Toxicological effects of cadmium during pregnancy in Wistar albino rats

Aprioku, Jonah Sydney; Barikpoar, Ebenezer; Ijomah, Maxwell Azubuike

doi:10.1007/s13530-014-0183-z

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…This axis plays a crucial role in the control of development, reproduction, and aging . Some drug regimens are known to cause fluctuations in this axis with consequent deleterious derangement of reproductive functions …”

Section: Introductionmentioning

confidence: 99%

“…Cimetidine is an H 2 ‐receptor antagonist that blocks histamine action on H 2 ‐receptors in the parietal cells of the stomach, consequently inhibiting acid production . Its administration has been found to be associated with reproductive toxicity and it is thus described as a reproductive toxicant . Some of the deleterious reproductive effects of cimetidine include distortion of testicular histoarchitecture with marked degeneration of the seminiferous tubules and maturation arrest of spermatogenic cells, decreases in sperm motility and count, as well as impotence, with a resulting decrease in sexual drive and desire .…”

Section: Introductionmentioning

confidence: 99%

“…Its administration has been found to be associated with reproductive toxicity and it is thus described as a reproductive toxicant . Some of the deleterious reproductive effects of cimetidine include distortion of testicular histoarchitecture with marked degeneration of the seminiferous tubules and maturation arrest of spermatogenic cells, decreases in sperm motility and count, as well as impotence, with a resulting decrease in sexual drive and desire . Although the precise mechanism of cimetidine‐induced reproductive toxicity is uncertain, in males, cimetidine is known to target the hypothalamic‐pituitary‐testicular axis with associated structural changes in the histology of the testes .…”

Section: Introductionmentioning

confidence: 99%

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Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Onwuemene

Imafidon

Ayoka

2019

Anim Models and Exp Med

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Background The increasing incidence of chemically induced infertility is both a social threat and a threat to the continuation of life itself. Treatment or management therapy is often expensive. This study investigated the effects of acetone extract of a local plant (Curcuma longa) in a Wistar rat model of cimetidine‐induced pituitary‐testicular dysfunction. Methods Thirty‐five male Wistar rats were divided into 7 groups of 5 rats. After a phytochemical screening of an acetone extract of C. Longa, cimetidine and the extract at three doses, 200, 400 and 600 mg/kg, were orally co‐administered to the rats for 28 consecutive days. Comparisons were made (at P < 0.05) against a control (2 mL/kg distilled water), a standard treatment group (cimetidine + 50 mg/kg vitamin C), a toxic group (60 mg/kg cimetidine) and a group receiving extract alone. Results Cimetidine administration was associated with deleterious alterations to sperm motility, sperm count and sperm viability, as well as derangements in the plasma levels of FSH, LH and testosterone (P < 0.05). Both brain and testicular GSH and TBARS levels were significantly altered following cimetidine administration, and distortions were seen in the pituitary and testicular histoarchitecture. These changes were significantly normalized by co‐administration of graded doses of the extract, with an associated improvement of both pituitary and testicular histology. Conclusion Acetone extract of C. Longa normalized cimetidine‐induced pituitary‐testicular dysfunction in Wistar rats. This presents the extract as a potential nutraceutical choice against chemically induced reproductive toxicity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Onwuemene

Imafidon

Ayoka

2019

Anim Models and Exp Med

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“…All these are serious negative indices of pregnancy, which can independently affect the overall wellbeing of the developing embryo or fetus. [ 18 19 20 ] Implantation of the embryo follows egg fertilization and is essential for embryo development and sustenance of pregnancy. The presence of implantations was observed only in 2 (25%) of the rats that received 800 mg/kg, whereas implantations were retained in six animals (75%) that were administered 400 mg/kg of Calabash chalk.…”

Section: Discussionmentioning

confidence: 99%

Gestational toxicity of Calabash chalk (Nzu) in Wistar rats

Aprioku¹,

Ogwo-ude²

2018

Int J App Basic Med Res

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“…Previous studies reported that CdCl2 can induce recurrent abortion, alteration of Apgar 5-min score, decrease in birth weight, decrease forelimb and hindlimb bone lengths, poorer cognition, hydrocephalus, facial abnormalities, anophthalmia, and hepatic/placental cell necrosis (Aprioku et al, 2014;Jacobo-Estrada et al, 2017).…”

Section: Cadmium Chloride Was Listed By the Worldmentioning

confidence: 99%

Toxic Effect of Cadmium Chloride Exposure on Teeth Development in Sprague Dawley Rats During Pregnancy

Elhindawy

Helmy

Moawad

2021

Zagazig Journal of Forensic Medicine

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Background: Cadmium chloride (CdCl2) is a widely spread environmental toxin with reported developmental toxicity. Aim:The aim of the present work was to investigate the developmental toxicity of CdCl2 on rats' first molar histological structure, teeth mineralization through osteocalcin staining and evaluating caspase-3 expression as potential target, both intrauterine and after birth. Methods: Adult male and female Sprague Dawley rats were mated. Pregnant rats were divided into 2 groups, control group received water and experimental group received CdCl2 (5mg/kg) by oral gavage from 7 th to 17 th day of pregnancy. Two rats from control group and 8 rats from experimental group were sacrificed at gestational day 17 (GD17). Fifteen pups were obtained in control group and 10 pups in CdCl2 group. The day of parturition was deigned to be postnatal day (PND) zero (PND 0). From control group, 13 pups were sacrificed at PND10, and 13 pups at PND 20. From experimental groups, 12 pups were sacrificed at PND10, and 11 pups at PND 20. In all pups, heads were obtained for examining maxillary first molars. Results: Sections from the CdCl2 group showed delayed development, mineralization, and eruption of first molar than the control group in GD17, PND10 and PND 20. As regard osteocalcin, the expression pattern was the same in both groups, but the intensity of the expression decreased within the CdCl2 group with statistically significant difference between them. In addition, caspase-3 expression increased indicating apoptosis induction. Conclusion: Exposure to CdCl2 during pregnancy can lead to delay in the developmental stages of the first molar teeth beside its effect on the mineralization of dentin, the delayed teeth eruption and inducing apoptosis is a possible pathway for these effects.

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Toxicological effects of cadmium during pregnancy in Wistar albino rats

Cited by 6 publications

References 21 publications

Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Curcuma longa normalized cimetidine‐induced pituitary‐testicular dysfunction: Relevance in nutraceutical therapy

Gestational toxicity of Calabash chalk (Nzu) in Wistar rats

Toxic Effect of Cadmium Chloride Exposure on Teeth Development in Sprague Dawley Rats During Pregnancy

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