Toxicological and pharmacological profiling of organically and non-organically cultivated Cymbopogon citratus

Itankar, Prakash R.; Tauqeer, Mohammad; Dalal, Jayshree S

doi:10.1016/j.jaim.2017.04.002

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…The antidiabetic activity of the organic and non-organic cultivation of C. citratus leaves in streptozotocin-induced diabetic rats was evaluated. At the dose of 200 mg/kg, after 21 days of treatment, the organic plant aqueous extract exhibited a better antidiabetic activity than non-organic plant aqueous extract, both reducing blood glucose levels by 43.44% and 29.16%, respectively; while glibenclamide as positive control (10 mg/kg) caused a decreased of 58.56% (Itankar et al, 2019).…”

Section: Cymbopogon Citratusmentioning

confidence: 96%

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Vargas-Arana¹,

Salgado²,

Simirgiotis³

2023

BLACPMA

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Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyper-glycemia that is accompanied, to a greater or lesser extent, by alterations in the metabolism of carbohydrates, proteins and lipids. It is the leading cause of death in developed countries. Current antidiabetic drug treatments present several adverse effects for which it has started searching for new oral hypoglycemic agents from vegetal species. This review presents the medicinal plants from the Peruvian Amazon used in the treatment of diabetes and a systematic review of their hypoglycemic properties reported in the literature in the last twenty years used in different bibliographic databases. Seventy seven medicinal plants are reported as being used for the treatment of diabetes by Amazonian indigenous people, which 46.75% of species report hypoglycemic activity, evidencing that traditional knowledge is a great source for to searching antidiabetic drugs and also an alternative for future research.

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Section: Cymbopogon Citratusmentioning

confidence: 96%

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Vargas-Arana¹,

Salgado²,

Simirgiotis³

2023

BLACPMA

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“…Among these, the essential oils of the Cymbopogon genus, rich in citral, stand out for their significant antidiabetic and antioxidant properties in previous studies [ 15 , 16 ]. However, studies using the essential oil of Cymbopogon flexuosus (EOCF) in this area are scarce in the literature [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Lemongrass Essential Oil (Cymbopogon flexuosus) Supplementation on Diabetes in Rat Model

Júnior,

Aidar,

Silva

et al. 2024

Life

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(1) Background: Species of the genus Cymbopogon and its essential oil are known for their antioxidant and hypoglycemic effects. This study aimed to investigate the impact of the essential oil of Cymbopogon flexuosus (EOCF), and its major component, citral, on glycemic, lipid, antioxidant parameters, and oxidative stress in a type 1 diabetes (DM1) rat model. (2) Methods: Initially, EOCF was analyzed by Gas chromatography-mass spectrometry (GC-MS) and the antioxidant activity of EOCF and citral was evaluated. Next, male Wistar rats (3 months old, 200–250 g) induced with DM1 using Streptozotocin (STZ) were divided into four groups: negative control supplemented with an 80% Tween solution, two groups of animals supplemented with EOCF (32 mg/kg and 64 mg/kg) and with citral (32 mg/kg), and treated for 14 days. Measurements of blood glucose levels and body weight were taken; after euthanasia, biochemical markers, including lipid profile, uric acid, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were evaluated. (3) Results: The predominant compounds in EOCF were α-citral (53.21%) and neral (19.42%), constituting 72.63% citral. EOCF showed good antioxidant activity, significantly greater than citral. EOCF supplementation demonstrated a mitigating effect on glycemic, lipid, and hepatic abnormalities induced by DM1. (4) Conclusions: EOCF emerges as a promising therapeutic option for the management of DM1.

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Reduction of blood glucose by plant extracts and their use in the treatment of diabetes mellitus; discrepancies in effectiveness between animal and human studies

Furman

Candasamy

Bhattamisra

et al. 2020

Journal of Ethnopharmacology

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Toxicological and pharmacological profiling of organically and non-organically cultivated Cymbopogon citratus

Abstract: The study confirms that organically grown C. citratus is better in terms of nourishment, biological activity and safety measures.

Cited by 7 publications

References 14 publications

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Antidiabetic potential of medicinal plants from the Peruvian Amazon: A review

Influence of Lemongrass Essential Oil (Cymbopogon flexuosus) Supplementation on Diabetes in Rat Model

Reduction of blood glucose by plant extracts and their use in the treatment of diabetes mellitus; discrepancies in effectiveness between animal and human studies

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