Toxicological studies of the aqueous extract from Achyrocline satureioides (Lam.) DC (Marcela)

Rivera, Felicia; Gervaz, E; Seré, Cecilia; Dajas, Federico

doi:10.1016/j.jep.2004.08.013

Cited by 33 publications

(24 citation statements)

References 12 publications

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“…Apesar de alguns estudos já realizados, os efeitos tóxicos dos extratos de A. satureioides são pouco conhecidos (Rivera et al, 2004). Estudos fi toquímicos têm demonstrado que os fl avonóides quercetina, 3-Ometilquercetina e luteolina são os constituintes mais signifi cativos extraídos por etanol das infl orescências (Ferraro et al, 1981;Simões et al, 1984), além de ácidos caféicos, clorogênicos, isoclorogênicos e glicolipídios terem sido reportados nas partes aéreas (Broussalis et al, 1989;Mendes et al, 2006).…”

Section: Introductionunclassified

Efeito anti-proliferativo das infusões de Achyrocline satureioides DC (Asteraceae) sobre o ciclo celular de Allium cepa

Fachinetto¹,

Bagatini²,

Durigon³

et al. 2007

Rev. bras. farmacogn.

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RESUMO:Achyrocline satureioides (marcela) é utilizada na medicina popular brasileira, na forma de chá, como tratamento de patologias digestivas e infl amatórias. O efeito anti-proliferativo de infusões de marcela sobre o ciclo celular da cebola foi avaliado, utilizando-se infl orescências de marcela recém coletadas (2005) e após armazenamento por 30 meses (2003). Preparou-se as infusões em duas concentrações: 5,0 mg/mL (concentração usual como chá) e 20 mg/mL. Utilizaram-se 3 grupos de 6 bulbos de cebola para cada população de marcela. Retirou-se um grupo de bulbos controle de cada população. Todos os bulbos enraizados em água destilada foram transferidos para os extratos de marcela e permaneceram por 24 horas, (os bulbos controle permaneceram em água). As radículas foram coletadas, fi xadas em etanol-ácido acético (3:1) por 24 h e estocadas em álcool 70%. Foram analisadas 6000 células por grupo de bulbos, e os índices mitóticos calculados submetidos a análise estatística pelo teste 2 a 5%. Conclui-se que as infusões de marcela possuem ação antiproliferativa sobre o ciclo celular da cebola e que essa ação inibitória da divisão celular aumenta conforme aumento da concentração, bem como após o armazenamento.Unitermos: Achyrocline satureioides, Allium cepa, Asteraceae, Liliaceae, atividade antiproliferativa, índice mitótico, planta medicinal.ABSTRACT: "Anti-proliferative effect of infusions of Achyrocline satureioides on the Allium cepa cell cycle". Achyrocline saturoides (marcela) is used in Brazilian folk medicine as a tea in the treatment of digestive and infl ammatory diseases. The anti-proliferative effect of infusions of marcela on onion cell cycle was evaluated by using the infl orescences of recently collected marcela and after the storage for 30 months. Marcela infl orescences were collected for the infusion preparations in 2003 and in 2005 (used still fresh). We prepared the infusions at two concentrations 5.0 mg/mL (concentration used as tea) and 20 mg/mL. We used two groups of six onion bulbs for each population of marcela, and one group of bulbs of each population was withdrawn as a control group. All bulbs rooted in distilled water and after they were transferred to the extracts of marcela and they were kept there for 24 hours (control bulbs remained under water). The root tips were collected, after fi xed in ethanol acetic acid (3:1) for 24 hours and, stored under alcohol 70%. A total of 6000 cells per group of bulbs was analyzed, and the mitotic indexes were calculated and undergone to statistical analysis by using 2 at 5%. The conclusions were that the infusions of marcela have anti-proliferative action on the cell cycle of onion and that this inhibitory action on the cell division increases according to the increase of the infusion concentration, after storage as well.

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Section: Introductionunclassified

Efeito anti-proliferativo das infusões de Achyrocline satureioides DC (Asteraceae) sobre o ciclo celular de Allium cepa

Fachinetto¹,

Bagatini²,

Durigon³

et al. 2007

Rev. bras. farmacogn.

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“…The Achyrocline satureioides species (marcela) shows antioxidant activity, anti-herpes, analgesic, anti-inflammatory, antiviral, etc. (Rivera et al, 2004); has no cytotoxic or genotoxic effects (Sabini et al, 2013). As for Matricaria recutita (chamomile), there are a number of proven biological activities: antimicrobial, antioxidant, antimalarial, and anti-inflammatory, slightly sedative, gastrointestinal and liver benefits, among others (Petronilho et al, 2012.).…”

Section: Moldenkementioning

confidence: 99%

Ethnobotanical Study in Toledo-Pr District: An Approach About Used Species Variability With the Same Popular Name

Holzbach

Olguin

2016

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RESUMO:O conhecimento etnofarmacológico adquirido ao longo da evolução humana culminou com o desenvolvimento de fármacos de grande relevância terapêutica. No levantamento etnobotânico realizado no município de Toledo, em 2007, constatou-se que 79% da população utiliza com frequência plantas para fins medicinais, em sua maioria na forma de chás, oriundas de cultivos próprios e afirmam ter melhora após o consumo das plantas. As plantas mais citadas foram: cidreira, marcela e camomila. Este estudo teve como objetivo verificar se os hábitos da população relacionados com plantas medicinais mudaram, realizar uma revisão na literatura para descobrir se as plantas mais utilizadas têm sua atividade biológica cientificamente comprovada, além de procurar relatos de homônimos para as plantas medicinais mais citadas. Houve uma pequena mudança nas espécies utilizadas pela população. No levantamento bibliográfico, constatou-se que diferentes espécies são utilizadas com a mesma denominação popular, na prática, verificou-se o uso de duas espécies distintas, Piper amalago L. (UNOP 7972) e Piper mikanianum (Kunth) (UNOP 7971), referentes à planta medicinal popularmente conhecida como pariparoba, onde nenhuma equivale à espécie reconhecida pela Farmacopeia Brasileira. Palavras-chave: Cidreira, camomila, marcela, pariparoba, estudo etnobotânico ABSTRACT:The ethnopharmacological knowledge acquired throughout human evolution culminated in the development of high therapeutic relevance drugs. In ethnobotanical survey conducted in the city of Toledo in 2007, it was found that 79% of the population often use plants for medicinal purposes, mostly in the tea form, originated from own crops. They claimed that the consumption of these plants improved their health conditions. The plants mainly cited were: balm, chamomile and marcela. This study aimed to verify if the population habits related to medicinal plants have changed, also proceed a literature review to find out if the most used plants have their biological activity scientifically proven and looking for reports of homonymous to the most cited medicinal plants. There was small change in the species used by the population. In the literature, it was found out that different species are used with the same popular name, in practice, it was detected the use of two different species, Piper amalago L. (UNOP 7972) and Piper mikanianum (Kunth) (UNOP 7971), for the medicinal plant commonly known as pariparoba, although none of them is recognized for the Brazilian Pharmacopoeia.

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“…The extract was administered orally at a dose of 2000 mg kgG 1 b.wt. to different groups of mice and observed for 14 days for signs of behavioral, neurological toxicity and mortality (Rivera et al, 2004).…”

Section: Preliminary Phytochemical Screeningmentioning

confidence: 99%

Antidepressant Activity of Alcoholic Extract of the Fruits of Osmanthus fragrans Lour in Mice

Jawaid¹,

Gupta²,

Rahman³

et al. 2015

Research J. of Medicinal Plant

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Majority of the antidepressant drugs improve depressive symptoms, but they exert multiple unwanted side effects. The search for more efficacious and well tolerated drugs is in progress. Owning to this, the present study was designed to evaluate the antidepressant activity of alcoholic extract of the fruits of Osmanthus fragrans (AEFOF) in mice. It was evaluated using the Tail Suspension Test (TST), Forced Swimming Test (FST) and influence on spontaneous locomotor activity (SLMA) in mice. The AEFOF (75 mg kgG From the present study, it can be concluded that the AEFOF possess potent antidepressant activity as shown by the TST and FST tests and is toxicologically safe.

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Toxicological studies of the aqueous extract from Achyrocline satureioides (Lam.) DC (Marcela)

Cited by 33 publications

References 12 publications

Efeito anti-proliferativo das infusões de Achyrocline satureioides DC (Asteraceae) sobre o ciclo celular de Allium cepa

Efeito anti-proliferativo das infusões de Achyrocline satureioides DC (Asteraceae) sobre o ciclo celular de Allium cepa

Ethnobotanical Study in Toledo-Pr District: An Approach About Used Species Variability With the Same Popular Name

Antidepressant Activity of Alcoholic Extract of the Fruits of Osmanthus fragrans Lour in Mice

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