Toxicological Study of Derris<sup>1</sup>

Ambrose, Anthony M.; Haag, H. B.

doi:10.1021/ie50319a017

Cited by 21 publications

(10 citation statements)

References 2 publications

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“…From these studies it is evident that there is an appreciable species difference in the response to the substances studied, guinea pigs in general being more susceptible. Similar observations were made in the case of derris (1). Such observations emphasize the danger of generalizing as to the physiological activity of a compound upon the basis of experiments involving only a single species of animals.…”

Section: Acute Oral Toxicitysupporting

confidence: 73%

Toxicological Studies of Derris

Ambrose¹,

Haag²

1937

Ind. Eng. Chem.

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Section: Acute Oral Toxicitysupporting

confidence: 73%

Toxicological Studies of Derris

Ambrose¹,

Haag²

1937

Ind. Eng. Chem.

Self Cite

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“…Consequently it is quite obvious that a combination of rotenone and tetraethyl pyrophosphate for the control of insect pests is unfavourable. Rotenone may be a strong inhibitor of cholinergic or adrenergic systems, some evidence in support of which was brought by Ambrose & Haag (1936 and van Hasselt (1910), who found a low susceptibility of the spinal cord of vertebrates and a much higher susceptibility of the automatic nerve system. More experiments on vertebrate animals, with several combinations of drugs, however, will have to be carried out to establish this.…”

Section: Discussionmentioning

confidence: 91%

Physiological Investigations into the Heart Function of Arthropods

Krijgsman

Krijgsman-Berger

1951

Bull. Entomol. Res.

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Perfusion of the isolated heart of Periplaneta americana with caffeine, digitalin, acetylcholine, nicotine and lobeline shows that the pacemaker of this heart is different from the “ myogenic centre ” of the vertebrate heart.The action of strychnine, morphine and apomorphine on this heart preparation affords evidence of the existence of a neurogenic pacemaker.This pacemaker is stimulated by suitable concentrations of acetylcholine, nicotine, lobeline and pilocarpine, while it is inhibited by atropine. Acetylcholine and tetraethyl pyrophosphate show a synergistic action. Atropine and tetraethyl pyrophosphate, like acetylcholine and curare, show an antagonistic action. These results prove that the neurogenic pacemaker possesses cholinergic properties.Adrenaline stimulates the insect heart and ergotamine inhibits it, thus suggesting that the insect heart probably also has adrenergic properties.On the basis of the present work and the results obtained by other investigators, a theory is put forward that the heart mechanism of most arthropods consists of a neurogenic pacemaker with adrenergic properties, controlled by a cholinergic accelerating nerve. This mechanism bears some resemblance to the sympathetic nerve system of vertebrates.Rotenone strongly counteracts the action of acetylcholine, tetraethyl pyrophosphate, nicotine, lobeline, pilocarpine and digitalin on the insect heart. Its point of action, however, remains obscure at the moment.The opposing action of rotenone and tetraethyl pyrophosphate is an indication that a combination of these insecticides for pest control is not to be recommended.

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“…He called it nicoulinefor it got from the Robinianicou specimen which is now called Lonchocarpusnicou. The efficacies of plants belong to the family Fabaceae were introduced in many thesis research studies and published posthumously in 1895 after his death (Ambrose and Haag, 1936). The rotenone compound was named and also isolated by the Japanese chemical engineer Kazuo Nagai.…”

Section: Rotenonementioning

confidence: 99%

A Review on Tubli Plant used as Organic Pesticide: Input toward Sustainable Agriculture

Biñas

2021

Int. j. res. appl. sci. biotechnol.

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The use of a botanical pesticide like tubli plant crude extracts is one of the practical methods for those farmers who are not capable to incur the expensive commercial pesticides. This contributes to the sustainability of agriculture because it has no adverse effects on the environment. This review article introduces the characteristics of tubli plant and assesses its efficacy as an organic pesticide. The most strong and effective pesticidal property of tubli plant is rotenone which controlled various pests. This had been cultivated and used as an organic pesticide all over the world. Some studies revealed that the application of tubli plants enhanced farmers’ productivity of farms and the profitability of their income. Tubli plant is adapted to be one of the inputs toward sustainable agriculture.

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Toxicological Study of Derris¹

Cited by 21 publications

References 2 publications

Toxicological Studies of Derris

Toxicological Studies of Derris

Physiological Investigations into the Heart Function of Arthropods

A Review on Tubli Plant used as Organic Pesticide: Input toward Sustainable Agriculture

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Toxicological Study of Derris1

Cited by 21 publications

References 2 publications

Toxicological Studies of Derris

Toxicological Studies of Derris

Physiological Investigations into the Heart Function of Arthropods

A Review on Tubli Plant used as Organic Pesticide: Input toward Sustainable Agriculture

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Product

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Toxicological Study of Derris¹