Toxicological Evaluation of Some Essential Oils Obtained from Selected Romania Lamiaceae Species in Complex with Hydroxypropyl - gamma-cyclodextrin

Abstract

Medicinal plants are highly investigated due to their multiple effects in human health. In the last two decades, plants belonging to Lamiaceae family have emerged as an important source of compounds with beneficial effects in various pathologies. Many species of the Lamiaceae family have a high volatile oil content which can be found in different parts of the plant. Some representative examples include Lavandula spp. Salvia spp. and Mentha spp. which are species with essential oils studied for antioxidant, antimicrobial and antitumor effects. The aim of this study was to evaluate the effect of six essential oils at skin level before and after encapsulation in hydroxypropyl-gamma-cyclodextrins. Results indicated that regardless of the tested form, the samples did not display an irritating or toxic effect at skin level, suggesting that the essential oils can be used in different formulations for topical application.

Synthesis and Preliminary Characterization of Polyurethane Matrices Used as a Drug Carrier for Bromelain

“…Slight and similar increases of these two skin parameters were observed in the case of these two samples (PUM_0 and PUM_1). The increases of TEWL and erythema indicate unpleasant processes, but it is very important to compare the amplitude of these changes with those of a well-known irritative agent such as sodium lauryl sulfate used as reference in the literature [37]: they found TEWL increases approx. 11 g/h/m 2 (only 4 units in our case) and around 90 arbitr.…”

Antimicrobial Potential and Phytochemical Profile of Wild and Cultivated Populations of Thyme (Thymus sp.) Growing in Western Romania

“…The EOs analyzed in the present paper were obtained from mixtures of subspecies (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) of the same species belonging to the genus Thymus, from a collection area. Therefore, oils with different characteristics were obtained from the five collection areas.…”

“…Thymus-based products are widely used both in human [9] and veterinary [10] medicine as cosmetic and alimentary additives [5]. The essential oil (EO) extracted from wild thyme populations is used in the food industry as a spice, in the pharmaceutical industry as an antimicrobial agent and in the medical field [11][12][13]. The chemical composition of the EO varies significantly from one species to another and sometimes even in the same species [14,15].…”

Obtaining and Characterization of a Polydisperse System Used as a Transmembrane Carrier for Isosorbide Derivatives

“…V.G. Gurita (Ciobotaru) and her team have reported increases of TEWA around 11 g/h/m 2 and of erythema index approximately 90 units using the same instruments in a 25-h experiment on the skin of healthy human volunteers (Gurita (Ciobotaru) et al, 2019 ). In another study of our team, SLS solution was used as reference in an assessment of the toxicological profile of betulin entrapped in a PU carrier (Borcan et al, 2018c ); they presented comparative values of TEWL and erythema between the PU samples and SLS at 6 days, and important increases were found in the case of the well-known irritative agent (around 4 g/h/m 2 for the transepidermal water loss and more than 175 units for erythema index).…”