This study is aimed at assessing the ability of metal-resistant yeast, Candida tropicalis, to uptake cadmium from the liquid medium. The minimum inhibitory concentration of Cd 2+ against C. tropicalis was 2,800 mg L −1 . The yeast also showed tolerance towards Zn 2+ (3,100 mg L −1 ), Ni 2+ (3,000 mg L −1 ), Hg 2+ (2,400 mg L −1 ), Cu 2+ (2,300 mg L −1 ), Cr 6+ (2,000 mg L −1 ), and Pb 2+ (1,200 mg L −1 ). The yeast isolate showed typical growth curves, but low specific rate of growth was observed in the presence of cadmium. The yeast isolate showed optimum growth at 30°C and pH 7. The metal processing ability of the isolate was determined in a medium containing 100 mg L −1 of Cd 2+ . C. tropicalis could decline Cd 2+ 57%, 69%, and 80% from the medium after 48, 96, and 144 h, respectively. C. tropicalis was also able to remove Cd 2+ 56% and 73% from the wastewater after 6 and 12 days, respectively. Cd produced an increase in glutathione (GSH) and non-protein thiol levels by 146.15% and 59.67% at 100 mg L −1 concentration, respectively. Metal tolerance and accumulation together with changes in the GSH status and non-protein thiols under Cd exposure were studied in C. tropicalis.