Toxicological impact of technical imidacloprid on ovarian morphology, hormones and antioxidant enzymes in female rats

Kapoor, Upasana; Srivastava, M. K.; Srivastava, L.P.

doi:10.1016/j.fct.2011.09.009

Cited by 140 publications

(109 citation statements)

References 28 publications

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“…Oxidative stress is a part of IMI toxicity that has been evidenced by earlier studies (16)(17)(18)(19). Our study has added to this knowledge by showing that IMI toxicity varies with sex, tissue, and exposure duration.…”

Section: Resultssupporting

confidence: 55%

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Sex-, tissue-, and exposure duration-dependent effects of imidacloprid modulated by piperonyl butoxide and menadione in rats. Part I: oxidative and neurotoxic potentials

Yardimci

Sevgiler

Rencüzoğulları

et al. 2014

Archives of Industrial Hygiene and Toxicology

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Earlier research has evidenced the oxidative and neurotoxic potential of imidacloprid, a neonicotinoid insecticide, in different animal species. The primary aim of this study was to determine how metabolic modulators piperonyl butoxide and menadione affect imidacloprid's adverse action in the liver and kidney of Sprague-Dawley rats of both sexes. The animals were exposed to imidacloprid alone (170 mg kg -1 ) or in combination with piperonyl butoxide (100 mg kg -1 ) or menadione (25 mg kg -1 ) for 12 and 24 h. Their liver and kidney homogenates were analysed spectrophotometrically for glutathione peroxidase, glutathione S-transferase, catalase, total cholinesterase specific activities, total glutathione, total protein content, and lipid peroxidation levels. Imidacloprid displayed its prooxidative and neurotoxic effects predominantly in the kidney of male rats after 24 h of exposure. Our findings suggest that the observed differences in prooxidative and neurotoxic potential of imidacloprid could be related to differences in its metabolism between the sexes. Co-exposure (90-min pre-treatment) with piperonyl butoxide or menadione revealed tissue-specific effect of imidacloprid on total cholinesterase activity. Increased cholinesterase activity in the kidney could be an adaptive response to imidacloprid-induced oxidative stress. In the male rat liver, co-exposure with piperonyl butoxide or menadione exacerbated imidacloprid toxicity. In female rats, imidacloprid+menadione co-exposure caused prooxidative effects, while no such effects were observed with imidacloprid alone or menadione alone. In conclusion, sex-, tissue-, and duration-specific effects of imidacloprid are remarkable points in its toxicity.

show abstract

Section: Resultssupporting

confidence: 55%

“…Many studies have shown the oxidative and neurotoxic potential of IMI in a variety of animal species, including rats (12)(13)(14)(15)(16)(17)(18)(19). However, none has investigated how biotransformation affects prooxidative and neurotoxic effects of IMI in mammals and whether it depends on sex, tissue, or exposure duration.…”

mentioning

confidence: 99%

Sex-, tissue-, and exposure duration-dependent effects of imidacloprid modulated by piperonyl butoxide and menadione in rats. Part I: oxidative and neurotoxic potentials

Yardimci

Sevgiler

Rencüzoğulları

et al. 2014

Archives of Industrial Hygiene and Toxicology

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show abstract

“…It has already been shown in previous studies [22,29] that IMI induced elevation of hepatic enzymes. Thus, the observed elevation in these enzymes could be due to liver dysfunction attributed to the damaging effect of IMI on liver cell membrane, which is in line with the study of Awad et al [30] who found a good correlation between cell damage and the enzyme leakage.…”

Section: Discussionmentioning

confidence: 92%

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Chakroun¹,

Grissa²,

Ezzi³

et al. 2017

JCLM

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“…Çalışmamızda da siyatik sinirlerin, 1x10 -3 M asetamiprid ile 120 dakika inkübasyonundan sonra, MDA düzeyinin kontrole göre önemli biçimde arttığı tespit edilmiştir. 20 mg/ kg imidakloprid'in dişi Rattus norvigicus'a (sıçan) 90 gün boyunca oral yolla verilen kronik çalışmada, ovaryum izole edilerek LPO düzeyinin, kontrole göre önemli biçimde arttığı CAT, SOD ve GPx aktivitesinin ise azaldığı anlaşılmıştır (43). Bu çalışmada, 5 ve 10 mg/kg imidakloprid'in herhangi bir etki göstermemesine rağmen, 20 mg/kg imidakloprid'in bu parametreleri değiştirmesi konsantrasyona bağlı etkiyi göstermektedir.…”

Section: Biyokimyasal Analizlerunclassified

Asetamiprid ve d-Tübokürarin'in Kurbağa Sinir Dokusu Üzerine Etkilerinin İncelenmesi (I: Oksidatif Potansiyel)

Çamlica¹,

Bediz²,

Yalın³

2016

Marmara Pharmaceutical Journal

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Toxicological impact of technical imidacloprid on ovarian morphology, hormones and antioxidant enzymes in female rats

Cited by 140 publications

References 28 publications

Sex-, tissue-, and exposure duration-dependent effects of imidacloprid modulated by piperonyl butoxide and menadione in rats. Part I: oxidative and neurotoxic potentials

Sex-, tissue-, and exposure duration-dependent effects of imidacloprid modulated by piperonyl butoxide and menadione in rats. Part I: oxidative and neurotoxic potentials

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

Asetamiprid ve d-Tübokürarin'in Kurbağa Sinir Dokusu Üzerine Etkilerinin İncelenmesi (I: Oksidatif Potansiyel)

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