Toxins and derivatives in molecular pharmaceutics: Drug delivery and targeted therapy

Zhan, Changyou; Li, Chong; Wei, Xiaoli; Lu, Wuyuan; Lu, Weiyue

doi:10.1016/j.addr.2015.04.025

Cited by 46 publications

(16 citation statements)

References 210 publications

(39 reference statements)

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“…However, the enzymatically protective barriers in brain capillary endothelial cells, rigorously threaten the stability of these peptide-based ligands, thus attenuating their efficacies to complete the unidirectional transport and targeting ability. Previously, a stable 16 residue peptide, G D R D E D I D R D TG D R D A D E D R D W D S D E D K D F ( D CDX) consisting of D-amino acids was reported to be fully resistant to proteolytic degradation and effectively overcome enzymatic barrier [13,14]. It was proved that this peptide exhibited high binding affinity to nAChRs highly expressed on BBB and efficiently inspired brain-targeted delivery of the encapsulated payloads.…”

Section: Introductionmentioning

confidence: 99%

Liposome-based glioma targeted drug delivery enabled by stable peptide ligands

Wei

Gao

Zhan

et al. 2015

Journal of Controlled Release

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119

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Section: Introductionmentioning

confidence: 99%

Liposome-based glioma targeted drug delivery enabled by stable peptide ligands

Wei

Gao

Zhan

et al. 2015

Journal of Controlled Release

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119

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“…Among different classes of targeting ligands, peptides are the objective of increasing scrutiny due, at least partially to their ease of synthesis and high throughput screening 8 , 9 . Peptide ligands exhibit high potency and specificity by occupying large interface of corresponding receptors 10 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Enhanced immunocompatibility of ligand-targeted liposomes by attenuating natural IgM absorption

et al. 2018

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Targeting ligands are anticipated to facilitate the precise delivery of therapeutic agents to diseased tissues; however, they may also severely affect the interaction of nanocarriers with plasma proteins. Here, we study the immunocompatibility of brain-targeted liposomes, which inversely correlates with absorbed natural IgM. Modification of long, stable positively charged peptide ligands on liposomes is inclined to absorb natural IgM, leading to rapid clearance and enhanced immunogenicity. Small peptidomimetic D8 developed by computer-aided peptide design exhibits improved immunocompatibility by attenuating natural IgM absorption. The present study highlights the effects of peptide ligands on the formed protein corona and in vivo fate of liposomes. Stable positively charged peptide ligands play double-edged roles in targeted delivery, preserving in vivo bioactivities for binding receptors and long-term unfavorable interactions with the innate immune system. The development of D8 provides insights into how to rationally design immunocompatible drug delivery systems by modulating the protein corona composition.

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“…For facilitated entry of these proteins into the intestine, GM1 and globotriaosylceramide receptors on the intestinal epithelial cells have been used by several pathogens such as Vibrio cholerae and Shigella dysenteriae [14,15]. protein such as CTB is needed [2].…”

Section: Discussionmentioning

confidence: 99%