Toxicological studies and antimicrobial properties of some Iron(III) complexes of Ciprofloxacin

Abstract

Two iron(III) complexes of Ciprofloxacin were synthesized by reaction of the ligand with iron(III) chloride hexahydrate in different solutions. The nature of bonding of the ligands and the structure of the isolated metal complexes were elucidated on the basis of their physical and spectroscopic studies. The infrared spectra suggest that two classes of compounds were obtained: molecular complex in which the ligands were bidentately bonded to the metal through the ring carbonyl oxygen and one of the oxygen of the carboxylate group and the ionic complex consisting of a tetrachlorometalate ion which is electrostatically attached to the ligand. The antibacterial activities of the products against various microorganisms were tested and it was established that their activities were comparable with those of their parent drug. Toxicological studies were carried out in which therapeutic doses of the Ciprofloxacin drug and the metal complexes were administered to albino rats and the results showed that the metal complexes are not toxic.

VITAMINS C AND E AS AMELIORATIVE AGENTS ON BODY TEMPERATURE AND SERUM CHEMISTRY OF WISTAR RATS INFECTED WITH T. brucei brucei (Federe strain)

“…This agrees with the findings of (Hudson (1944); Kalu et al (1988); Adah et al (1992); Ismaila et al (2000); Umar et al (2008), which reported increase in serum liver enzymes level in experimental trypanosomiasis. Increases in the level of these enzymes are indications of damage to liver, brain, and cardiac muscles as documented by Kaplan et al (1988); Malomo (2000); Yakubu et al (2006); Obaleye et al (2007); Wurochekke et al (2008). Similarly, several workers have reported hepatocellular damage and generalized degenerative changes in other tissues and organs in trypanosomiasis (Anosa and Kaneko, 1984a,b,;Bruijn et al, 1987;Pentreath and Kennedy, 2004).…”

Eucommia ulmoides Flavones as Potential Alternatives to Antibiotic Growth Promoters in a Low-Protein Diet Improve Growth Performance and Intestinal Health in Weaning Piglets

“…Similar increases in body weight, average daily gain and feed efficacy between the piglets of antibiotic positive control and EUF treatment were obtained in our present study. In addition, serum TP level and ALP activity could reflect the body protein metabolic stasis [26] and the alteration of soft tissue membrane permeability [27,28], respectively. Although these parameters' values were in physiological ranges, EUF supplementation promoted serum TP content and ALP activity compared to antibiotic positive control, which in a certain extent showing the increased nutrient efficiency and development of piglets and their organs [29].…”

Mn(II), Fe(III) and Ni (II) Complexes of Mixed Citric acid - Sulphamethoxazole: Synthesis, Characterization and Antibacterial activity

“…The spread of infectious diseases is not just associated with poverty but also serve as major hindrance to economic development (Leonard, 1986;Ajibade, 2008). The current challenge faced by synthetic inorganic chemists is how to combat the resistance posed by pathogens to all classes of antimalarial drugs (Peter and Zijian, 1998;Obaleye et al, 2007;Rajee et al, 2018;Chu et al, 1996). Malaria is a major threat to health especially in Africa (Kannan et al, 2005).…”