Toxicological effects of short-term dietary acrylamide exposure in male F344 rats

Raju, Jayadev; Roberts, Jennifer; Taylor, Marnie; Patry, Dominique; Chomyshyn, Emily; Caldwell, Douglas R.; Cooke, Gerard M.; Mehta, Rekha

doi:10.1016/j.etap.2014.11.009

Cited by 35 publications

(39 citation statements)

References 28 publications

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“…According to Raju et al [8], AA increases calcium concentration in the blood, which may be manifested by increased calcification of this bone.…”

Section: Resultsmentioning

confidence: 99%

“…A few resorption lacunae were identified in these mice in pars anterior of the periosteal border. According to several authors [8][9]15] AA increases the oxidative stress and peroxidation of the lipids. The oxidative stress causes an increased production of reactive oxygen species (ROS) [16], which enhance osteoclastic activity [17] and bone resorption [18].…”

Section: Resultsmentioning

confidence: 99%

“…AA appears to be metabolized into glycidamid, forming a DNA-reactive epoxide that implies genotoxicity [7] and can interact with other proteins at the cellular level [8]. To our knowledge, there are no studies describing its influence on bone structure.…”

Section: Introductionmentioning

confidence: 94%

“…In human erythrocytes (in vitro), AA increases hemolysis and lipid peroxidation [8], suggesting that this neurotoxin affects redox status in cells [9]. The reported oral LD50 value is 107 mg/kg body weight (b.w.)…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Subacute Exposure to Acrylamide on Femoral Bone Microstructure in Laboratory Mice

Sarocka¹,

Babošová²,

Kováčová³

et al. 2016

Pol. J. Environ. Stud.

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Acrylamide, a substituted unsaturated hydrocarbon, is often found in fried potatoes, flour, baby food, coffee, and olives. It is one of the most commonly consumed neurotoxins by humans. To date, its effect on bone structure has not been investigated in experimental animals. The aim of our manuscript was to analyze the impact of subacute exposure to acrylamide on the microscopic compact and trabecular bone tissue structures in laboratory mice. Adult male mice were divided into two groups. Animals from the experimental group (group E, n = 4) were treated perorally with two doses of acrylamide (1 mg/kg b.w.) during 24 hours. The group without administration of AA served as a control (group C, n = 4). Three hours after the second dose of AA (after 27 hours), mice were killed and their femurs were used for microscopic analysis. Our results demonstrate that subacute exposure to acrylamide causes an absence of the primary vascular radial bone tissue in pars posterior of the endosteal border. Mice from E group had more intact secondary osteons in pars medialis of the middle part of compact bone. Also, a few resorption lacunae were found in pars anterior of periosteal borders in these mice. Subacute exposure to AA significantly decreased the size of the primary osteon vascular canals (P<0.05) in compact bone tissue. In trabecular bone tissue, the values for bone volume, trabecular number, and bone surface were significantly increased in mice from the E group. In contrast, the value for trabecular separation was significantly decreased in these mice.

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“…According to Raju et al [8], AA increases calcium concentration in the blood, which may be manifested by increased calcification of this bone.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Effect of Subacute Exposure to Acrylamide on Femoral Bone Microstructure in Laboratory Mice

Sarocka¹,

Babošová²,

Kováčová³

et al. 2016

Pol. J. Environ. Stud.

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“…Acrylamide is divided into a 2A class carcinogen by international agency for research on cancer (IARC, 1994), namely human possibly carcinogenic substance [1].A large number of animal poison rational tests showed that acrylamide produced nerve toxicity, genetic toxicity and carcinogenicity to animals which influence the health of human beings latently [2,3,4]. In 2002, people found that acrylamide were detected in coffee and frying and baking foods which were rich in starch (such as French fries, French Fried potatoes, cereals and bread, etc.)…”

Section: Introductionmentioning

confidence: 99%

Content and Formation of Acrylamide in Traditional Coffee Roast Programmes

Xu¹,

Yang²,

Zeng³

et al. 2016

Proceedings of the 2015 2nd International Conference on Machinery, Materials Engineering, Chemical Engineering and Biotechnolog

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Abstract. Since the taste, aroma, colour of coffee were the main indicators of traditional coffee roast programme, the content of acrylamide was defined as final standard in this paper. The least content of acrylamide produced in coffee roast process was picked out, and the formation rule of acrylamide was also explored. The results indicated that after roast programme one, the content of acrylamide was the least. The relevant process condition was as followings: when the input temperature was 205 and the output temper ℃ ature was 210 , the content of acrylamide at last ℃ was 117 ng/g, the rate of weight loss was 17.5%. The content of acrylamide in the whole programme increased at first but decreased near by the first burst(about 186 ) until finished. To ℃ reduce the content of acrylamide in roast programme, measures should taken such as shorten the time before the first burst and prolonged the heating time after that appropriatly to ensure further evaporation of acrylamid. The results provide theoretical basis and experience reference for reducing the content of acrylamide in roasted coffee.

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