Toxicological Investigations of Ethanolic Leaves Extract of Dissothis thollonii (Melastomataceae)

Abstract

Dissotis thollonii is widely used in Cameroon for the treatment of typhoid fever, gastrointestinal disorders, inflammation, kidney diseases, pregnancy control and sinusitis. However there is lack of experimental data on its possible toxicity. The aim was to investigate acute and subchronic toxicity of the ethanol leaf extract of Dissotis thollonii in healthy Wistar rats. In acute toxicity tests, a single administration of the ethanolic leaf extract (5000 mg/kg) of Dissotis thollonii was given orally to 4 female rats. The general behavior, adverse effects, and mortality were recorded for up to 14 days post-treatment. On the 15 th day, the rats were weighed and euthanized for necropsy. In sub-chronic toxicity tests, the extract (18.28; 62.50; 250 and 1000

Antihypernociceptive, Anxiolytic, and Antidepressant Properties of Aqueous and Ethanol Extracts ofDissotis tholloniiCogn. (Melastomataceae) in Mice

“…thollonii , which is a pantropical plant from the Melastomataceae family. It is traditionally used to treat sinusitis, typhoid fever, inflammatory diseases, and gastrointestinal disorders [ 22 ]. The plant has proven numerous activities such as antidiarrheic, antibacterial, antimicrobial, antioxidant, and antiulcerogenic activities [ 23 – 25 ].…”

In Vitro Anti-Inflammatory and In Vivo Antiarthritic Activities of Aqueous and Ethanolic Extracts of Dissotis thollonii Cogn. (Melastomataceae) in Rats

“…Comprising about 163 genera, the family of Melastomataceae which are mainly pantropical plants include more than 4,300 species so many of them are known for their effectiveness in traditional medicine as antihepatitic, antihypertensive, anti-inflammatory, antihyperglycaemic, antioxidant, hemostatic, and antidiarrheal [19–24]. Dissotis thollonii ( D. thollonii ) is one of many species of the family of Melastomataceae used in traditional medicine in Cameroon to treat typhoid fever, gastrointestinal disorders, inflammatory diseases, and sinusitis [25–27]. The leaves are recommended for the treatment of ulcers and gastrointestinal disorders.…”

“…In addition, the work of TadjouaTchoumbou et al [24] showed that this plant significantly inhibited leukocyte migration in peritoneal fluid, intracellular ROS production, proliferation of Hela cell lines, and TNF- α production. Tala et al [27] showed that aqueous and ethanolic extracts were devoid of toxicity after 28 days of daily treatment. Similarly, Nono et al [30] showed the antimicrobial and antioxidant properties of this plant.…”