Toxikologische Bewertung von Rüstungsaltlasten

Schneider, Klaus; Hassauer, Martin; Kalberlah, Fritz

doi:10.1007/bf02937716

Cited by 9 publications

(2 citation statements)

References 25 publications

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“…Aufgrund dieses Ergebnisses ist es fraglich, ob die auf theoretischen Über-legungen beruhenden Expositionsabschätzungen [31,32,33] die Expositionssituation der Bewohner des kontaminierten Geländes realistisch widerspiegeln. Die Ergebnisse des Biomonitorings mit Hämoglobinaddukten sprengstofftypischer Nitroaromaten geben jedenfalls keinen Hinweis darauf, dass die Bewohner des kontaminierten Geländes ein höheres Krebsrisiko tragen als die Vergleichspersonen.…”

Section: Aromatische Amine Und Nitroaromaten Als Umweltschadstoffeunclassified

Verwendung von H�moglobinaddukten als Biomarker f�r das Monitoring von Belastungen und Beanspruchungen durch gentoxische Stoffe

2003

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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Section: Aromatische Amine Und Nitroaromaten Als Umweltschadstoffeunclassified

Verwendung von H�moglobinaddukten als Biomarker f�r das Monitoring von Belastungen und Beanspruchungen durch gentoxische Stoffe

2003

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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“…Risk assessment of contaminated sites and remediated soil is a complicated and controversial task ( , ). One major problem is the lack of data concerning the impact of these xenobiotics on humans since most available toxicological data deal with effects on animals, plants, and microorganisms, and it remains questionable whether results of these tests can be extrapolated to probable effects in human beings.…”

Section: Introductionmentioning

confidence: 99%

Effect of 2,4,6-Trinitrotoluene and Its Metabolites on Human Monocytes

Bruns-Nagel

Scheffer

Casper

et al. 1999

Environ. Sci. Technol.

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A lucigenin-dependent chemiluminescence (CL) assay was developed in which primary human monocytes were used as test cells. 2,4,6-Trinitrotoluene (TNT) and a number of its metabolites were subjected to this test system. A dose-dependent inhibition of CL was observed for most compounds. The following EC50 values were determined: TNT = 8 μg/mL; 2,4-DANT = 5 μg/mL; 4-ADNT = 38 μg/mL; 2-ADNT = >50 μg/mL; 4-acetyl-2,6-DNT= 50 μg/mL, and 2-acetyl-4,6-DNT = >50 μg/mL. The CL assay was also applied to aqueous extracts of TNT-contaminated soil before and after bioremediation and to soil extracts free of any nitroaromatics. Extracts of non-contaminated soil reduced the CL by about 60%, whereas an extract of contaminated soil was 100% suppressive. Leachates of bioremediated soil caused a similar response as compost free of any nitroaromatics. The results demonstrate the usefulness of a primary human monocyte culture system for testing environmentally toxic compounds.

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