Toxopathological and cytogenetic effects of aflatoxin B1 (AFB1) on pregnant rats

Fetaih, Hamdy; Dessouki, Amina; Hassanin, Abeer A. I.; Tahan, Ahmed S.

doi:10.1016/j.prp.2014.06.001

Cited by 41 publications

(42 citation statements)

References 33 publications

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“…The highest tested AFB 1 dose (663 μg/kg of b.w.) was based on the chronic AFB 1 dose used in other studies [ 13 , 33 ] and represents approximately 1% of the LD 50 for mice. The duration of exposure was based on the plasma half-life of AFB 1 in male rats, which is approximately 92 h [ 34 ].…”

Section: Methodsmentioning

confidence: 99%

Impact of a Single Oral Acute Dose of Aflatoxin B1 on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice

Ishikawa

Hirooka

Silva

et al. 2017

Toxins

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Aflatoxin B1 (AFB1), a mycotoxin found in food and feed, exerts harmful effects on humans and animals. The liver is the earliest target of AFB1, and its effects have been evaluated in animal models exposed to acute or chronic doses. Considering the possibility of sporadic ingestion of AFB1-contaminated food, this study investigated the impact of a single oral dose of AFB1 on liver function/cytokines and the lymphoproliferative response in mice. C57BL/6 mice were treated with a single oral AFB1 dose (44, 442 or 663 μg AFB1/kg of body weight) on the first day. Liver function (ALT, γ-GT, and total protein), cytokines (IL-4, IFN-γ, and IL-17), histopathology, and the spleen lymphoproliferative response to mitogens were evaluated on the 5th day. Although AFB1 did not produce any significant changes in the biochemical parameters, 663 μg AFB1/kg-induced hepatic upregulation of IL-4 and IFN-γ, along with liver tissue injury and suppression of the lymphoproliferative response to ConA (p < 0.05). In conclusion, a single oral dose of AFB1 exposure can induce liver tissue lesions, liver cytokine modulation, and immune suppression in C57BL/6 mice.

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Section: Methodsmentioning

confidence: 99%

Impact of a Single Oral Acute Dose of Aflatoxin B1 on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice

Ishikawa

Hirooka

Silva

et al. 2017

Toxins

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show abstract

“…In addition, the chronic form of aflatoxicosis includes teratogenic effects in animals, which are associated with congenital malformations and, in the fetuses, multiple skeletal anomalies as incomplete ossification of skull bones and failure of ossification of long and flat bones, as well as delay in the intramembranous ossification process, defects in the vertebrae formation or their reduction in size. Other mutagenic effects of aflatoxins cover mutations in genes, alterations of DNA by chromosomal breaks, rearrangement of chromosome pieces or even acquisition or loss of entire chromosomes (Fetaih et al, 2014).…”

Section: Hepatotoxic Carcinogenic and Mutagenic Effectsmentioning

confidence: 99%

Adverse Effects, Transformation and Channeling of Aflatoxins Into Food Raw Materials in Livestock

et al. 2019

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“…Aflatoxin AFB 1 is a powerful carcinogen for human and many animal species, including rodents (Fetaiha et al, 2014), non-human primates and fish (Kimura et al, 2004;Santacroce et al, 2008). It can increase the rate of DNA adducts, histidine revertants, chromosomal aberration, mi-…”

Section: Resultsmentioning

confidence: 99%

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

Mishra¹,

Tandon²,

Dhama³

et al. 2016

Adv. Anim. Vet. Sci.

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| We have investigated the protective effect of oral administration of the ethanolic extract of Bougainvillea spectabilis leaves against aflatoxin B 1 (AFB 1 ) induced hepatic injuries among male Swiss albino mice. AFB 1 exposure has significantly increased (P< 0.05) the lipid peroxidase activity and decreased the activities of various antioxidant enzymes viz. superoxide dismutase (57.58%), catalase (24.14%), glutathione peroxidase (44.21%), glutathione S-transferase (44.07%) and glutathione reductase (13.51%). It also declined the level of ascorbic acid, reduced glutathione and protein contents by 47%, 34% and 24% respectively. It markedly decreased lipid peroxidation (TBARS level) with concomitant stimulation (P < 0.05) of antioxidants (enzymatic and non -enzymatic both). HPTLC analysis revealed availability of sufficient amount of flavonoids, alkaloids and phenolic compounds in the extract of B. spectabilis leaves might be responsible for the improved efficiency of antioxidant system and subsequent protection from aflatoxicity.

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Toxopathological and cytogenetic effects of aflatoxin B1 (AFB1) on pregnant rats

Cited by 41 publications

References 33 publications

Impact of a Single Oral Acute Dose of Aflatoxin B1 on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice

Impact of a Single Oral Acute Dose of Aflatoxin B1 on Liver Function/Cytokines and the Lymphoproliferative Response in C57Bl/6 Mice

Adverse Effects, Transformation and Channeling of Aflatoxins Into Food Raw Materials in Livestock

Does Bougainvillea spectabilis protect Swiss Albino Mice from Aflatoxin-induced Hepatotoxicity?

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