Toxoplasma lymphadenitis mimicking malign axillary lymphadenopathy of a left breast mass

Demiray, Emine Kübra Dindar; Bostancı, Hasan; Yılmaz, Engin; Kutluer, Nizamettin; Kargıcı, Hülagü

doi:10.1007/s13304-012-0135-6

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Lymphadenopathy is a common clinical manifestation of both breast cancer and toxoplasmosis [59]. In this regard, several cases of toxoplasmic lymphadenitis have been detected in axillary lymph nodes that mimic malignancy [21,[60][61][62][63].…”

Section: Discussionmentioning

confidence: 99%

Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran

Haghbin

Maani

Bagherzadeh

et al. 2023

International Journal of Breast Cancer

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Objective. Reactivation of latent toxoplasmosis is the main cause of severe infection among immunocompromised patients, including patients with cancer. Hence, this study is aimed at screening the status of Toxoplasma gondii infection among breast cancer patients by serological and molecular methods and determining their associated risk factors in Jahrom County, Fars Province, south of Iran. Methods. One hundred and seven women with breast cancer (aged 34 to 80 years) were screened for anti-T. gondii antibodies (IgG and IgM) during 2019–2020. A questionnaire regarding demographic factors was filled out by participants. Molecular detection was performed by polymerase chain reaction (PCR) using the primer pair targeting the repetitive element (RE) gene of T. gondii. The risk factors and demographic data were analyzed by SPSS software (ver. 20, Chicago, IL, USA) using the Chi-squared test. Results. Anti-T. gondii IgG was detected in 45.8% (49/107) of the patients, which indicates latent infection, but anti-T. gondii IgM and PCR were negative in all samples. Demographic factors revealed a statistically significant increased T. gondii seropositivity among nonmenopause cancer patients ( P < 0.0005 ), patients without previous breast cancer ( P = 0.0001 ), and human epidermal growth factor receptor 2- (HER2-) negative patients ( P = 0.00002 ). As such, patients with a history of previous abortions and who were at stages II, III, and IIII of cancer had higher seropositivity rates than patients without a history of previous abortions or who were at stage I cancer, but the statistical analysis was not significant. We did not find a statistically significant association between T. gondii seropositivity and other risk factors of toxoplasmosis (e.g., education level, type of water source, washing raw fruits and vegetables, consumption of raw or undercooked meat, and contact with soil, cats, and domestic animal). Conclusion. A high seroprevalence rate of latent T. gondii infection was detected among patients with breast cancer; hence, these patients may be at high risk for reactivation of latent infection. Screening of T. gondii infection is recommended to detect active infection among patients with malignancies.

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Section: Discussionmentioning

confidence: 99%

Latent Toxoplasmosis among Breast Cancer Patients in Jahrom, South of Iran

Haghbin

Maani

Bagherzadeh

et al. 2023

International Journal of Breast Cancer

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“…Follicles are large and irregular with active germinal centers containing many tingible body macrophages. Scattered collections of pale staining parafollicular monocytoid B cells and small clusters of epithelioid histiocytes forming small granulomas are the most distinct features of toxoplasmic lymphadenitis [16]. The granulomas are smaller and less sharply defined than in sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Acute Toxoplasmosis Mimicking Melanoma Metastases: Review of Conditions Causing False-Positive Results on <sup>18</sup>F-FDG PET/CT

Ivanova

Glatz²,

Zippelius³

et al. 2012

Dermatology

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Invasive malignant melanoma is the most common fatal form of skin cancer. Fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography demonstrates a very high sensitivity and specificity for the detection of melanoma metastases. Here, we report an unusual case of toxoplasma lymphadenitis in a male adult patient mimicking a malignant cervical lymphadenopathy. Toxoplasmosis is a zoonosis caused by the intracellular parasite Toxoplasma gondii, which is usually asymptomatic in immunocompetent hosts.

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“…Other causes of axillary adenopathy include sarcoidosis and drug reaction [3,6]. Toxoplamosis presenting as unilateral axillary adenopathy is rare with only three case reports published to the knowledge of the authors [7][8][9].…”

Section: Discussionmentioning

confidence: 99%