Toxoplasma gondii

SUMMARYThe concomitance of nephrotic syndrome and acute infection by Toxoplasma gondii is a rare occurrence in humans. In this paper seven cases of children, ranging from 11 months to 7 year-old, with concomitant nephrotic syndrome and asymptomatic acute T. gondii infection are reported. In one of those patients only the administration of anti-Toxoplasma therapy was enough to control the clinical and laboratory manifestations of the disease. In the other patients it was necessary to introduce corticosteroids or other immunosuppressant drugs. Three patients had complete clinical and laboratory improvement and the remaining showed only a partial response.

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“…However, the occurrence of nephrotic syndrome in an adult immunocompetent woman after infection with T. gondii has already been reported 10 .…”

Section: Discussionmentioning

confidence: 99%

“…Infection with T. gondii can assume serious aspects when it occurs either in the congenital form or in immunosuppressed patients 10 . In immunocompetent individuals, when transmission occurs after birth, toxoplasmosis commonly has asymptomatic or oligosymptomatic courses.…”

Section: Introductionmentioning

confidence: 99%

Nephrotic syndrome associated with toxoplasmosis: report of seven cases

Toporovski

Romano

Hartmann

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…The incubation period is 5-23 days after ingesting the cysts. The infected women are usually asymptomatic, and during pregnancy, she may undergo pregnancy loss, stillbirth, and intrauterine malformations in the fetus [4,5].…”

mentioning

confidence: 99%

Seroprevalence and Influence of Torch Infections in High Risk Pregnant Women: A Large Study from South India

Prasoona

Buragadda

Sunitha

et al. 2014

J Obstet Gynecol India

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Background The increased complications to the mother and fetus during or after pregnancy and birth are often caused by a wide array of pathogenic organisms mostly belonging to the TORCH group [toxoplasmosis, rubella, cytomegalovirus (CMV), and herpes simplex virus (HSV)]. These agents cause asymptomatic or mild infection in the mother while serious consequences in fetus. The present study was aimed to find significant etiological pathogens in the causation of high risk pregnancy (HRP) in South Indian population. Material and Methods A total of 1, 158 HRP women (2010158 HRP women ( -2013 from Modern Government Maternity Hospital, Hyderabad were considered. Two milliliter of blood was obtained and the serum was analyzed for IgG and IgM antibodies against TORCH agents by ELISA. Results Twenty-five percent of the study group had fetal congenital malformation in the present pregnancy (Group 1; N = 291) while 75 % showed bad obstetric history (BOH) (Group 2; N = 867). Maternal age of B25 years, primi gravida, and consanguinity showed predisposing role for Group 1 while maternal age C30 years and C 3 gravida were contributing risk for Group 2. The seropositvity in 123HRP women for toxoplasma, rubella, CMV, and HSV was 28, 84, 92, and 61 %, respectively for IgG while it was 6, 3, 4, and 3 % for IgG ? IgM. Total seropositvity of toxoplasma, rubella, CMV, and HSV in Group 1 was 29, 97, 97, and 62 % while it was 36, 84, 97, and 65 % in Group 2, respectively. Conclusion Maternal age of B25 years, primi gravida, and consanguinity contributed to fetal congenital malformation in the present pregnancy while maternal age of C30 years and C 3 gravida towards BOH. Toxoplasma is protective while rubella and CMV are the infectious agents for HRP. Among the groups, toxoplasma and rubella conferred a predisposing risk towards Group 2 and Group 1, respectively. Sixty-one percent seropositvity of HSV in relation to bad obstetric outcome is the highest prevalence reported so far in India.

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“…Hastalık, klinik veya radyolojik olarak yaygın veya tedavinin altıncı haftasında tedaviye yanıt tam değilse tedavi süresi uzatılabilir. TE nedeniyle tedavi edilen tüm HIV ile enfekte hastalara sekonder profilaksi uygulanır (4,5).…”

Section: Introductionunclassified