Toxoplasma gondii activates NLRP12 inflammasome pathway in the BALB/c murine model

Rajabi, Saba; Spotin, Adel; Mahami-Oskouei, Mahmoud; Baradaran, Behzad; Babaie, Farhad; Azadi, Yaghob; Alizadeh, Paria; Valadan, Reza; Barać, Aleksandra; Ahmadpour, Ehsan

doi:10.1016/j.actatropica.2021.106202

Cited by 7 publications

(2 citation statements)

References 32 publications

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“…In addition, the intracellular ROS levels in tachyzoite-injected mice were significantly higher than in control mice. These results suggest that T. gondii infection may activate the NLRP12 inflammasome and increase the expression of proinflammatory cytokines such as IL-1β and IL-18 and activates the pyroptosis pathway ( 51 ).…”

Section: The Function Of Other Nlr Families In T Gondii ...mentioning

confidence: 99%

The strategies of NLRP3 inflammasome to combat Toxoplasma gondii

Yoon¹,

Ham²,

Gil³

et al. 2022

Front. Immunol.

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Infection with the protozoan parasite Toxoplasma gondii (T. gondii) results in the activation of nucleotide-binding domain leucine-rich repeat containing receptors (NLRs), which in turn leads to inflammasome assembly and the subsequent activation of caspase-1, secretion of proinflammatory cytokines, and pyroptotic cell death. Several recent studies have addressed the role of the NLRP3 inflammasome in T. gondii infection without reaching a consensus on its roles. Moreover, the mechanisms of NLRP3 inflammasome activation in different cell types remain unknown. Here we review current research on the activation and specific role of the NLRP3 inflammasome in T. gondii infection.

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Section: The Function Of Other Nlr Families In T Gondii ...mentioning

confidence: 99%

The strategies of NLRP3 inflammasome to combat Toxoplasma gondii

Yoon¹,

Ham²,

Gil³

et al. 2022

Front. Immunol.

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show abstract

“…The active caspase-1 then cleaves pro-inflammatory cytokines pro-IL - 1β and pro-IL - 18. The NLRP 1, NLRP 3, and NLRP12 inflammasome are important for the control of T. gondii in mice [ 188 , 189 , 190 ] and rat macrophages, respectively [ 189 ]. The NLRP 1 and NLRP 3 are significant for the in vivo control of T. gondii proliferation.…”

Section: Inflammation-associated Factors In Toxoplasmosismentioning

confidence: 99%

Overview of Apoptosis, Autophagy, and Inflammatory Processes in Toxoplasma gondii Infected Cells

et al. 2023

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Toxoplasma gondii (T. gondii) is an obligate intracellular parasite. During the parasitic invasion, T. gondii creates a parasitophorous vacuole, which enables the modulation of cell functions, allowing its replication and host infection. It has effective strategies to escape the immune response and reach privileged immune sites and remain inactive in a controlled environment in tissue cysts. This current review presents the factors that affect host cells and the parasite, as well as changes in the immune system during host cell infection. The secretory organelles of T. gondii (dense granules, micronemes, and rhoptries) are responsible for these processes. They are involved with proteins secreted by micronemes and rhoptries (MIC, AMA, and RONs) that mediate the recognition and entry into host cells. Effector proteins (ROP and GRA) that modify the STAT signal or GTPases in immune cells determine their toxicity. Interference byhost autonomous cells during parasitic infection, gene expression, and production of microbicidal molecules such as reactive oxygen species (ROS) and nitric oxide (NO), result in the regulation of cell death. The high level of complexity in host cell mechanisms prevents cell death in its various pathways. Many of these abilities play an important role in escaping host immune responses, particularly by manipulating the expression of genes involved in apoptosis, necrosis, autophagy, and inflammation. Here we present recent works that define the mechanisms by which T. gondii interacts with these processes in infected host cells.

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NLRP3 inflammasome is involved in the mechanism of the mitigative effect of lycopene on sulfamethoxazole-induced inflammatory damage in grass carp kidneys

Liu

et al. 2022

Fish & Shellfish Immunology

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Toxoplasma gondii activates NLRP12 inflammasome pathway in the BALB/c murine model

Cited by 7 publications

References 32 publications

The strategies of NLRP3 inflammasome to combat Toxoplasma gondii

The strategies of NLRP3 inflammasome to combat Toxoplasma gondii

Overview of Apoptosis, Autophagy, and Inflammatory Processes in Toxoplasma gondii Infected Cells

NLRP3 inflammasome is involved in the mechanism of the mitigative effect of lycopene on sulfamethoxazole-induced inflammatory damage in grass carp kidneys

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