Toxoplasmosis Among Patients with Immunocompromising Conditions: A Snapshot

Abdoli, Amir; Barati, Mohammad; Dalimi, Abdolhossein; Pirestani, Majid; Shokouh, Seyyed Javad Hoseini

doi:10.5812/jamm.41832

Cited by 16 publications

(24 citation statements)

References 16 publications

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“…1 A host's immunological status is the most important influencing factor in the course of T. gondii infection. 2 The infection is usually asymptomatic (albeit, latent) in immunocompetent individuals but is life-threatening in immunocompromised patients, including cancer patients, especially during chemotherapy. [2][3][4][5][6] The reactivation of latent toxoplasmosis may also arise in infection in immunocompromised patients.…”

Section: Introductionmentioning

confidence: 99%

Screening of toxoplasmosis in cancer patients: a concern

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Screening of toxoplasmosis in cancer patients: a concern

et al. 2018

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“…More than one-third of the world human populations are T. gondii-IgG seropositive without any clinical symptoms (Robert-Gangneux & Darde, 2012). In fact, toxoplasmosis is usually asymptomatic in healthy individuals, but it always life threatening in immunocompromised patients (e.g., HIV/ AIDS, cancer, transplant recipients, and hemodialysis patients) (Abdoli et al, 2016;Robert-Gangneux & Darde, 2012). Hence, immunocompromised patients are presented as sensitive groups of toxoplasmosis and the infection is usually higher prevalent among these patients than healthy individuals (Abdoli et al, 2016;Robert-Gangneux & Darde, 2012).…”

Section: Dear Editormentioning

confidence: 99%

“…In fact, toxoplasmosis is usually asymptomatic in healthy individuals, but it always life threatening in immunocompromised patients (e.g., HIV/ AIDS, cancer, transplant recipients, and hemodialysis patients) (Abdoli et al, 2016;Robert-Gangneux & Darde, 2012). Hence, immunocompromised patients are presented as sensitive groups of toxoplasmosis and the infection is usually higher prevalent among these patients than healthy individuals (Abdoli et al, 2016;Robert-Gangneux & Darde, 2012). Surprisingly, the molecular results of Menati Rashno et al is inconsistence with the other reports, even in comparison with studies that detected toxoplasmosis in immunocompromised patients.…”

Section: Dear Editormentioning

confidence: 99%

Toxoplasma gondii infection in patients with Alzheimer's disease and healthy individuals: strange molecular results

Abdoli

2017

Int J Geriat Psychiatry

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“…The disease is dangerous for immunocompromised individuals such as those treated with immunosuppressive drugs, HIVpositive patients, cancer patients, etc. (7,8).…”

Section: Introductionmentioning

confidence: 99%

Anti-Toxoplasma Effects of Silver Nanoparticles Based on Ginger Extract: An in Vitro Study

et al. 2020

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Background: Toxoplasmosis is a tropical disease that is opportunistic in immunocompromised patients. Objectives: In this research, our goal was to assess the anti-parasitic effect of silver nanoparticles (Ag-NPs) based on ginger extract on T. gondii tachyzoites. Methods: This study was conducted to assess the effects of various concentrations of nanoparticles on the parasite using light microscopy. The MTT assay was also conducted to evaluate the toxic effects of silver nanoparticles based on ginger extract on macrophage cells. In addition, the potential apoptosis of T. gondii by silver NPs was assessed using the flow cytometry technique. Results: Based on the tachyzoite assay using microscopic examination, it was observed that the higher the NPs concentration and the longer the parasite’s exposure to NPs, the greater the lethal effect of NPs on tachyzoites. The IC50 (inhibitory concentration) for NPs against T. gondii tachyzoites was 2 ppm. Also, according to the MTT assay, the 40 ppm concentration of nanoparticles had the most toxic impact on macrophages. Moreover, silver NPs led to apoptosis in approximately 55.22% of tachyzoites based on the flow cytometry technique. Conclusions: Based on the above results, it is concluded that silver nanoparticles based on ginger extract have a lethal effect on T. gondii and induce apoptosis in this parasite. This study encourages further studies in vivo.

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Toxoplasmosis Among Patients with Immunocompromising Conditions: A Snapshot

Cited by 16 publications

References 16 publications

Screening of toxoplasmosis in cancer patients: a concern

Screening of toxoplasmosis in cancer patients: a concern

Toxoplasma gondii infection in patients with Alzheimer's disease and healthy individuals: strange molecular results

Anti-Toxoplasma Effects of Silver Nanoparticles Based on Ginger Extract: An in Vitro Study

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