Toxicological and Pharmacological Studies on Dihydrorotenone*

Ambrose, Anthony M.; Christensen, Herbert E.; Rather, L. J.

doi:10.1002/jps.3030420615

Cited by 10 publications

(12 citation statements)

References 6 publications

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“…Teehni'cal chlordane is f,ormulated in varying strengths in different pesticidal preparations. Exposure to chlordane can occur through the intact skin, by inhalabon of dust or sprays, and by ingestion (2). Human poisonings and fatalities have been reported from dermal or oral exposure to chlordane (12,17,34).…”

Section: Environmental Distribution and Body Burden Of Chlordane And mentioning

confidence: 99%

Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

Infante¹,

Epstein²,

Newton³

1978

Scand J Work Environ Health

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& health 4 (1978) 137-150. In the United States, chlordane and heptachlor are commonly used in pesticide formulations for agricultural purposes and for termite eradication in the home. Pathological conditions possibly associated with prior exposure to such formulations are presented in this report. Five recently diagnosed cases of neuroblastoma associated with chlordane exposure during prenatal and postnatal development have been identified. Three cases of aplastic anemia and three cases of acute leukemia are also reported in association with chlordane formulations. The cases suggesting association between chlordane exposure and neuroblastoma are of interest in view of recent data on the carcinogenicity and mutagenicity of chlordane and heptachlor and in view of data on environmental distributions and body burdens. The cases of aplastic anemia and leukemia are of interest in view of previous literature reports on associations between chlordane and similar chlorinated hydrocarbon pesticides and blood dyscrasias, and in view of reports indicating that some subjects with aplastic anemia convert to leukemia. As previous studies are too limited to allow the development of valid inferences regarding the neoplastic risk of chlordane, there is need for formal epidemiologic study to evaluate health risks associated with chlordane through home exposure and through occupational exposure for termite exterminators, lawn care operators, and for workers in the agricultural setting.

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Section: Environmental Distribution and Body Burden Of Chlordane And mentioning

confidence: 99%

Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

Infante¹,

Epstein²,

Newton³

1978

Scand J Work Environ Health

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“…Datta et al [1977] reported hyperkeratinization and cellular degeneration (such as vacuolization and a multinucleated condition in cells of the malpighian layer) in the skin of guinea pigs, without any changes being observed in the dermis after exposure to a mixture of chlordane (67 mg/kg-day) and acetone through dermal painting for 90 days. Ambrose et al [1953] observed no local reactions in rats topically treated with 273 mg/ kg-day chlordane in ethyl alcohol for 4 days.…”

Section: Direct Effects On Skin (Sk: Dir)mentioning

confidence: 81%

“…Also, the reported LD 50 value for female rats treated with undiluted technical grade chlordane was 530 mg/kg [Gaines 1969]. Application of 50 mg chlordane in cottonseed oil to the skin of rats was lethal to all after daily application for 3 days, whereas identical application in ethyl alcohol caused no lethality [Ambrose et al 1953]. The dermal LD 50 values reported indicate that the vehicle in which chlordane was administered influenced its toxicity.…”

Section: Systemic Toxicity From Skin Exposure (Sk: Sys)mentioning

confidence: 99%

NIOSH skin notation (SK) profile: chlordane and technical grade chlordane [CAS No. 57-74-9; 12789-03-6].

Hudson¹,

Dotson²

2015

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“…At week 12 after the initial exposure, mice in all chlordane-treated groups had growth rates comparable to those of the controls. Maturing rats fed a diet containing more than 0.002% chlordane have been reported to display slightly depressed body weights compared to the controls (Ambrose et al, 1953).…”

Section: Discussionmentioning

confidence: 99%

“…Because of the nature of its chemical synthesis, technical chlordane is composed of several compounds (Ambrose et al, 1953). Thus, in our studies we decided to utilize alpha {cis) and gamma {trans) chlordane isomers, which were reported to have a °>9% minimum purity (Velsicol Chemical Corporation, personal communication).…”

Section: Introductionmentioning

confidence: 99%

Effects of chlordane isomers administered to female mice during the neonatal period

Talamantes

Jang

1977

Journal of Toxicology and Environmental Health

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In consideration of the influence that chlorinated hydrocarbon insecticides may exert on mammalian physiology, the present study was performed to investigate the effects of neonatal chlordane administration on body growth and endocrine development in female mice. Mice receiving 0.075 or 0.15 mg of alpha or gamma chlordane on day 2, 3, and 4 of life were observed to have growth rates depressed to varying extents depending on the concentration or the type of isomer that was utilized. Eye and vaginal opening in the neonatally treated mice were observed to be delayed to varying degrees, which were dependent on which isomer was used. The total effects observed in the neonatally treated mice were not found to reflect a dose-related response.

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Toxicological and Pharmacological Studies on Dihydrorotenone*

Cited by 10 publications

References 6 publications

Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor.

NIOSH skin notation (SK) profile: chlordane and technical grade chlordane [CAS No. 57-74-9; 12789-03-6].

Effects of chlordane isomers administered to female mice during the neonatal period

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