Toxoplasmosis accelerates acquisition of epilepsy in rats undergoing chemical kindling

Babaie, Jalal; Sayyah, Mohammad; Choopani, Samira; Asgari, Tara; Golkar, Majid; Gharagozli, Kurosh

doi:10.1016/j.eplepsyres.2017.06.012

Cited by 11 publications

(16 citation statements)

References 25 publications

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“…Moreover, the T. gondii cysts are abundantly found in the brains of mice but infrequently found in the brains of rats . In agreement, the rat brain has a lower risk of T. gondii infection, with no visible histological damage . Compared to rats, the learning capacity of mice is much more conspicuously retarded by a T. gondii infection .…”

Section: Introductionmentioning

confidence: 60%

“…Compared to type I stains, types II and III strains are less virulent to mice, and the infective doses of those strains are significantly higher for rats than for mice, irrespective of the administration routes . Moreover, the T. gondii cysts are abundantly found in the brains of mice but infrequently found in the brains of rats . In agreement, the rat brain has a lower risk of T. gondii infection, with no visible histological damage .…”

Section: Introductionmentioning

confidence: 71%

“…Upon infection, the parasites persist as intraneuronal cysts in the CNS for the lifetime of the host . Interestingly, the T. gondii cysts are more frequently found in the brain of mice than in the brain of rats . The control of cysts depends on the immune system of hosts, and the ongoing inflammation is required to control T. gondii in chronic cerebral infection .…”

Section: Resultsmentioning

confidence: 99%

“…When both hosts are given the same inoculum, tissue cysts in brains of rats are of the same size as in mice . In the aspect of brain cyst number, the T. gondii cysts are abundantly found in the brain of mice but less frequently found in the brain of rats . According to research on the reactivation of latent infection, T. gondii tachyzoites are present in the brains of chronically infected mice but the frequency of the phenomenon is unknown .…”

Section: Discussionmentioning

confidence: 99%

“…Instead, in experimentally infected rats, tissue cyst rupture was frequent, but there was no evidence for reactivation and the presence of tachyzoites . Moreover, the rats have lower brain infestation and no visible histological damages . These phenomena of T. gondii infection brought us to consider what differences exist between rat and mouse brain.…”

Section: Discussionmentioning

confidence: 99%

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A Double‐Edged Sword: Complement Component 3 in Toxoplasma gondii Infection

et al. 2019

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Sprague Dawley rats and Kunming (KM) mice are artificially infected with type II Toxoplasma gondii strain Prugniaud (Pru) to generate toxoplasmosis, which is a fatal disease mediated by T. gondii invasion of the central nervous system (CNS) by unknown mechanisms. The aim is to explore the mechanism of differential susceptibility of mice and rats to T. gondii infection. Therefore, a strategy of isobaric tags for relative and absolute quantitation (iTRAQ) is established to identify differentially expressed proteins (DEPs) in the rats’ and the mice's brains compared to the healthy groups. In KM mice, which is susceptible to T. gondii infection, complement component 3 (C3) is upregulated and the tight junction (TJ) pathway shows a disorder. It is presumed that T. gondii‐stimulated C3 disrupts the TJ of the blood–brain barrier in the CNS. This effect allows more T. gondii passing to the brain through the intercellular space.

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Section: Introductionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 71%