Toxicological assessment of nanoparticle interactions with the pulmonary system

Osman, Nashwa; Sexton, Darren W.; Saleem, Imran

doi:10.1080/17435390.2019.1661043

Cited by 44 publications

(24 citation statements)

References 234 publications

(287 reference statements)

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“…However, it will be difficult to remove the bigger nanoparticles. The nanoparticles can be rapidly cleared out either through the fast mucociliary action of the upper respiratory tract or across the alveolar macrophages [82].…”

Section: Toxicity Of Nanoparticlesmentioning

confidence: 99%

Nanotechnology-based promising strategies for the management of COVID-19: current development and constraints

Rai

Bonde

Yadav

et al. 2020

Expert Review of Anti-infective Therapy

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Introduction: COVID-19 pandemic has been declared as a global emergency by the World Health Organization which has mounted global pressure on the healthcare system. The design and development of rapid tests for the precise and early detection of infection are urgently needed to detect the disease and also for bulk screening of infected persons. The traditional drugs moderately control the symptoms, but so far, no specific drug has been discovered. The prime concern is to device novel tools for rapid and precise diagnosis, drug delivery, and effective therapies for coronavirus. In this context, nanotechnology offers novel ways to fight against COVID-19. Area covered: This review includes the use of nanomaterials for the control of COVID-19. The tools for diagnosis of coronavirus, nano-based vaccines, and nanoparticles as a drug delivery system for the treatment of virus infection have been discussed. The toxicity issues related to nanoparticles have also been addressed. Expert opinion: The research on nanotechnology-based diagnosis, drug delivery, and antiviral therapies is at a preliminary stage. The antiviral nanomedicine therapies are cost-effective and with high quality. Nanoparticles are a promising tool for prevention, diagnosis, antiviral drug delivery, and therapeutics, which may open up new avenues in the treatment of COVID-19.

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Section: Toxicity Of Nanoparticlesmentioning

confidence: 99%

Nanotechnology-based promising strategies for the management of COVID-19: current development and constraints

Rai

Bonde

Yadav

et al. 2020

Expert Review of Anti-infective Therapy

View full text Add to dashboard Cite

show abstract

“…Nanotechnology as a field has grown at a fast pace over the last 20 years, and has been responsible for the development of materials with useful properties for a plethora of industrial and biological applications in the engineering, communication, food, and textile industries, to name a few. Nanomaterials also have bioenvironmental applications, and can act as reliable drug carriers [ 144 ]. Nanoparticles (NPs) are sized less than 100 nm, and are characterized by an increased surface area and unique physicochemical properties, which make them extensively employed in several fields.…”

Section: Cellular and Molecular Mechanisms Of Toxicity On Hematopomentioning

confidence: 99%

“…Current nanomaterial research has mostly focused on nanotechnology applications, whereas there is little information regarding occupational and environmental exposure assessment and risk characterization associated with NPs. As airborne NPs are mainly absorbed by respiratory routes, some of the toxic effects of NPs on lungs have been described in both humans and experimental animals, being characterized mostly by inducible inflammatory reactions [ 144 ]. Still, inhaled NPs have a very small size and can be arrested from alveoli into other tissues by the bloodstream, which may lead to systemic harmful effects [ 148 ].…”

Section: Cellular and Molecular Mechanisms Of Toxicity On Hematopomentioning

confidence: 99%

Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis

Scharf

Broering

Rocha

et al. 2020

IJMS

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Hematopoiesis is a complex and intricate process that aims to replenish blood components in a constant fashion. It is orchestrated mostly by hematopoietic progenitor cells (hematopoietic stem cells (HSCs)) that are capable of self-renewal and differentiation. These cells can originate other cell subtypes that are responsible for maintaining vital functions, mediate innate and adaptive immune responses, provide tissues with oxygen, and control coagulation. Hematopoiesis in adults takes place in the bone marrow, which is endowed with an extensive vasculature conferring an intense flow of cells. A myriad of cell subtypes can be found in the bone marrow at different levels of activation, being also under constant action of an extensive amount of diverse chemical mediators and enzymatic systems. Bone marrow platelets, mature erythrocytes and leukocytes are delivered into the bloodstream readily available to meet body demands. Leukocytes circulate and reach different tissues, returning or not returning to the bloodstream. Senescent leukocytes, specially granulocytes, return to the bone marrow to be phagocytized by macrophages, restarting granulopoiesis. The constant high production and delivery of cells into the bloodstream, alongside the fact that blood cells can also circulate between tissues, makes the hematopoietic system a prime target for toxic agents to act upon, making the understanding of the bone marrow microenvironment vital for both toxicological sciences and risk assessment. Environmental and occupational pollutants, therapeutic molecules, drugs of abuse, and even nutritional status can directly affect progenitor cells at their differentiation and maturation stages, altering behavior and function of blood compounds and resulting in impaired immune responses, anemias, leukemias, and blood coagulation disturbances. This review aims to describe the most recently investigated molecular and cellular toxicity mechanisms of current major environmental pollutants on hematopoiesis in the bone marrow.

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“…Besides, many nanomaterials have crucial defects with biodegradation and excretion in the physiological environment due to their crystallinity with few defects that limit their in vivo application. 31 − 33 Meta-analysis studies on a large scale of NP delivery point out that over 99% of the applied dose of the nanomedicine cannot eventually accumulate in the tumor and some even remain in the body for over 2 years. 34 , 35 In addition to the medical effectiveness of PTT, the long-term safety of photothermic agents (PTAs) must also be considered.…”

Section: Introductionmentioning

confidence: 99%

Biosafety, Nontoxic Nanoparticles for VL–NIR Photothermal Therapy Against Oral Squamous Cell Carcinoma

Chen

Wang

et al. 2021

ACS Omega

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Semiconductor nanocrystals with extraordinary physicochemical and biosafety properties with unique nanostructures have shown tremendous potential as photothermal therapy (PTT) nanosensitizers. Herein, we successfully synthesized chiral molybdenum (Cys-MoO 3– x ) nanoparticles (NPs) for overcoming the general limitation on electron energy bands and biotoxicity. The obtained Cys-MoO 3– x NPs are selected as an ideal design for the treatment of oral squamous cell carcinoma (OSCC) cells through the decoration of cysteine molecules due to excellent initial photothermal spectral analysis of conductivity and light absorbance. Notably, NPs possess the ability to act as visible light (VL) and near-infrared (NIR) double-reactive agents to ablate cancer cells. By combining photoconductive PTT with hypotoxicity biochemotherapy, the treatment validity of OSCC cancer cells can be improved in vitro by up to 89% (808 nm) and get potential PTT effect under VL irradiation, which intuitively proved that the nontoxic NPs were lethally effective for cancer cells under laser irradiation. Hence, this work highlights a powerful and safe NP platform for NIR light-triggered PTT for use in head and neck cancer (HNC) cells, showing promising application prospects in oral tumor treatment.

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Toxicological assessment of nanoparticle interactions with the pulmonary system

Abstract: The version presented here may differ from the published version or from the version of the record. Please see the repository URL above for details on accessing the published version and note that access may require a subscription.

Cited by 44 publications

References 234 publications

Nanotechnology-based promising strategies for the management of COVID-19: current development and constraints

Nanotechnology-based promising strategies for the management of COVID-19: current development and constraints

Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis

Biosafety, Nontoxic Nanoparticles for VL–NIR Photothermal Therapy Against Oral Squamous Cell Carcinoma

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