Toxikologische Beeinflussung peripherer und zentraler akustischer Reizantworten durch Gentamycinsulfat

Stange, G.

doi:10.1007/bf02487057

Arch. Klin. Exp. Ohr.-, Nas.- U. Kehlk. Heilk.

1970

DOI: 10.1007/bf02487057

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Toxikologische Beeinflussung peripherer und zentraler akustischer Reizantworten durch Gentamycinsulfat

G. Stange¹

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1971

1976

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Cited by 3 publications

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“…The decrease o f the cochlear microphonics and of the slow evoked potentials, and the increase of the compound action potentials in dependence on the gentamycin doses is evident. See text [Stange, 1970], this remedy any more. There are, on the other hand, complamin, xantinol-nicotinat and dextran which have a favourable effect on the auditive artery.…”

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confidence: 99%

Comparative Research on the Acoustic System

Beck¹,

Stange²

1971

ORL

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We know a great number of methods for investigating the Physiology and Pathophysiology of the acoustic system, but seldom were several methods applied together to solve one single problem. In our own experiments we demonstrate the importance of correlated investigations on the acoustic system. They show, e.g., that functional impairment of the sensory cells in the organ of corti, caused by ototoxic drugs, can earlier be seen than morphological changes. The sensory cells with nuclear swelling are functionally inactive, and even those with morphologically normal appearance sometimes show functional impairment. A differentiation of damages caused either by acoustic stimulation or by ototoxic drugs is possible by electrophysiological and immunophoretical but not by morphological means. Therefore we think that the correlation between morphological, electrophysiological and biochemical findings gives us better information about the inner ear function.

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confidence: 99%

Comparative Research on the Acoustic System

Beck¹,

Stange²

1971

ORL

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Beeinflussung des akustischen Traumas durch einen Ginkgo-biloba-Extrakt

Stange

Benning

1975

Arch Otorhinolaryngol

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A fraction of Ginkgo biloba, used in experiments with animals ensured significantly the diminution of sound damages caused by white noise or by a pure tone of 4.5 kHz. Higher amplitudes of the acoustic nerve potentials show the protective effect of this fraction of Ginkgo biloba at acute sound damages. It is moreover possible to hold physiologically the adaptation of excitation of the hair cells of the organ of Corti by the fraction of Ginkgo biloba before and after sound damage caused by white noise or during a pure tone of 4.5 kHz. The influence of the fraction of Ginkgo biloba can be seen by a significantly slower recovery of the noise damaged evoked potentials of the acoustic cortex. An efferent protective influence on the neurons of the acoustic cortex is discussed. The fraction of Ginkgo biloba in this form of solution has not been tested for clinical use but it seems to be rich in meaning.

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Ototoxicity of the aminoglycoside antibiotics

Federspil

1976

Infection

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A report is given on advances in our knowledge of the ototoxicity of aminoglycoside antibiotics. The pharmacokinetics of gentamicin, tobramycin, sisomicin and amikacin in the inner ear, cerebrospinal fluid, compartments of the eye and serum were determined by means of pharmacokinetical investigations. The influence of long-term treatment, and the effects of otitis media and uremia were also studied. Furthermore, the influence of therapeutic methods on ototoxic damage was investigated, and the ototoxicity of these antibiotics was compared. The experiments were performed in guinea pigs, concentrations of the antibiotics being measured by a microbiological method and confirmed by investigations with C14 labeled gentamicin. The hair cell degeneration pattern after administration of the new aminoglycosides was determined using surface preparations. The prophylactic effect upon ototoxicity of the administration of dimercaptopropanol or of dividing up the daily dosage was examined. Studies were made of ototoxicity in children, and in patients with otitis media or renal impairment, and the effect of simultaneous ethacrynic acid or noise was assessed. The problem of delayed and progressive ototoxicity, and the reversibility of ototoxic damage caused by these antibiotics was examined histologically, and the ototoxicity of gentamacin, tobramycin, sisomicin and amikacin was compared. The influence of the new aminoglycoside antibiotics upon the amount of acidic and alkaline phosphatase and unspecific esterases in the inner ear was studied. The clinical importance of the latest experimental findings is emphasised. The clinical picture of ototoxic damage after administration of the new aminoglycoside antibiotics shows no special characteristics. The ototoxicity of these antibiotics after topical use is mentioned. Attention is drawn to guidelines for the prevention of ototoxic damage by aminoglycosides.

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Toxikologische Beeinflussung peripherer und zentraler akustischer Reizantworten durch Gentamycinsulfat

Cited by 3 publications

References 7 publications

Comparative Research on the Acoustic System

Comparative Research on the Acoustic System

Beeinflussung des akustischen Traumas durch einen Ginkgo-biloba-Extrakt

Ototoxicity of the aminoglycoside antibiotics

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