Toxicology and carcinogenesis studies of dietary titanium dioxide‐coated mica in male and female Fischer 344 rats

Bernard, Bruce K.; Osheroff, Merrill R.; Hofmann, Andreas; Mennear, John H.

doi:10.1080/15287399009531402

Cited by 114 publications

(50 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Micro-sized titanium dioxide is suggested to be biologically inert (11,12), although an inflammatory response has been described (10). Particles can generate reactive oxygen species; particularly in the case of nano-sized particles, DNA adducts are observed in human lung cells (9,13).…”

Section: Induction Of Altered Mrna Expression Profiles Caused By Fibrmentioning

confidence: 99%

Induction of altered mRNA expression profiles caused by fibrous and granular dust

Helmig

Dopp

Wenzel

et al. 2013

Molecular Medicine Reports

View full text Add to dashboard Cite

Section: Induction Of Altered Mrna Expression Profiles Caused By Fibrmentioning

confidence: 99%

Induction of altered mRNA expression profiles caused by fibrous and granular dust

Helmig

Dopp

Wenzel

et al. 2013

Molecular Medicine Reports

View full text Add to dashboard Cite

“…The photocatalytic effect of TiO 2 has been applied to cancer treatment [20][21][22][23][24][25], and US irradiation is an alternative energy source for TiO 2 [26][27][28]. Furthermore, toxicological examinations have shown that the TiO 2 nanoparticle is basically nontoxic for experimental cells or animals [29][30][31]. Therefore, we supposed that sonocatalytic TiO 2 could become a new material in SDT for various cancers involving malignant glioma.…”

Section: Introductionmentioning

confidence: 99%

Sonodynamic therapy using water-dispersed TiO2-polyethylene glycol compound on glioma cells: Comparison of cytotoxic mechanism with photodynamic therapy

Yamaguchi

Kobayashi

Narita

et al. 2011

Ultrasonics Sonochemistry

138

View full text Add to dashboard Cite

Sonodynamic therapy is expected to be a novel therapeutic strategy for malignant gliomas. The titanium dioxide (TiO 2 ) nanoparticle, a photosensitizer, can be activated by ultrasound. In this study, by using water-dispersed TiO 2 nanoparticles, an in vitro comparison was made between the photodynamic and sonodynamic damages on U251human glioblastoma cell lines. Water-dispersed TiO 2 nanoparticles were constructed by the adsorption of chemically modified polyethylene glycole (PEG) on the TiO 2 surface (TiO 2 /PEG). To evaluate cytotoxicity, U251 monolayer cells were incubated in culture medium including 100 μg/ml of TiO 2 /PEG for three hours and subsequently irradiated by

show abstract

“…Titanium dioxide (TiO 2 ) has been increasingly employed in a variety of industrial applications including production of paper, plastics, cosmetics, and paints (Wang et al 2007) and TiO 2 micro-and nanoparticles were classifi ed as comparatively inert (Chen and Fayerweather 1988;Bernard et al 1990;Hart and Hesterberg 1998). These ubiquitous applications lead to increasing human exposure to these nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts

Lai

Lai²,

Jandhyam³

et al. 2008

IJN

View full text Add to dashboard Cite

Abstract:The use of titanium dioxide (TiO 2 ) in various industrial applications (eg, production of paper, plastics, cosmetics, and paints) has been expanding thereby increasing the occupational and other environmental exposure of these nanoparticles to humans and other species. However, the health effects of exposure to TiO 2 nanoparticles have not been systematically assessed even though recent studies suggest that such exposure induces infl ammatory responses in lung tissue and cells. Because the effects of such nanoparticles on human neural cells are unknown, we have determined the putative cytotoxic effects of these nanoparticles on human astrocytes-like astrocytoma U87 cells and compared their effects on normal human fi broblasts. We found that TiO 2 micro-and nanoparticles induced cell death on both human cell types in a concentrationrelated manner. We further noted that zinc oxide (ZnO) nanoparticles were the most effective, TiO 2 nanoparticles the second most effective, and magnesium oxide (MgO) nanoparticles the least effective in inducing cell death in U87 cells. The cell death mechanisms underlying the effects of TiO 2 micro-and nanoparticles on U87 cells include apoptosis, necrosis, and possibly apoptosis-like and necrosis-like cell death types. Thus, our fi ndings may have toxicological and other pathophysiological implications on exposure of humans and other mammalian species to metallic oxide nanoparticles.

show abstract

Toxicology and carcinogenesis studies of dietary titanium dioxide‐coated mica in male and female Fischer 344 rats

Cited by 114 publications

References 16 publications

Induction of altered mRNA expression profiles caused by fibrous and granular dust

Induction of altered mRNA expression profiles caused by fibrous and granular dust

Sonodynamic therapy using water-dispersed TiO2-polyethylene glycol compound on glioma cells: Comparison of cytotoxic mechanism with photodynamic therapy

Exposure to titanium dioxide and other metallic oxide nanoparticles induces cytotoxicity on human neural cells and fibroblasts

Contact Info

Product

Resources

About