Toxoplasma gondii, Mental Health and Shizophrenia

Cevızcı, Sibel; Babaoğlu, Ülken Tunga; Öyekçin, Demet Güleç

doi:10.5455/pmb.1-1337514352

Cited by 3 publications

(2 citation statements)

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“…6 Although there are a large number of studies on neurological disorders and cancer association with T. gondii, there is a minimal number of studies on the relationship with diabetes. 7,8 Cellular immunity plays a role in the basis of the immune response of the host to T. gondii. T. gondii creates a dominant Thelper type 1 (Th1) cell-mediated inflammatory response.…”

Section: Introductionmentioning

confidence: 99%

Detection of Toxoplasma gondii infection among diabetic patients in Turkey

Özçelık

Alim

Ozpinar

2020

Clinical Epidemiology and Global Health

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A B S T R A C TBackgound: In some recent studies, it has been suggested that there may be a relationship between Toxoplasma gondii (T. gondii) and type 2 diabetes mellitus (T2DM). T. gondii is of greater significance in these patients.Objectives: In the present study, it was aimed to investigate the seroprevalence of T. gondii in T2DM patients. Methods: To define Toxoplasma IgG and IgM seropositivity and determine the seroprevalence of toxoplasmosis in patients presenting at the Internal Diseases outpatient clinic of the Healthcare Application and Research Hospital, where the ELISA method was used. 200 T2DM patients and 100 healthy individuals with no complaints took part in the study. Results: Toxoplasma IgG positivity was determined in 53% of the 200 T2DM patients and Toxoplasma IgM positivity in 13%. While in the control group, Toxoplasma IgG positivity was determined in 27% and Toxoplasma IgM positivity in 1%. The risk of toxoplasmosis infection in T2DM patients was two folds higher than healthy controls according to the IgG results. IgM results were further differentiated. Conclusions: We believe that the seroprevalence of T. gondii is high in the T2DM patient group and that the causes should be investigated in more detail.

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Section: Introductionmentioning

confidence: 99%

Detection of Toxoplasma gondii infection among diabetic patients in Turkey

Özçelık

Alim

Ozpinar

2020

Clinical Epidemiology and Global Health

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“…As in many countries, studies in Turkey are continuing. There are studies on seroprevalence of toxoplasmosis and schizophrenia reported from the University and State Hospital in our research area Canakkale [105][106][107][108].…”

Section: Toxoplasmosis and Pregnancymentioning

confidence: 99%

Toxoplasmosis and Public Health Genomics

Oymak¹,

Merve²,

Sevilay³

et al. 2017

Toxoplasmosis

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Toxoplasma gondii infection generally causes flu-like symptoms in healthy individuals; however, immunosuppression of the infected individual causes reactivation of the pathogen to its active form and relapse of the toxoplasmosis. Today it is known that toxoplasmosis triggers psychiatric disorders such as schizophrenia as well as behavioral changes such as suicide attempts. Although dermatological manifestations are very rare, the dermatological lesions are not unique. In addition, previous toxoplasma infection also causes congenital infections because of placental infection and causes birth defects and spontaneous abortion. T. gondii strains are mainly divided into three main clonal lineages, yet higher recombination rate causes unusual population structure and heterogeneous distribution of the pathogen. Both genetic variations, of the pathogen and the patients, are important for virulence property and success of the therapies. The scientist focuses on the genetic variations of the pathogens and individuals to achieve effective treatment and developed tailor-made medicines. Thus, understanding the molecular basis of the disease and the link of molecular mechanism with host immunity is important to fully know the disease and related disorders. In this chapter, we would like to evaluate the current knowledge on genetic, molecular characteristics of toxoplasmosis in view of public health genomics.

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A Global Problem of Toxoplasmosis

Çakır-Koç

Özdemir

2018

The Microbiology of Central Nervous System Infections

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Toxoplasma gondii, Mental Health and Shizophrenia

Cited by 3 publications

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Detection of Toxoplasma gondii infection among diabetic patients in Turkey

Detection of Toxoplasma gondii infection among diabetic patients in Turkey

Toxoplasmosis and Public Health Genomics

A Global Problem of Toxoplasmosis

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