Toxicological evaluation and anti-inflammatory potential of an ethanolic extract from Bromelia balansae (Bromeliaceae) fruit

Balin, Paola da Silva; Zanatta, Flavia Carina; Jorge, Bárbara Campos; Leitão, Maicon Matos; Kassuya, Roberto Mikio; Cardoso, Cláudia Andréa Lima; Kassuya, Cândida Aparecida Leite; Arena, Arielle Cristina

doi:10.1016/j.jep.2018.04.049

Cited by 10 publications

(6 citation statements)

References 34 publications

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“…Results different to this study were reported by Da Silva-Balin (34) a significant decrease in the relative weight of the kidney and liver by providing an ethanolic extract of Bromelia balansae, but no macroscopic alteration was found in the organs. 3.3 Hepatoxicity.…”

Section: Characterization Of Nanoparticlescontrasting

confidence: 99%

Toxicological and Genotoxicological evaluation of Chitosan Nanoparticles Loaded with Pinene in A Murine Model

2020

IJGHC

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Byrsonima crassifolia (Malpighiaceae) has been widely used in Mexican traditional medicine as a remedy for the treatment of depression and diabetes. Various monoterpenes and diterpenes, have been identified from the active extract and has been demonstrated their antifungal activity. The α-pinene is present mostly and was loaded in chitosan Nanoparticles (P-CSNP) by the nanoprecipitation method. The morphology, particle size distribution, Zeta potential, the identification of the functional groups presents in P-CSNP, the toxicity and genotoxicity were evaluated. The nanoparticles and nanoparticles based coatings (ECP-CSNP) were administering to mice for 28 days (2.5 mg/g). Show spherical shape nanoparticles with a particle size of 5 ± .07nm. The P-CSNP showed a binomial distribution in which 81.5% of its population had a size of 3.9 ± 0.5 nm and a Z potential of 13.4 to 14.9 mV. The P-CSNP showed similarities between the patterns of the FTIR spectra suggest the union of the α-pinene aromatic groups and the nanometric Toxicological … Gonzalo Hernández López et al.

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Section: Characterization Of Nanoparticlescontrasting

confidence: 99%

Toxicological and Genotoxicological evaluation of Chitosan Nanoparticles Loaded with Pinene in A Murine Model

2020

IJGHC

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“…Nonetheless, the oral use of B. balansae in Brazilian folk medicine, and the absence of reports regarding purgative effects thereby suggested low concentration of these laxative compounds (da Silva Balin et al, 2018;de Lima et al, 2019;Rocha et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Amongst the herbs which are known to have a variety of therapeutic uses is Bromelia balansae Mez. This vegetal is a Research, Society and Development, v. 10, n. 11, e411101118052, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org /10.33448/rsd-v10i11.18052 terrestrial Bromeliaceae native to South America which is employed as a cough suppressant in Brazilian folk medicine and also as an emergent and affordable source of cellulose for biotechnological and pharmaceutical applications (Corrêa et al, 2019;da Silva Balin et al, 2018;Romero et al, 2006). Despite its relevance and uses, B. balansae populations are decreasing owing to the advance of the monoculture of commodity crops in some regions of the Brazilian Cerrado, thereby leading to the need of repopulation interventions.…”

Section: Introductionmentioning

confidence: 99%

Influence of organo-mineral supplementation on the production of secondary metabolites in in vitro-germinated Bromelia balansae Mez.

Souza

Thomaz

Kloppel

et al. 2021

RSD

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This work details the investigation of the influence of organo-mineral supplementation on the production of secondary metabolites in in vitro-germinated Bromelia balansae Mez. The seeds were germinated in vitro and transplanted to standard soils to undergo organo-mineral supplementation. The fully-grown plants were subjected to qualitative phytopharmacological prospection; quantitative analysis of total phenols and flavonoids; as well as chemical profiling by mass spectrometry. The in vitro germination of B. balansae was successful, with a germination rate of 94.95 %, thereby equaling to “super seeds” reported in literature. Moreover, the organo-mineral supplementation enhances the production of secondary metabolites in both leaves and roots, what therefore leads to higher yield of total phenols and flavonoids. Furthermore, mass spectrometry analysis confirmed the results from phytopharmacological prospection, and allowed the detection of fragments of secondary metabolites from shikimate/polyketide/mevalonate pathways.

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“…All rats were observed in detail periodically and daily for 14 days for any toxic effects [ 26 ]. Intake of water and food, along with body weight, were measured daily [ 25 ].…”

Section: Methodsmentioning

confidence: 99%

Phytochemical and Safety Evaluations of Zingiber ottensii Valeton Essential Oil in Zebrafish Embryos and Rats

Thitinarongwate

Mektrirat

Nimlamool

et al. 2021

Toxics

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Zingiber ottensii Valeton (ZO) exhibits pharmacological activity and has long been used in traditional medicine. However, reports about its safety profiles are limited. The present study aimed to evaluate the phytochemical profile and the toxic effects of ZO essential oil on the development of zebrafish and acute oral toxicity in rats. The essential oil was isolated from ZO rhizomes, and phytochemicals were analyzed using a gas chromatography–mass spectrometer (GC–MS). The embryotoxic and teratogenic effects of ZO essential oil were evaluated in zebrafish embryos and larvae and the acute oral toxicity was determined in rats. GC–MS results showed the essential oil contained zerumbone as a major phytoconstituent (24.73%). The zebrafish embryotoxicity of ZO essential oil appeared to be concentration- and time-dependent manner, with a moderate LC50 (1.003 µg/mL). Teratogenicity in zebrafish embryos also included morphological defects, decreased hatchability, and reduced heart rate. In rats, ZO essential oil (2000 mg/kg, p.o.) resulted in no mortality or significant toxicities. These findings suggest that ZO has embryotoxic and teratogenic effects in zebrafish embryos but does not result in death or acute oral toxicity in rats. Further long-term toxicity studies are needed to confirm the safety of products developed from ZO essential oil.

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Toxicological evaluation and anti-inflammatory potential of an ethanolic extract from Bromelia balansae (Bromeliaceae) fruit

Abstract: These results show that EEBB has an anti-inflammatory potential without causing acute or subacute toxicity. These data may contribute to the advancement of biopharmaceutical applications for this species.

Cited by 10 publications

References 34 publications

Toxicological and Genotoxicological evaluation of Chitosan Nanoparticles Loaded with Pinene in A Murine Model

Toxicological and Genotoxicological evaluation of Chitosan Nanoparticles Loaded with Pinene in A Murine Model

Influence of organo-mineral supplementation on the production of secondary metabolites in in vitro-germinated Bromelia balansae Mez.

Phytochemical and Safety Evaluations of Zingiber ottensii Valeton Essential Oil in Zebrafish Embryos and Rats

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