Toxicological evaluation of 2-dodecylcyclobutanone, a unique radiolytic compound of palmitic acid

Validation of an alternative method for the identification of 2‐dodecylcyclebutanone (2‐DCB) of irradiated meats by solid‐phase microextraction (SPME) gas chromatography–mass spectrometry (GC‐MS)

“…For this reason, ACBs can be used as chemical markers of irradiated lipid-containing foods. Several studies have been written on the toxicity of 2-ACBs reporting, through a series of in vivo and in vitro experiments, their cyto-and geno-toxicity (Marchioni et al, 2004;Hartwig et al, 2007;Hijaz et al, 2010;Song et al, 2018). In a normal diet, the intake of 2-DCB by humans, following consumption of irradiated foods, appears to be negligible due to the low percentage of irradiated food present at international market and the application of rigorous controls on radiation dose level according to national and international standards.…”

Potencial genotóxico >i<in vivo>/i< de 2-Alcilciclobutanonas provenientes de manteiga de cacau irradiada, em células hepáticas de ratos >i<Wistar>/i<

“…As 2-ACBs derivadas dos ácidos graxos saturados são: a 2-hexil-ciclobutanona, derivada do ácido caprílico (C10:0); 2-octil-ciclobutanona, derivada do ácido láurico (C12:0); 2-decil-ciclobutanona, derivada do ácido mirístico (C14:0); 2-dodecilciclobutanona, derivada do ácido palmítico (C16:0); 2-tetradecil-ciclobgutanona, derivada do ácido esteárico (C18:0) e as derivadas dos ácidos graxos insaturados são 2-(tetradec-5'-enil)-ciclobutanona, derivada do ácido oleico (C18:1) e 2-(tetradeca-5',8'-dienil)-ciclobutanona (GADGIL, et al, 2002;SONG et al, 2018). No quadro 1 estão representados os ácidos graxos precursores das 2-ACBs e os alimentos nos quais são mais frequentes quando são irradiados.…”