSV-1, rubella, Toxoplasma and CMV, respectively. IgG was detected indicating the development of adaptive immunity with all microbes. Conclusion: Current study detected a correlation between vitamin D levels and HSV-1 and no correlation between this infection and vitamin D deficiency with the other microbes.

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Inverted U-shaped relationship between serum 25-hydroxyvitamin D concentrations and Toxoplasma gondii infection: a cross-sectional study

Huang,

Luo,

et al. 2024

Front. Public Health

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BackgroundToxoplasma gondii (T. gondii) is a widespread zoonotic parasite transmitted through contaminated food or water. It poses a significant public health threat, especially to pregnant women and immunocompromised individuals. 25-Hydroxyvitamin D [25(OH)D] plays a critical role in regulating both innate and adaptive immune responses, particularly in its anti-infective capacity. However, the relationship between serum 25(OH)D concentrations and T. gondii infection remains uncertain.MethodsWe analyzed the data from the National Health and Nutrition Examination Survey (NHANES) spanning 2009–2014 to explore the association between serum 25(OH)D concentrations and T. gondii infection. Extensive demographic, comorbidity, and dietary data were collected. The status of T. gondii infection was determined using serum anti-IgG antibodies. Serum 25(OH)D levels were measured using ultra-high performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). In addition, weighted logistic regression and restricted cubic spline analyses were performed.ResultsOur analysis included 10,157 participants (mean [SE] age, 45.38 [0.39] years; 49.73% female) who met the inclusion criteria. Serum 25(OH)D levels were categorized into quintiles, with the second quintile serving as the reference group. The final model, adjusted for age, sex, race, education level, poverty income ratio, body mass index, smoking status, hypertension, diabetes, chronic kidney disease, depression, physical activity, alcohol intake, seasonal testing, and dietary vitamin D, revealed the following adjusted odds ratios (ORs) for the quintiles: 0.75 (95% confidence interval [CI]: 0.60–0.93) for the first, 0.87 (95% CI: 0.69–1.10) for the third, 0.75 (95% CI: 0.58–0.95) for the fourth, and 0.66 (95% CI: 0.49–0.91) for the fifth. Additionally, a restricted cubic spline analysis revealed an inverted U-shaped relationship between serum 25(OH)D and T. gondii infection, with an inflection point at approximately 51.29 nmol/L. Odds ratios to the left and right of the inflection point were 1.17 (95% CI: 1.03–1.32) and 0.94 (95% CI, 0.90–0.98) per 10 nmol/L, respectively.ConclusionOur study uncovers an inverted U-shaped relationship between serum 25(OH)D concentrations and T. gondii infection, with an inflection point around 51.29 nmol/L.

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Toxoplasmosis in immunocompetent Saudi women: Correlation with vitamin D

Cited by 3 publications

References 35 publications

Lower Vitamin D Levels are Associated with Higher Seroprevalence of Toxoplasma gondii—a US National Survey Study

Lower Vitamin D Levels are Associated with Higher Seroprevalence of Toxoplasma gondii—a US National Survey Study

Seroprevalence of Toxoplasma gondii, Rubella, Group A Streptococcus, CMV and HSV-1 in COVID-19 Patients with Vitamin D Deficiency

Inverted U-shaped relationship between serum 25-hydroxyvitamin D concentrations and Toxoplasma gondii infection: a cross-sectional study

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