Toxicological evaluation by in vitro and in vivo assays of an aqueous extract prepared from Echinodorus macrophyllus leaves

Lopes, Leonardo da Costa; Albano, Franco; Laranja, G.A.T.; Alves, Luciano Marques; Silva, Luis Fernando Martins e; Souza, Gabriele Poubel de; Araujo, Isabela de Magalhães; Nogueira-Neto, José Firmino; Felzenszwalb, Israel; Kovary, K

doi:10.1016/s0378-4274(00)00220-4

Cited by 67 publications

(20 citation statements)

References 11 publications

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“…The increase in the body weight of rats was found in both of the tested and control groups ( Table 1). This could be due to the stimulation of food intake which was clearly measured in this study or an effect on energy expenditure by body tissues 6 . No significant difference was observed in relative organ weight, except the relative liver weight which was lower in treated group than control group.…”

Section: Discussionmentioning

confidence: 74%

Acute Toxicity of the Aqueous Extract From Brillantaisia Vogeliana (Nées) Benth. (Acanthaceae)

Oumbe¹,

Pieme²,

Fewou³

et al. 2013

Int. J. Res. Ayurveda Pharm.

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Brillantaisia vogeliana (Acanthacées) is a plant used in the West-Cameroon traditional pharmacopeia. This species have been used to facilitate deliverance and delivery and to treat stomach ailment. The aqueous extract of leaves was studied by conventional pharmacological methods. Twelve female rats were randomly assigned in two groups of 6 animals each designated as control and treated groups. After a sighting study, one group of the fasted animals for 12h received a single oral dose of 2000 mg/kg body weight of aqueous solution of Brillantaisia vogeliana while control group received distilled water. Oral consumption of 2 g/kg of Brillantaisia vogeliana produced neither mortality nor significant differences in the body and relative organs weights except relative liver weight between control and treated animals. Moreover, no abnormality and no histopathological changes were detectable between both control and treated animals. Hematological analysis showed no difference in any of the parameters tested (WBC count, platelet, total leukocytes, RBC count, hematocrit and hemoglobin estimation) in either control or treated groups. No significant change occurred in the blood chemistry parameters, including creatinine, urea nitrogen (UN), alkaline phosphatase, aspartate amino transferase (ASAT), alanine aminotransferase (ALAT), calcium and phosphorus. However, α-amylase and total protein showed a significant difference between control and treated groups. The results showed the innocuity of the aqueous extract of B. vogeliana and thus validated its utilization in Cameroonian traditional pharmacopoeia. The LD50 was higher than 2g/kg of body weight and according to Globally Harmonized Hazard Classification and Labelling Scheme (GHS), aqueous extract of B. vogeliana was classified in group 5.

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Section: Discussionmentioning

confidence: 74%

Acute Toxicity of the Aqueous Extract From Brillantaisia Vogeliana (Nées) Benth. (Acanthaceae)

Oumbe¹,

Pieme²,

Fewou³

et al. 2013

Int. J. Res. Ayurveda Pharm.

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“…In vivo comet assay. After treatment and sacrifice of animals, blood lymphocytes and/or cells, dissociated from organs by mincing a small piece into very fine fragments, are treated as per the same protocols as in vitro studies (Chiu et al, 2000;da Costa Lopes et al, 2000;Cavalcanti et al, 2010). The in vivo comet assay detects low levels of DNA damage, requiring small numbers of cells per sample .…”

Section: Transgenic Rodent (Tgr) Mutation Assaymentioning

confidence: 99%

Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

Ouédraogo

Baudoux

Stévigny

et al. 2012

Journal of Ethnopharmacology

124

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“…The use of medicinal plants by traditional medicine practitioners (TMPs) in the management of several disorders dates back to time immemorial and is increasing in recent times [1]. A wide range of bioactive found in plants are used as phyto-pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Effect of Administration of Root Ethanolic Extract of Aristolochia Ringens on the Liver Functional Indices of Male Wistar Rats

Sulyman

Akolade²,

Na’Allah

et al. 2017

IJT

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Toxicological evaluation by in vitro and in vivo assays of an aqueous extract prepared from Echinodorus macrophyllus leaves

Cited by 67 publications

References 11 publications

Acute Toxicity of the Aqueous Extract From Brillantaisia Vogeliana (Nées) Benth. (Acanthaceae)

Acute Toxicity of the Aqueous Extract From Brillantaisia Vogeliana (Nées) Benth. (Acanthaceae)

Review of current and “omics” methods for assessing the toxicity (genotoxicity, teratogenicity and nephrotoxicity) of herbal medicines and mushrooms

Effect of Administration of Root Ethanolic Extract of Aristolochia Ringens on the Liver Functional Indices of Male Wistar Rats

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