Toxicological effects of ocular acrolein exposure to eyelids in rabbits in vivo

Gupta, Suneel; Martin, Lynn M.; Zhang, Eric; Sinha, Prashant R.; Landreneau, James R.; Sinha, Nishant R.; Hesemann, Nathan P.; Mohan, Rajiv R.

doi:10.1016/j.exer.2023.109575

Cited by 1 publication

(1 citation statement)

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“…The burn pit chemicals were chlorodifluormethane (also known as difluoromonochloromethane) with an ocular irritation of 0.77, methylene chloride (also known as dichloromethane) with an ocular irritation of 0.76, and acrolein, with an ocular irritation of 0.8. The specific ocular toxicities are independently referenced [22][23][24][25]. The ACD lab results from the Ohio train derailment in East Palestine were similarly analyzed.…”

Section: Resultsmentioning

confidence: 99%

An Assessment of the Ocular Toxicity of Two Major Sources of Environmental Exposure

Rauchman,

Kasselman,

Srivastava

et al. 2024

IJERPH

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The effect of airborne exposure on the eye surface is an area in need of exploration, particularly in light of the increasing number of incidents occurring in both civilian and military settings. In this study, in silico methods based on a platform comprising a portfolio of software applications and a technology ecosystem are used to test potential surface ocular toxicity in data presented from Iraqi burn pits and the East Palestine, Ohio, train derailment. The purpose of this analysis is to gain a better understanding of the long-term impact of such an exposure to the ocular surface and the manifestation of surface irritation, including dry eye disease. In silico methods were used to determine ocular irritation to chemical compounds. A list of such chemicals was introduced from a number of publicly available sources for burn pits and train derailment. The results demonstrated high ocular irritation scores for some chemicals present in these exposure events. Such an analysis is designed to provide guidance related to the needed ophthalmologic care and follow-up in individuals who have been in proximity to burn pits or the train derailment and those who will experience future toxic exposure.

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Section: Resultsmentioning

confidence: 99%