Toxicological evaluation of 80% methanol extract of Ludwigia octovalvis (Jacq.) P.H. Raven leaves (Onagraceae) in BALB/c mice

Yakob, Haidar Kadum; Uyub, Abd. Manaf; Sulaiman, Shaida Fariza

doi:10.1016/j.jep.2012.05.035

Cited by 26 publications

(16 citation statements)

References 10 publications

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“…A large number of the world's populations, especially in developing countries, depend upon medicinal plants as an alternative and complimentary drugs therapy for various ailments. Some of the most common practices involve the use of crude plant extracts, which may contain a broad diversity of molecules with often unknown biological effects [1]. Since the medicinal plants are being used indiscriminately without notifying to their possible unhealthy or toxic effects, the World Health Organization has recommended that traditional plants used for the treatment of diseases need further scientific investigation on their toxic side effects [2].…”

Section: Introductionmentioning

confidence: 99%

Toxicological Study ofOcimum sanctumLinn Leaves: Hematological, Biochemical, and Histopathological Studies

Gautam

Goel

2014

Journal of Toxicology

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The present study was aimed to study the acute and subacute toxicity studies with orally administered 50% ethanolic leaves extract of Ocimum sanctum Linn (OSE). In acute toxicity tests, four groups of mice (n = 6/group/sex) were orally treated with doses of 200, 600, and 2000 mg/kg, and general behavior, adverse effects, and mortality were recorded for up to 14 days. In subacute toxicity study, rats received OSE by gavage at the doses of 200, 400, and 800 mg/kg/day (n = 6/group/sex) for 28 days, and biochemical, hematological, and histopathological changes in tissues (liver, kidney, spleen, heart, and testis/ovary) were determined. OSE did not produce any hazardous symptoms or death and CNS and ANS toxicities in the acute toxicity test. Subacute treatment with OSE did not show any change in body weight, food and water consumption, and hematological and biochemical profiles. In addition, no change was observed both in macroscopic and microscopic aspects of vital organs in rats. Our result showed that Ocimum sanctum extract could be safe for human use.

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Section: Introductionmentioning

confidence: 99%

Toxicological Study ofOcimum sanctumLinn Leaves: Hematological, Biochemical, and Histopathological Studies

Gautam

Goel

2014

Journal of Toxicology

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“…This is the first time that these mechanism modes are described for this species. Besides L. octovalvis is an interesting option as antidiabetic because it was described as innocuous according to the OECD [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Almost all parts of the plant have been reported as having several medicinal uses [ 8 , 9 ], among them, the antidiabetic use by Mexican and Indian healers [ 10 , 11 ], in which the boiled extract or the juice of the whole plant is used. Previous phytochemical studies have described the presence of flavonoids, phenolic acids, polyphenols, saponins, sterols, tannins, and triterpenoids [ 12 – 15 ] in different organs of this medicinal plant. Several pharmacological effects such as hypoglycaemic [ 8 ], antihyperglycaemic [ 16 , 17 ], and antiproliferative, in 3T3–L1 adipocytes [ 18 ], have been described through various models.…”

Section: Introductionmentioning

confidence: 99%

Identification of Digestive Enzyme Inhibitors from Ludwigia octovalvis (Jacq.) P.H.Raven

Ramírez

Herrera-Arellano

Tortoriello

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Current antiobesity and antidiabetic tools have been insufficient to curb these diseases and frequently cause side effects; therefore, new pancreatic lipase and α–glucosidase inhibitors could be excellent aids for the prevention and treatment of these diseases. The aim of this study was to identify, quantify, and characterize the chemical compounds with the highest degree of inhibitory activity of these enzymes, contained in a Ludwigia octovalvis hydroalcoholic extract. Chemical purification was performed by liquid–liquid separation and column chromatography. Inhibitory activities were measured in vitro, employing acarbose, orlistat, and a Camellia sinensis hydroalcoholic extract as references. For structural elucidation, Nuclear Magnetic Resonance was carried out, and High Performance Liquid Chromatography was used to quantify the compounds. For α–glucosidases, L. octovalvis hydroalcoholic extract and its ethyl acetate fraction showed half–maximal Inhibitory Concentration (IC50) values of 700 and 250 μg/mL, for lipase, 480 and 718 μg/mL, while C. sinensis showed 260 and 587 μg/mL. The most active compounds were identified as ethyl gallate (1, IC50 832 μM) and gallic acid (2, IC50 969 μM); both displayed competitive inhibition of α–glucosidases and isoorientin (3, IC50 201 μM), which displayed uncompetitive inhibition of lipase. These data could be useful in the development of a novel phytopharmaceutical drug.

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“…On a private level, the Nestle Group has released a fortified bouillon product in Africa under the brand name Maggi. Maggi is currently fortified with iodine as well as iron . Currently, fortified Maggi has been launched in Benin, Togo, Cameroon, Côte d'Ivoire, Nigeria, Senegal, Ghana, Niger, and Guinea .…”

Section: National Legislation Regarding the Production And Marketing mentioning

confidence: 99%

The global regulatory landscape regarding micronutrient fortification of condiments and seasonings

Mejía¹,

Bower

2015

Annals of the New York Academy of Sciences

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Fortification of staple foods has been a successful strategy for combatting micronutrient deficiency. Recently, fortification of condiments and seasonings has been considered as a new approach to mitigate micronutrient deficiencies worldwide. The regulatory environment of already existing programs must be examined to assess their safety, efficacy, and sustainability as this strategy expands globally. The objective of this review is to summarize the global regulatory landscape for the fortification of condiments and seasonings. Presently, legislation regarding the fortification of condiments and seasonings is primarily voluntary and limited to a few nations in Asia. The only dietary vehicles addressed are salt, soy sauce, and fish sauce, and the micronutrients addressed are iron and iodine. A marketingdriven introduction of fortified seasoning powders with iron, and indirectly with iodine, is also gaining popularity in Africa, Central America, and Caribbean countries. It is recommended that legislation regarding food fortification be mandatory in nature and follow established CODEX and World Trade Organization principles as well as World Health Organization/Food and Agriculture Organization of the United Nations fortification guidelines to ensure that these programs are safe, effective, and sustainable.

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Toxicological evaluation of 80% methanol extract of Ludwigia octovalvis (Jacq.) P.H. Raven leaves (Onagraceae) in BALB/c mice

Cited by 26 publications

References 10 publications

Toxicological Study ofOcimum sanctumLinn Leaves: Hematological, Biochemical, and Histopathological Studies

Toxicological Study ofOcimum sanctumLinn Leaves: Hematological, Biochemical, and Histopathological Studies

Identification of Digestive Enzyme Inhibitors from Ludwigia octovalvis (Jacq.) P.H.Raven

The global regulatory landscape regarding micronutrient fortification of condiments and seasonings

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