Toxicology:
            <i>Quantitative Toxicology</i>
            . Selected Topics. V. A. Filov, A. A. Golubev, E. I. Liublina, and N. A. Tolokontsev. Translated from the Russian edition (1973) by V. E. Tatarchenko. Wiley-Interscience, New York, 1980. xviii, 462 pp., illus. $32.50. Environmental Science and Technology.

Vouk, Velimir B.

doi:10.1126/science.210.4468.418

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“…Several databases have been established to better a College of Information Engineering, Shanghai Maritime University, Shanghai 201306, People's Republic of China. E-mail: chen_lei1@163.com; Fax: +86-21-38282800; Tel: +86-21-38282826 b Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological record and classify these potential carcinogens, and these include the IARC (International Agency for Research on Cancer, http://www.iarc.fr) database 17,18 and CPDB (Carcinogenic Potency Database). 19 The IARC classifies agents into five categories based on their carcinogenic likelihoods, whereas the CPDB provides carcinogenic potential data for chemicals based on animal cancer tests.…”

Section: Introductionmentioning

confidence: 99%

A computational method for the identification of new candidate carcinogenic and non-carcinogenic chemicals

et al. 2015

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Cancer is one of the leading causes of human death. Based on current knowledge, one of the causes of cancer is exposure to toxic chemical compounds, including radioactive compounds, dioxin, and arsenic. The identification of new carcinogenic chemicals may warn us of potential danger and help to identify new ways to prevent cancer. In this study, a computational method was proposed to identify potential carcinogenic chemicals, as well as non-carcinogenic chemicals. According to the current validated carcinogenic and non-carcinogenic chemicals from the CPDB (Carcinogenic Potency Database), the candidate chemicals were searched in a weighted chemical network constructed according to chemical-chemical interactions. Then, the obtained candidate chemicals were further selected by a randomization test and information on chemical interactions and structures. The analyses identified several candidate carcinogenic chemicals, while those candidates identified as non-carcinogenic were supported by a literature search. In addition, several candidate carcinogenic/non-carcinogenic chemicals exhibit structural dissimilarity with validated carcinogenic/non-carcinogenic chemicals.

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Section: Introductionmentioning

confidence: 99%