“…TgPRMT1, on the other hand, localizes primarily to the cytosol and pericentriolar regions and ensures correct segre- 1 The abbreviations used are: PRMTs, protein arginine methyltransferases; ApiAP2, Apicomplexan Apetala 2 transcription factors; Arg, arginine (R); cdpk, calcium dependent protein kinase; CARM1, coactivator-associated arginine methyltransferase 1; Cys, cysteine (C); DUF, domain of unknown function; EXTRA, extracellular; FDR, false discovery rate; GO, Gene Ontology; GAR, glycine-arginine; H3R2me2, histone 3 dimethyl arginine 2; H4R3me2, histone 4 dimethyl arginine 3; HFF, human foreskin fibroblasts; JMJD6, jumonji domain-containing protein 6; KEGG, Kyoto Encyclopedia of Genes and Genomes; Lys, lysine (L); MGF, mascot generic format; Met, methionine (M); MMA, monomethyl arginine; ADMA, NG-NG-asymmetric dimethylarginine; SDMA, omega NG-NG-symmetric dimethylarginine; PADIs, peptidyl arginine deiminases; PBS, phosphate buffered saline; PTM, post translational modification; PRMT1COMP, PRMT1 complemented T. gondii strain; PRMT1KO, PRMT1 knockout T. gondii strain; RBD, RNA binding domain; RBP, RNA binding proteins; RRM, RNA Recognition Motif; STY, serine threonine tyrosine; SPT6, suppressor of Ty 6; Trp, tryptophan (W); Tyr, tyrosine (Y); WT, wild type. gation of daughter cells during parasite replication (29). Like human PRMT1 (20), TgPRMT1 is not essential to viability, however deletion of TgPRMT1 results in loss of synchronous replication and a disrupted cell cycle, along with changes in gene expression (29).…”