Toxocara Canis-Induced Airway Hyporeactivity in Mice

Buijs, J.; Egbers, Martin W. E. C.; Nijkamp, Frans P.

doi:10.1007/978-3-0348-7379-6_9

“…Buijs et al 110 sugerem que somente crianças com predisposição atópica demonstram associação entre infecção por T. canis e manifestações alérgicas; assim como Taylor et al 69 não encontraram associação entre asma e ELISA positivo para T. canis. Na literatura, há descrição de presença de broncoespasmo em crianças com toxocaríase 25,31,51,73 .…”

Section: Comprometimento Visceral De Outros Sistemasunclassified

“…Glickman et al 97 observaram que pacientes com presença de IgE elevada e eosinófilos no sangue periférico acima de 400 células/ mm 3 apresentavam 82% de probabilidade de desenvolver toxocaríase. Alguns autores também demonstraram essas associações 23,110,123 , o que sugere a natureza alérgica da infecção por T. canis. Os estudos publicados utilizaram diferentes pontos de corte para eosinofilia, independente da idade do paciente, e encontraram associações entre eosinófilos acima de 400 16 , 1.000 32,58 , 2.000 21 e 3.000 55 células/mm 3, e sorologia positiva para T. canis.…”

Section: Diagnósticounclassified

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Toxocariasis: visceral larva migrans in children

Carvalho¹,

Rocha²

2011

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Objectives: To present a detailed investigation of risk factors, symptoms, and laboratory and imaging tests that may be useful to establish the clinical laboratory diagnosis of visceral larva migrans (VLM) in children, demonstrating the importance of diagnosis and treatment to prevent complications in the eyes, liver, and other organs. Sources:Literature review using the MEDLINE and LILACS (1952-2009) databases, selecting the most recent and representative articles on the topic. Summary of the findings:VLM is an infectious disease with nonspecific clinical presentation, whose transmission is related to contact with dogs, especially puppies, and which may progress to late systemic complications in vital organs such as the eyes and the central nervous system. IgG (ELISA) anti-T. canis can be used to establish the laboratory diagnosis. Higher cutoff points suggest recent illness and lower cutoff points demonstrate mild infection or infection in remission. Therapeutic response may be assessed by means of eosinophil blood cell count. The present article provides the pediatrician with updated information regarding VLM, a disease of high prevalence worldwide and in Brazil. Conclusions:The diagnosis of VLM depends mainly on the presence of dogs in the child's household, associated with ELISA (IgG anti-T. canis), using excretory-secretory antigens of Toxocara canis. Prospective studies are warranted to assess the best drug therapy. Prevention is the most important strategy because of the high prevalence of T. canis in urban areas.J Pediatr (Rio J). 2011;87(2):100-110: Toxocara canis, dogs, infection, epidemiology, ELISA, prevalence. ResumoObjetivos: Apresentar investigação detalhada de fatores de risco, sintomatologia, exames laboratoriais e de imagem que possam contribuir para o diagnóstico clínico-laboratorial da larva migrans visceral (LMV) em crianças e mostrar a importância do diagnóstico e do tratamento para evitar complicações oculares, hepáticas e em outros órgãos. Fontes dos dados:Revisão de literatura utilizando os bancos de dados MEDLINE e LILACS , selecionando os artigos mais atuais e representativos do tema. Síntese dos dados:LMV é uma doença infecciosa de apresentação clínica inespecífica cuja transmissão está relacionada ao contato com cães, principalmente filhotes, podendo evoluir com complicações sistêmicas tardias em órgãos vitais como o olho e sistema nervoso central. Para diagnóstico laboratorial, pode ser utilizado IgG (ELISA) anti-Toxocara canis, cujos pontos de corte mais elevados sugerem doença recente e, os mais baixos, infecção leve ou em resolução. A resposta terapêutica pode ser avaliada por meio da contagem de eosinófilos no sangue. Esse artigo atualiza o pediatra em relação à LMV, doença de alta prevalência no mundo e no Brasil.Conclusões: O diagnóstico de LMV depende principalmente da epidemiologia da presença de cães no domicílio da criança, associada ao ELISA (IgG para T. canis), utilizando antígenos Toxocara de excreção e secreção. São necessários estudos prospectivos para avali...

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“…[106][107][108] The presence of asthma in patients with toxocariasis has been reported by some authors, 95 and the association between asthma and toxocariasis was described in some studies. 16,109 Buijs et al 110 suggested that only children with atopic predisposition shown an association between infection with T. canis and allergic reactions; in agreement with that, Taylor et al 69 found no association between asthma and positive ELISA for T. canis.…”

Section: Asymptomatic Toxocariasismentioning

confidence: 80%

“…Some authors also demonstrated these associations, 23,110,123 which suggests that the allergic nature of the infection with T. canis.…”

Section: Immune Responsementioning

confidence: 90%

Toxocaríase: larva migrans visceral em crianças e adolescentes

Carvalho¹,

Rocha²

2011

J. Pediatr. (Rio J.)

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Objectives: To present a detailed investigation of risk factors, symptoms, and laboratory and imaging tests that may be useful to establish the clinical laboratory diagnosis of visceral larva migrans (VLM) in children, demonstrating the importance of diagnosis and treatment to prevent complications in the eyes, liver, and other organs.Sources: Literature review using the MEDLINE and LILACS (1952-2009) databases, selecting the most recent and representative articles on the topic. Summary of the findings:VLM is an infectious disease with non-specific clinical presentation, whose transmission is related to contact with dogs, especially puppies, and which may progress to late systemic complications in vital organs such as the eyes and the central nervous system. IgG (ELISA) anti-T. canis can be used to establish the laboratory diagnosis. Higher cutoff points suggest recent illness and lower cutoff points demonstrate mild infection or infection in remission. Therapeutic response may be assessed by means of eosinophil blood cell count. The present article provides the pediatrician with updated information regarding VLM, a disease of high prevalence worldwide and in Brazil. Conclusions:The diagnosis of VLM depends mainly on the presence of dogs in the child's household, associated with ELISA (IgG anti-T. canis), using excretory-secretory antigens of Toxocara canis. Prospective studies are warranted to assess the best drug therapy. Prevention is the most important strategy because of the high prevalence of T. canis in urban areas. Adult worms live on average 4 months and, after about 6 months, almost all are spontaneously eliminated by the host. 4

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Prevalência De Toxocaríase E Fatores Associados Em Crianças De Uma Escola Pública Em Belo Horizonte, Minas Gerais, Brasil

Campos

¹

,

Carvalho

²

,

Soares

³

et al. 2017

Infarma

0

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A high prevalence of toxocariasis has been observed in many countries worldwide, especially in tropical countries. The present study aimed to estimate the prevalence of toxocariasis and its associated factors in 100 children from a public school in the city of Belo Horizonte, Brazil. Sociodemographic data, lifestyle habits, self-reported health conditions, as well as characteristics related to housing and the presence of pets, were collected. In addition, clinical exams, anthropometric measurements, and laboratory exams (hemogram, total IgG, total IgE, and anti-Toxocara canis IgG ELISA) were carried out. Among the evaluated children, 15% presented positive serology for toxocariasis. The participants with positive and negative results were compared by means of either a Student's t test, for the two samples, or the Mann-Whitney test, and only the total IgG parameter proved to be statistically different among them. Considering the positive serology, the variable of age, the presence of puppies, contact with the ground, and the BMI (thinness) status proved to be significantly associated. These variables were included in a multiple logistics regression model to identify the factors independently associated with the response variable. The significance level adopted in the final model was of 0.05. Also in the final model, the variable of contact with the ground and the BMI status remained at a p-value of 0.025 and 0.030, respectively. An epidemiologically relevant prevalence of toxocariasis was found in the studied population. This prevalence serves as a warning sign that disease control measures need to be better publicized and implemented.Keywords: children; zoonoses; seroepidemiologic studies; toxocariasis RESUMOTem sido demostrada uma alta prevalência de toxocaríase em diferentes países do mundo, principalmente nos países tropicais. Dessa forma o objetivo desse estudo foi estimar a prevalência de toxocaríase e seus fatores associados em cem crianças de uma escola pública de Belo Horizonte, Brasil. Foram coletadas informações sociodemográficas, hábi-tos de estilo de vida, condições de saúde autorreferida, características relacionadas à moradia e à presença de animais domésticos. Também foram realizados exames clínicos, medidas antropométricas e exames laboratoriais (hemograma, IgG total, IgE total e ELISA para detecção de anticorpos IgG anti-Toxocara canis). Entre as crianças avaliadas,

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Toxocara Canis-Induced Airway Hyporeactivity in Mice

Cited by 4 publications

References 5 publications

Toxocariasis: visceral larva migrans in children

Toxocariasis: visceral larva migrans in children

Toxocaríase: larva migrans visceral em crianças e adolescentes

Prevalência De Toxocaríase E Fatores Associados Em Crianças De Uma Escola Pública Em Belo Horizonte, Minas Gerais, Brasil

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