Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder

Noh, Jung-Ho; Jeong, Ji-Seong; Park, Sang-Jin; Yun, Eun‐Young; Hwang, Jae Sam; Kim, Jiyoung; Jung, Kwang Yoon; Park, Hyojin; Son, Hwa–Young; Moon, Kyoung-Sik

doi:10.1016/j.toxrep.2018.06.001

Cited by 21 publications

(10 citation statements)

References 17 publications

(18 reference statements)

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“…Noh et al. () also reported no toxicological observations with Orotaetia brevitarsis powder (5 g/kg body weight) from the growth curve and gross pathological findings in female rats. Therefore, locust powder is not expected to be toxic as a food material when acutely administered at a dose of 20 g/kg body weight.…”

Section: Resultsmentioning

confidence: 99%

“…From the results of biochemical parameters in plasma, no significant differences were observed in both sub‐chronic toxicological experiments. No aggravations in the plasma biochemical parameters of rats were reported from the chronic feeding investigations using some edible insects ( Tenebrio molitor , Pachymerus nucleorum , and Protaetia brevitarsis ; Alves et al., ; Han et al., ; Noh et al., ) From the results of hematological parameters, the values of RBC, hemoglobin, and hematocrit were significantly lower in rats fed locust powder containing diets (1% and 3%), but the differences were limited in the 28‐day sub‐chronic toxicological experiments. These differences are considered to be a transient event as the plasma levels of iron and other parameters were not significantly changed in both experiments.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, safety evaluations of edible insects have been increasingly conducted for utilization as human foods (Alves et al., ; Han et al., ; Noh et al., ). In acute toxicological experiments, general signs of toxicity and behavior changes were not observed, and body weight gain and food intake of rats was not changed by locust powder when compared to the control group (Figure ).…”

Section: Resultsmentioning

confidence: 99%

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Nutritional and safety evaluation of locust (Caelifera) powder as a novel food material

Ochiai

Inada

Horiguchi

2020

Journal of Food Science

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Insects are considered edible food resources with sufficient nutrients, but their nutrient composition and safety evaluation have not been fully investigated yet. In this study, we investigated the nutrient composition and the acute and sub-chronic toxicity of locust powder in male rats. In the acute oral toxicological experiment, rats were administered locust powder at a dose of 10 or 20 g/kg/dose, followed by monitoring general signs of toxicity for 14 days. In the sub-chronic toxicological experiments, rats were fed with a diet containing 1% and 3% locust powder for 28 and 90 days. General signs of toxicity, body weight, plasma and blood components, weight and fat accumulation in tissues, and fecal fat excretion were investigated. The locust powder was rich in proteins, essential amino acids, minerals, and polyunsaturated fatty acids. In the acute toxicological experiment, no general signs of acute toxicity were observed at a dose of 20 g/kg. In the sub-chronic toxicological experiments, parameters related to red blood cell were lowered by the 3% locust powder for 28 days, but not for 90 days. Liver lipid accumulation and fecal fat excretion were increased by the 3% locust powder for 90 days, but the liver lipids contents were considered to be within a nontoxic level. Cecum contents and cecum short-chain fatty acids were lowered by the locust powder, which can be caused by its fiber and fiber-like components. In conclusion, acute and sub-chronic intake of locust powder had little effect on general, biochemical, and hematological signs of toxicity in rats.Practical Application: Edible insects are increasingly viewed as new sustainable protein sources for human foods and livestock feeds worldwide because of their high nutritional balance, high food conversion rate, and environmental merits. Here, we have clarified that a locust powder contains high levels of protein, polyunsaturated functional fatty acids, and minerals (iron, zinc, and magnesium), and intake of locust powder (3% in diet) had little effects on general, biochemical, and hematological signs of toxicity in male rats. Locust as an edible insect, in powder form, can contribute to human dietary needs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Nutritional and safety evaluation of locust (Caelifera) powder as a novel food material

Ochiai

Inada

Horiguchi

2020

Journal of Food Science

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“…However, toxicity and quality control issues associated with alternative medicines for public consumption are areas of increasing concern due to the lack of scientific documentation regarding their toxicity (Shin, Lee, Kim, et al., 2012 ). In a 13‐week oral repeated dose toxicity study, (Noh et al., 2018 ) reported that PBE shows no toxicity up to 3,000 mg/kg. In this study, we did not observe any significant changes in bodyweight and hepatic enzyme activities among experimental groups during the experimental period.…”

Section: Discussionmentioning

confidence: 99%

Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats

Seo

Shin

Nam

et al. 2021

Food Science & Nutrition

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“…PBS is a species of the family Coleoptera found in East Asia and Europe (Noh et al . 2018). PBS at different growth stages have been reported to possess high antioxidant effects, and antimicrobial peptides protaetins can also be purified from PBS larvae (Yoon et al .…”

Section: Introductionmentioning

confidence: 99%

Effects of Protaetia brevitarsis seulensis powder dietary inclusion level on antioxidant activities of broiler breast meat during storage

Choi

Chung

2021

Entomological Research

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The present study aimed to evaluate the effects of Protaetia brevitarsis seulensis (PBS) powder dietary inclusion levels on the antioxidant activities of broiler breast meat during storage. A total of 270 Arbor Acres broiler chicks were randomly allocated to three treatments (3 replicates with 30 birds per pen), fed diets with inclusion of 0%, 0.5% or 1% PBS powder, in a completely randomized design. After slaughtering, samples were packed and stored at 4°C for later analysis of broiler breast meat. Antioxidant analysis included measurement of pH, thiobarbituric acid reactive substances (TBARS), and 1, 1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging activity. All samples were measured at storage days 0 and 7 as three replicates. For breast meat, changes were observed in pH, TBARS values, and DPPH radical scavenging at storage days 0 and 7 (p < 0.05), except for TBARS values at storage day 0. Overall, the addition of PBS powder resulted in lower TBARS values and higher DPPH radical scavenging in broiler breast meat during storage. Based on these results, it can be concluded that the addition of 0.5% and 1% PBS powder to broiler diets was effective at reducing lipid oxidation during storage, which could be related to the subsequent lower meat pH.

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Toxicological safety evaluation of freeze-dried Protaetia brevitarsis larva powder

Cited by 21 publications

References 17 publications

Nutritional and safety evaluation of locust (Caelifera) powder as a novel food material

Nutritional and safety evaluation of locust (Caelifera) powder as a novel food material

Effects of larval extracts from identified Protaetia brevitarsis seulensis against benign prostatic hyperplasia induced by testosterone in rats

Effects of Protaetia brevitarsis seulensis powder dietary inclusion level on antioxidant activities of broiler breast meat during storage

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