Toxisch epidermale Nekrolyse

Jäckel, R; Fuchs, Mary Anne; Raff, Thorsten; Wiedemann, B.

doi:10.1007/s00101-002-0404-8

Cited by 6 publications

(1 citation statement)

References 38 publications

(95 reference statements)

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“…Another case report also describes the onset of SJS in a patient with alcohol abuse following treatment of withdrawal symptoms with carbamazepine, although a possible link with alcohol abuse was not suspected. [24] A further three reports of SJS in patients with alcohol abuse have been published for other drugs, that is, lamotrigine, [25] chlarithromycin and/or disulfiram, [26] and phenytoin. [27] One case report also describes recurrent EM in a patient on therapy with ciprofloxacin after ingestion of alcohol.…”

Section: Discussionmentioning

confidence: 99%

Identification of risk factors for carbamazepine-induced serious mucocutaneous adverse reactions: A case-control study using data from spontaneous adverse drug reaction reports

Bertulyte

Schwan²,

Hallberg

2014

Journal of Pharmacology and Pharmacotherapeutics

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Objectives:To identify risk factors other than genetic for severe carbamazepine-induced mucocutaneous reactions, that is, SJS, TEN, and exfoliative dermatitis (ED).Materials and Methods:We did a case-control study using data from the Swedish national database of spontaneously reported adverse drug reactions (ADRs). We selected all patients who had been reported from January 1, 1965 to March 31, 2010 as having experienced SJS (n = 78), TEN (n = 6), or ED (n = 8), and assessed as at least possibly related to carbamazepine. We also included diagnoses possibly representative of early signs of these serious conditions, that is, erythema multiforme (EM, n = 34) and scaly rash (n = 13). We compared data on demographics, drug treatment, and clinical features for these patients (cases, n = 139) with those from patients who had experienced any other type of ADR from carbamazepine during the same time period (controls, n = 887).Results:After adjustment for multiple comparisons, alcohol abuse was statistically significantly more common among cases than controls (34.5% vs 8.7%, odds ratio 5.5 [95% confidence interval 3.6-8.4], P = 3.14 × 10-14 ). The same was seen for SJS and EM individually.Conclusion:Alcohol abuse is a possible risk factor for serious carbamazepine-induced mucocutaneous reactions.

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Section: Discussionmentioning

confidence: 99%

Identification of risk factors for carbamazepine-induced serious mucocutaneous adverse reactions: A case-control study using data from spontaneous adverse drug reaction reports

Bertulyte

Schwan²,

Hallberg

2014

Journal of Pharmacology and Pharmacotherapeutics

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Other Benign Colorectal Disorders

Maykel¹,

Steele

2011

The ASCRS Textbook of Colon and Rectal Surgery

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Behandlung der toxischen epidermalen Nekrolyse

et al. 2006

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Toxic epidermal necrolysis (TEN) is the maximal variant of severe bullous drug reactions with a high mortality rate of 30-40%. Treatment should be interdisciplinary and is best provided in an intensive care setting. Since no specific therapy has been established, supportive intensive care and topical treatment are of crucial importance. Between 1995 and 2005, nine patients with TEN were treated in the anesthesiology intensive care unit in cooperation with dermatology in the University Hospital of Dresden. All patients initially received corticosteroids and five patients were additionally treated with intravenous immunoglobulins (IVIG). The overall mortality of 33% was underestimated by the SAPS II-Score, whereas it was overestimated by the TEN-specific SCORTEN. In more severely affected patients, other scoring systems in addition to SCORTEN should be used for prediction of prognosis and evaluation of therapy. The mortality rate of our IVIG treated patients was 20% vs. 50% compared to the non-IVIG-group. However, due to the small number of patients and contradictory results in the literature, IVIG cannot be generally recommended for the treatment of TEN, but should be considered in early stages of the disease.

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Toxisch epidermale Nekrolyse

Cited by 6 publications

References 38 publications

Identification of risk factors for carbamazepine-induced serious mucocutaneous adverse reactions: A case-control study using data from spontaneous adverse drug reaction reports

Identification of risk factors for carbamazepine-induced serious mucocutaneous adverse reactions: A case-control study using data from spontaneous adverse drug reaction reports

Other Benign Colorectal Disorders

Behandlung der toxischen epidermalen Nekrolyse

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