Toxocara canis and lead alter consummatory behavior in mice

Donovick, Peter J.; Dolinsky, Zelig S.; Perdue, Valerie P.; Burright, Richard G.; Summers, B. A.; Cypess, Raymond H.

doi:10.1016/0361-9230(81)90022-8

Cited by 17 publications

(12 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stretch et al (37) suggested that changes in motivation were critical to some aspects of the behavior displayed by the host following infection with S. mansoni. Furthermore, we reported recently that patterns of sensory reactivity, as reflected in changes in consumption when palatability of the available fluid was altered, changed following infection with T. canis (19). Such observations lend further support to the notion that the pattern of behavioral changes and task specificity observed following infection with T. canis cannot be attributed uniquely to either ability to perform complex motor tasks or general malaise.…”

Section: T Canis: Brain and Behaviorsupporting

confidence: 70%

“…Nelson (3) suggests that there may be cross-protection between infection with various related organisms. We found that exposure to lead also may diminish the behavioral impact of infection (18)(19)(20). That is, infected mice which were exposed either simultaneously (18,19) or previously (20) to lead showed less dramatic changes in behavior than infected animals without such exposure to a toxicant.…”

Section: Immunological Considerationmentioning

confidence: 73%

“…We found that exposure to lead also may diminish the behavioral impact of infection (18)(19)(20). That is, infected mice which were exposed either simultaneously (18,19) or previously (20) to lead showed less dramatic changes in behavior than infected animals without such exposure to a toxicant. Interestingly, the neuropathology observed using light microscopic techniques was confined primarily to large myelinated fiber tracts, but was not different between animals exposed to parasite alone or in combination with lead (5).…”

Section: Immunological Considerationmentioning

confidence: 73%

“…Thus, there are no eggs passed in the feces, and only indirect diagnostic assays such as serological tests are available to suggest the presence of T. canis (8). The dimension of the problem is apparent when one takes into account: (a) a survey cited by Jacobs (9) Further, the host may gain protection through exposure to both other organisms (3) and other toxic substances (18)(19)(20).…”

Section: T Canis: Brain and Behaviormentioning

confidence: 99%

“…canis may alter a broad spectrum of behavior in the mouse, including reactivity to taste (19) and exploration of the environment (18,(28)(29)(30). Altered patterns of learning performance in mice (18) and rats (31) also have been seen following infection with T. canis.…”

Section: T Canis: Brain and Behaviormentioning

confidence: 99%

See 4 more Smart Citations

The Consequences of Parasitic Infection for the Behavior of the Mammalian Host

Donovick¹,

Burright²

1987

Environmental Health Perspectives

Self Cite

View full text Add to dashboard Cite

Section: T Canis: Brain and Behaviorsupporting

confidence: 70%

Section: Immunological Considerationmentioning

confidence: 73%

Section: Immunological Considerationmentioning

confidence: 73%

Section: T Canis: Brain and Behaviormentioning

confidence: 99%

Section: T Canis: Brain and Behaviormentioning

confidence: 99%

See 3 more Smart Citations

The Consequences of Parasitic Infection for the Behavior of the Mammalian Host

Donovick¹,

Burright²

1987

Environmental Health Perspectives

Self Cite

View full text Add to dashboard Cite

Experimental toxocariasis and hyperactivity in mice

et al. 1986

View full text Add to dashboard Cite

An observational study using videorecordings and computer-assisted data analysis was undertaken in order to investigate the behaviour of mice infected with larvae of Toxocara canis. The findings indicated that the infection had a marked effect on five readily and reliably differentiable categories of murine behaviour. A marked increase in the number of shorter bouts of each of the five behaviours was also associated with the infection. These results support previous findings and further suggest that T. canis infection affects the way in which mice respond to their environment. In particular the infection appears to be associated with hyperactivity in mice. Possible causes of such behavioural abnormalities as well as implications of these findings for clinical studies concerned with relationships between T. canis infection and hyperactivity in children are discussed.

show abstract