Toxicological evaluation for biomaterials: Examinations of radiation vulcanized natural rubber latex

Tsuchiya, Toshie; Ikarashi, Yoshiaki; Toyoda, Kazuhiro; Uchima, Takao; Miyahara, Taishi; Takahashi, Michihito; Nakamura, Akitada

doi:10.1016/1359-0197(92)90110-2

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…It owes its colloid stability to the presence of adsorbed proteins at the surface of the rubber particles. The cytotoxic and tissue irritative activities of radiation vulcanized NR (vNR) latex have been considered much weaker than sulfur‐vulcanized lattices 6. It is possible to take advantage of the development of novel polymers based on NR.…”

Section: Introductionmentioning

confidence: 99%

Creation of Hydrophobic Materials Fabricated from Soy Protein and Natural Rubber: Surface, Interface, and Properties

Tian

Zhang

et al. 2010

Macro Materials & Eng

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Hydrophobic materials were successfully prepared from SPI and NR by blending via freezing/lyophilizing. The interfacial interaction, surface properties, hydrophobicity, and mechanical properties, biodegradability as well as the biocompatibility were investigated. The blend sheets exhibited good interface adhesion and good optical transparency. Their hydrophobicity was significantly improved compared with pure soy protein sheets. XPS results proved the NR surface enrichment. Flexibility and toughness of the blend sheets were enhanced and phase inversion phenomena were observed. Furthermore, the blend sheets exhibited good biodegradability and biocompatibility capable of supporting cell adhesion and proliferation.

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Section: Introductionmentioning

confidence: 99%

Creation of Hydrophobic Materials Fabricated from Soy Protein and Natural Rubber: Surface, Interface, and Properties

Tian

Zhang

et al. 2010

Macro Materials & Eng

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“…Radiation vulcanization of natural rubber latex is an emerging technology whereby radiation is used in place of sulfur in the conventional prevulcanization process for the manufacture of dipped natural rubber latex products 1–4. The radiation‐vulcanized natural rubber latex (RVNRL) has many advantages over conventional vulcanizates such as the absence of N ‐nitrosamines, very low cytotoxicity, degradability, transparency, softness, low emission of SO 2 , and less formation of ashes when burned 5. These characteristics of RVNRL suggest its wide application in the medical field.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel coating of RVNRL film by electron-beam irradiation

Ratnam¹,

Yoshii²,

Makuuchi³

et al. 1999

J. Appl. Polym. Sci.

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The tackiness properties of radiation-vulcanized natural rubber latex (RVNRL) film surfaces coated by various monomers were investigated in order to define the suitable hydrogels which reduce the tackiness of the film. In this context, different types of monomers, namely, N-vinyl-2-pyrrolidone (NVP), N,N-dimethylaminoethylamide (DMAEA), acrylic acid (AAc), n-butyl acrylate (n-BA), and 2-hydroxyethyl methacrylate (HEMA) as well as the monomer mixtures were tried with varying degrees of success. Coating the RVNRL film with 80% HEMA/20% n-BA by irradiation at 80 kGy using a low-energy electron beam gave a remarkable reduction in the surface tackiness of the RVNRL film. Several other attempts were made such as priming the RVNRL film with acid and aluminum sulfate prior to coating, mixing the aluminum sulfate into the monomer mixtures, and dipping the partially wet RVNRL film into the monomer to enhance the wettability of the monomers with the film. The photomicrographs taken illustrate that the decrease in tackiness with the coating is due to the increase of the surface roughness at an 80-kGy irradiation dose. The studies also revealed that the reduction in the contact angle and the increase in water absorption of the RVNRL film after irradiation are due to the formation of the hydrogel layer.

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“…In order to use natural rubbers in the development of medical products (surgical gloves [10], blood arteries [11]) and components of medical instruments [12], of polymer systems intended for the controlled release of biologically active substances [13], and of fertilisers for agricultural crops [14], information is needed not only on the mechanical characteristics of the rubber compounds based on NR but also, primarily, on the diffusional behaviour (transport) of water and other low molecular weight components present in the elastic matrix. Taking into account the high mechanical characteristics of rubber compounds but their limited parameters of haemocompatibility (haemolytic activity of the rubber surface, the breakdown of erythrocytes [15]), and also bearing in mind the above arguments (the ecological aspect, the need to control diffusional transport), we are suggesting for the fi rst time that a new polymer composite be used that includes natural rubber and bacterial poly(3hydroxybutyrate) (PHB) as a biodegradable [16] and thromboresistant [17] material.…”

mentioning

confidence: 99%

Monitoring New Polymer Composites Based on Natural Rubber and Bacterial Poly(3-Hydroxy-Butyrate): The Fourier Ir Spectroscopy Method

Markin

Иорданский

Lyusova

et al. 2007

International Polymer Science and Technology

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Natural latices obtained from rubber plants (most commonly Hevea brasiliensis or Hevea Malasia) are the main source of natural rubber (NR). Rubber compounds based on NR possess excellent mechanical properties and are irreplaceable in areas such as the tyre industry, mechanical rubber goods production, the development of adhesive composites, vacuum technologies, industrial membrane technologies, medicine, etc. [1].

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Toxicological evaluation for biomaterials: Examinations of radiation vulcanized natural rubber latex

Cited by 4 publications

References 4 publications

Creation of Hydrophobic Materials Fabricated from Soy Protein and Natural Rubber: Surface, Interface, and Properties

Creation of Hydrophobic Materials Fabricated from Soy Protein and Natural Rubber: Surface, Interface, and Properties

Hydrogel coating of RVNRL film by electron-beam irradiation

Monitoring New Polymer Composites Based on Natural Rubber and Bacterial Poly(3-Hydroxy-Butyrate): The Fourier Ir Spectroscopy Method

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