Toxicological inhalation studies in rats to substantiate grouping of zinc oxide nanoforms
Tizia Thoma,
Lan Ma-Hock,
Steffen Schneider
et al.
Abstract:Background
Different zinc oxide (ZnO) nanoforms were identified as a probable set of similar nanoforms for a common hazard assessment. To justify this grouping, toxicological studies were performed: A 90-day inhalation study (OECD test guideline no. (TG) 413) combined with a reproduction/developmental (neuro)toxicity screening test (TG 421/424/426) was performed in rats with coated and uncoated ZnO nanoforms in comparison with microscale ZnO particles and soluble zinc sulfate. In addition, genotoxicity in the… Show more
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