Toxoplasma gondii-specific IgG avidity testing in pregnant women

Garnaud, Cécile; Fricker‐Hidalgo, Hélène; Evengård, Birgitta; Álvarez-Martínez, Míriam J.; Petersen, Eskild; Kortbeek, L. M.; Robert‐Gangneux, Florence; Villena, Isabelle; Costache, Carmen; Paul, Małgorzata; Meroni, Valeria; Guy, Edward; Chiodini, Peter L.; Brenier-Pinchart, Marie-Pierre; Pelloux, H

doi:10.1016/j.cmi.2020.04.014

Cited by 26 publications

(24 citation statements)

References 43 publications

(70 reference statements)

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“…It is recommended to use the avidity test of TXP‐specific IgG antibodies to date the timing of infection when IgM and IgG antibodies are positive during the first trimester. The presence of a high avidity indicates that the infection happened at least 3–5 months earlier 6 . In the case of our patient, who was tested at 6 WG, the avidity was high meaning that the primary infection occurred at least 2 months prior conception and that the risk of congenital infection was supposed to be extremely low.…”

Section: Discussionmentioning

confidence: 63%

Congenital toxoplasmosis after adalimumab treatment before pregnancy

Krull

Taraschi

Amari³

et al. 2021

J of Obstet and Gynaecol

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We present a case of congenital toxoplasmosis (TXP) in a woman with Toxoplasma gondii infection more than 6 months before conception. The woman has been treated with adalimumab for ankylosing spondylitis for 4 years until 5 months before conception. TXP serology at the first trimester was compatible with infection prior pregnancy. An ultrasound performed at 26 weeks gestation (WG) showed cerebral echogenic lesions compatible with intrauterine infection. Amniocentesis was performed which confirmed TXP fetal infection. Termination of the pregnancy was performed upon parent's requests and the fetal autopsy confirmed the diagnosis. Here, we discuss the potential role of immunosuppressive treatments, such as adalimumab, in the risk of congenital toxoplasmosis and the importance of counseling before pregnancy.

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Section: Discussionmentioning

confidence: 63%

Congenital toxoplasmosis after adalimumab treatment before pregnancy

Krull

Taraschi

Amari³

et al. 2021

J of Obstet and Gynaecol

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“…[25,31] As a result, for the differentiation between recent and old T. gondii infections, an IgG avidity test is highly recommended. [14] This study showed that the results of follow up of certain cases of pregnant women which were seropositive for anti-Toxoplasma Abs during their pregnancy. Which were 34 seropositive pregnant women, 15 of them delivered healthy babies, concerning miscarriages nine cases had miscarriages.…”

Section: Discussionmentioning

confidence: 79%

Serodiagnosis Of Toxoplasmosis By Using ELISA And IgG Avidity Test In Relation To Some Risk Factors Among Women at Childbearing Agein Zakho City, Duhok Province/Iraq.

Sultan¹,

Mero²

2021

Al-Qadisiyah Journal of Pure Science

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This study intended to evaluate the seroprevalence of anti-Toxoplasma IgG and IgM antibodies in the sera of 630 women at childbearing age, and to link the outcomes with some risk factors. The enrolled women visited Zakho Maternity Hospital from July 2018 to July 2019. Their ages ranged from 15 to 45 years. All samples were examined using ELISA to detect immunoglobulin G and M, in addition to performing IgG Avidity test for seropositive pregnant women. The differences between seropositivity and age was significant (p<0.05), the highest rate (20.43%) for anti-Toxoplasma IgG antibodies in the age group 33-38 years. Women who had more contact with cats showed higher IgG and IgM seropositivity rates (16.45% and 1.26%, respectively). Married women had higher IgG Abs seropositivity than single ones (12.52% vs 6.31%, respectively), moreover, only married women were seropositive for IgM Abs. Pregnant women presented higher IgG Abs seropositivity than non-pregnant (15.21% versus 10.49%), with almost equal seropositivity for IgM Abs (0.65% and 0.86%, respectively). Anti-Toxoplasma IgG Abs seropositivity was higher in women underwent miscarriages than those with normal pregnancies (18.44 vs. 8.81%), however IgM Abs was only found among women who had miscarriages (0.97%). Women with triple miscarriages presented the highest IgG Abs seropositivity (37.03%). Chronic infection was found in 68.75% of pregnant women, whereas acute infection was found in 31.25 %. Following up the pregnancy resulted in 15 healthy births, 9 miscarriages, and 10 women did not show up. The findings of this study demonstrate the relationship between toxoplasmosis and risk factors in women at childbearing age, with the aim of decreasing infection rates through the health education and application of hygienic measures.

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“…2). Toxoplasma gondii -specific IgG avidity testing is an essential tool in establishing this in the immunocompetent host (28).…”

Section: Discussionmentioning

confidence: 99%