Toxicological Profile of Carbaryl

Blacker, Ann M.; Lunchick, Curt; Lasserre-Bigot, Dominique; Payraudeau, Virginie; Krolski, Mike E.

doi:10.1016/b978-0-12-374367-1.00074-4

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Carbaryl and diazinon used in this study are only a few of these pesticides. Carbaryl (1-naphthyl methylcarbamate) is an insecticide in the carbamate family [5] and diazinon is an organophosphate insecticide [6]. Carbaryl is used around the world to control insects on forests, nuts, fruit, citrus, cotton and etc.…”

Section: Introductionmentioning

confidence: 99%

Bazı Pestisitlerin Lipaz Enzimi Üzerine Etkisinin In vitro Koşullarda İncelenmesi

Paluzar

2021

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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It is known that the enzyme activities of non-target organisms are influenced in vivo or in vitro by pesticides that play a major role to obtain higher yields in the field of agriculture. It is foreseen that the pesticides used for various purposes may negatively affect lipase, an enzyme of the digestive system, of the non target organisms. Therefore, in this study, in vitro effect of diazinon (organophosphate class) and carbaryl (carbamate class) pesticides, which are known to be widely used in agriculture, was investigated and an effective dosage range of these pesticides on lipase enzyme was determined. It was observed that the lipase enzyme treated with diazinon and carbaryl in the concentration range of 100-2500 ppm was inhibited. Lipase enzyme activity at maximum diazinon concentration was calculated as 2.05%. Carbaryl completely inhibited lipase at maximum concentration The Kinetics conformed to the Michaelis-Menten model and a Lineweaver-Burk graph of the lipase was drawn. Carbaryl showed the strongest inhibitory effect against lipase (Ki: 460.96±28.25 mM; IC50: 2.5±1.3 µM) in comparison to diazinon. In the case of diazinon, Ki and IC50 value were found as 481.32±45.18mM and 3.6±0.9 µM for the lipase, respectively. The results showed that C. rugosa lipase are inhibited by diazinon and carbryl in vitro. It was shown that the catalytic activity of C. rugosa lipase is inhibited competitively by carbaryl but noncompetitively by diazinon

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Section: Introductionmentioning

confidence: 99%

Bazı Pestisitlerin Lipaz Enzimi Üzerine Etkisinin In vitro Koşullarda İncelenmesi

Paluzar

2021

Düzce Üniversitesi Bilim Ve Teknoloji Dergisi

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“…The half-life of this gastrointestinal exposure is roughly 5-10 hours (depending on the pesticide) and symptoms of irritation can be seen almost immediately following ingestion. In addition to ingestion, dermal absorption is another route for non-occupational exposures and accounts for 19-57% of the way the general population are exposed to pesticides (Blacker et al, 2010b). Dermal exposure is typically low among humans (roughly 1.5%) in non-occupational settings, but this can increase based on the type of insecticide and its absorption, the length of exposure, the weather during application, and whether proper personal protective equipment (PPE) was utilized (Blacker et al, 2010a;Blacker, et al, 2010b).…”

Section: Routes Of Exposure: Inhalation Ingestion Dermalmentioning

confidence: 99%

Utilizing urinary biomarkers in Egyptian adolescent applicators and non-applicators to characterize pesticide exposure to λ-cyhalothrin, α-cypermethrin, chlorpyrifos and profenofos applied on cotton crops over time

Okeke¹

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who provided me with guidance, encouragement, and a unique scientific perspective that provided me with the environment necessary for success. I am especially grateful for Dr. Diane Rohlman, my committee chair. This journey has not always been an easy one, but I am thankful for your commitment to me as your mentee and your dedication to helping me grow as a scientist in this field. With this came some tough conversations and difficult decisions, but I am eternally grateful for the woman, better yet, the Toxicologist, you've pushed me to become. Thank you, Diane. I would also like to thank Dr. Ludewig, the Director of Graduate Students for the Human Toxicology program. I want to say thank you for all of the times you've allowed me in your office for laughter, encouragement and sometimes tears. Though my stint in Iowa has brought about some difficult situations, thank you for always encouraging me to see the bigger picture. I want to thank my officemates, Kate, Josie and Maya. I did not know what to expect when I moved into Joel's old office space, but I am grateful that we all crossed paths. Maya, you have truly become a part of my support system and I am thankful for all of the wisdom, the encouragement, and the bad jokes we've shared these last few years. To those who became a part of my village in Iowa, I am eternally grateful. Rondine, Ashlei, Taimyr, Thapelo, Victoria, Roseina, Ashley, Zana, and every other amazing woman I have crossed paths with while in Iowa, thank you. Often times it is difficult to articulate the double consciousness we live while navigating academia as Black women and having you all in my circle who just get it, made Iowa that much more v amazing. Thank you for all of the support, the late-nights, the 'we in this together' talks, and for each of you being a light in your respective fields and across the University of Iowa's campus. I would like to especially thank Ashlei, Taimyr and Rondine. I am not sure I would have survived graduate school without you three amazing and brilliant women. Thank you. To my lifelong friends/sisters, Charda, Toni, Sara, Ebony, Courtney, Minisha, and Alania, thank you for always supporting me no matter how near or far our paths take us. From the "I need to get away" trips to the "let's just sit in the house and do nothing" adventures, you women have literally become a cornerstone for me. Thank you for always pushing me, showing up (and out haha!), and being the genuine friends, I did not know I needed but am grateful I found. Lastly, I'd like to thank my family. To my older brother, thank you for all of the wise words you've shared over the years. I know if I ever need a laugh, that you will always be there to change my frown into a smile. To my younger siblings, thank you for being my biggest fans. You all are my motivation for continuing to push myself further and farther each day. To my mother, one of the strongest women I know, through all of her life experiences she made sure that each of her five children never stopped believing that they could achieve...

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The sensitivity of the zebrafish embryo coiling assay for the detection of neurotoxicity by compounds with diverse modes of action

Hellfeld

Gade

Baumann

et al. 2023

Environ Sci Pollut Res

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In the aim to determine neurotoxicity, new methods are being validated, including tests and test batteries comprising in vitro and in vivo approaches. Alternative test models such as the zebrafish (Danio rerio) embryo have received increasing attention, with minor modifications of the fish embryo toxicity test (FET; OECD TG 236) as a tool to assess behavioral endpoints related to neurotoxicity during early developmental stages. The spontaneous tail movement assay, also known as coiling assay, assesses the development of random movement into complex behavioral patterns and has proven sensitive to acetylcholine esterase inhibitors at sublethal concentrations. The present study explored the sensitivity of the assay to neurotoxicants with other modes of action (MoAs). Here, five compounds with diverse MoAs were tested at sublethal concentrations: acrylamide, carbaryl, hexachlorophene, ibuprofen, and rotenone. While carbaryl, hexachlorophene, and rotenone consistently induced severe behavioral alterations by ~ 30 h post fertilization (hpf), acrylamide and ibuprofen expressed time- and/or concentration-dependent effects. At 37–38 hpf, additional observations revealed behavioral changes during dark phases with a strict concentration-dependency. The study documented the applicability of the coiling assay to MoA-dependent behavioral alterations at sublethal concentrations, underlining its potential as a component of a neurotoxicity test battery.

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Toxicological Profile of Carbaryl

Cited by 4 publications

References 10 publications

Bazı Pestisitlerin Lipaz Enzimi Üzerine Etkisinin In vitro Koşullarda İncelenmesi

Bazı Pestisitlerin Lipaz Enzimi Üzerine Etkisinin In vitro Koşullarda İncelenmesi

Utilizing urinary biomarkers in Egyptian adolescent applicators and non-applicators to characterize pesticide exposure to λ-cyhalothrin, α-cypermethrin, chlorpyrifos and profenofos applied on cotton crops over time

The sensitivity of the zebrafish embryo coiling assay for the detection of neurotoxicity by compounds with diverse modes of action

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