Toxicological responses of Cyprinus carpio after exposure to a commercial herbicide containing imazethapyr and imazapic

Moraes, Bibiana Silveira; Clasen, Bárbara; Loro, Vânia Lúcia; Pretto, Alexandra; Toni, Cândida; Avila, Luis Antônio de; Marchesan, Enio; Machado, Sérgio Luiz de Oliveira; Zanella, Renato; Reimche, Geovane Boschmann

doi:10.1016/j.ecoenv.2009.05.013

Cited by 62 publications

(38 citation statements)

References 44 publications

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“…Thus, results concerning GST activity suggest possible liver oxidative damage that disrupted the detoxification process. In agreement with our result, Moraes et al (2009b) observed decreased liver GST activity in carp after exposure to imazethapyr and imazapic in a similar rice field condition. Similarly, GST activity was decreased in Oreochromis niloticus exposed to oxyfluorfen (Peixoto et al, 2006).…”

Section: Discussionsupporting

confidence: 95%

Oxidative stress biomarkers in Cyprinus carpio exposed to commercial herbicide bispyribac‐sodium

Toni¹,

Menezes²,

Loro³

et al. 2010

J of Applied Toxicology

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Cyprinus carpio were exposed under field conditions to 20.87 microg l(-1) of commercial herbicide bispyribac-sodium (Nominee, SC), during 7, 21 and 72 days. Enzymatic parameters such as catalase (CAT), glutathione S-transferase (GST) and acetylcholinesterase (AChE) activities, as well as thiobarbituric acid-reactive substances (TBARS) and protein carbonyl contents were studied in different tissues. After 7 days of exposure, GST activity decreased. At the same period, brain AChE activity increased, but a reduction of activity was observed in muscle tissue. Brain TBARS levels increased at 7 days. After 21 days of exposure liver CAT levels and muscle AChE activities decreased. In the same period, liver protein carbonyl and muscle TBARS increased. After 72 days of exposure in the field, AChE activity was reduced in both brain and muscle. Protein carbonyl contents in liver and brain TBARS levels increased. Muscle AChE activity, TBARS and protein carbonyl can be used as biomarkers of exposure to the herbicide bispyribac-sodium. This study demonstrates effects of exposure to bispyribac-sodium under rice field conditions on oxidative stress parameters in tissues of Cyprinus carpio.

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Section: Discussionsupporting

confidence: 95%

Oxidative stress biomarkers in Cyprinus carpio exposed to commercial herbicide bispyribac‐sodium

Toni¹,

Menezes²,

Loro³

et al. 2010

J of Applied Toxicology

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“…Many works have been show changes in GST activity in the organs of fish exposed to different pesticides used in rice culture Moraes et al, 2011;Clasen et al, 2012;Toni et al, 2013). The lower GST activity in fish from river may be due to exposure to a different complex mixture and the hydrodynamics of contaminants from the river.…”

Section: Discussionmentioning

confidence: 99%

Spatial and temporal biomarkers responses of Astyanax jacuhiensis (Cope, 1894)(Characiformes: Characidae) from the middle rio Uruguai, Brazil

et al. 2015

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Due to intense agricultural activity in the rio Uruguai (South Brazil), there is the potential for aquatic contamination by agrochemicals. In this region, there are many reservoirs to meet the water demand for rice fields, forming lentic environments. In line with this information, the aim of this study was to show a comparative analysis of some biomarkers, such as lipid peroxidation (TBARS), gluthatione S-transferase (GST), non-protein thiols (NPSH), amino acids (AA) and piscine micronucleus tests (MNE) in Astyanax jacuhiensis from lentic and lotic environments in the middle rio Uruguai region, comparing warm and cold seasons. Eight pesticides were found in water samples, with propoxur having the highest concentration found in both environments and seasons. Fish from the warm season showed higher levels of biochemical biomarkers, and fish from the cold season showed higher levels of MNE and AA. TBARS and AA presented higher levels in fish from the river, while GST, NPSH, MNE and AA presented higher levels in fish from dams. These environments have different characteristics in terms of redox potential, aeration, sedimentation, trophic structure, agrochemicals input and others, which may affect the physiological and biochemical responses of fish in against adverse situations.Devido à intensa atividade agrícola no rio Uruguai (Sul do Brasil), há potencial para contaminação aquática por agrotóxicos. Há muitos reservatórios para atender a demanda de água de campos de arroz, formando ambientes lênticos. De acordo com estas informações, o objetivo do presente estudo foi mostrar uma análise comparativa de alguns biomarcadores como a peroxidação lipídica (TBARS), glutationa S-transferase (GST), tióis não-protéicos (NPSH), aminoácidos (AA) e teste písceo de micronúcleos (MNE) em Astyanax jacuhiensis amostrados em ambientes lóticos e lênticos da região do médio rio Uruguai, comparando estações quentes e frias. Oito pesticidas foram encontrados em amostras de água, sendo propoxur a maior concentração encontrada em ambos os ambientes e estações. Peixes da estação quente apresentaram maiores níveis de biomarcadores bioquímicos e peixes da estação fria apresentaram maiores níveis de MNE e AA. TBARS e AA apresentaram maiores níveis nos peixes de rio, enquanto GST, NPSH, MNE e AA apresentaram níveis mais elevados em peixes da represa. Estes ambientes têm características diferentes, com potencial redox, aeração, sedimentação, estrutura trófica, a entrada de agroquímicos e outros que podem afetar as respostas fisiológicas e bioquímicas de peixe contra situação adversa.

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“…after in vivo exposure of Cyprinus carpio to imazethapyr and imazapic (Moraes et al 2011), lindane and DDT in rats (Koner et al 1997) and malathion in humans (Seth et al 2001).…”

Section: Discussionmentioning

confidence: 99%

In vitroinhibition of blood cholinesterase activities from cattle by triazole fungicides

et al. 2013

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The changes in cattle acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities after exposure to tebuconazole-based fungicides (Orius and Prosaro ® ) in vitro were determined spectrophotometrically according to the Ellman method. The fungicides induced the decrease in AChE and BChE levels in a dose-dependent manner. Statistically significant inhibition of erythrocyte AChE levels was observed in the concentration range from 150 to 300 μg ml −1 (p < 0.001) for Orius and from 100 to 300 μg ml −1 for Prosaro ® (p < 0.01 and p < 0.001, respectively). Levels of BChE activity were more reduced for the fungicide Orius (40-50%) than for Prosaro ® . Statistical significance in the inhibition of BChE activity was found after exposure of cattle plasma to both fungicides at concentrations starting from 150 μg ml −1 (p < 0.001). Our results indicate that tebuconazole-based fungicides are able to reduce cattle AChE and BChE activities.

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Toxicological responses of Cyprinus carpio after exposure to a commercial herbicide containing imazethapyr and imazapic

Cited by 62 publications

References 44 publications

Oxidative stress biomarkers in Cyprinus carpio exposed to commercial herbicide bispyribac‐sodium

Oxidative stress biomarkers in Cyprinus carpio exposed to commercial herbicide bispyribac‐sodium

Spatial and temporal biomarkers responses of Astyanax jacuhiensis (Cope, 1894)(Characiformes: Characidae) from the middle rio Uruguai, Brazil

In vitroinhibition of blood cholinesterase activities from cattle by triazole fungicides

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