Toxicological and metabolic studies of methyl n-butylketone, 2,5-hexanedione, and 2,5-hexanediol in male rats

Eben, A.; Flucke, Winfried; Mihail, Florin; Thyssen, J.; Kimmerle, Georg

doi:10.1016/0147-6513(79)90012-5

Cited by 16 publications

(2 citation statements)

References 10 publications

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“…From Table I, it appears that 2Hol is readily formed after ip administration and that 5H2H is formed only at higher doses [Abdel-Rahman et al, 1976;DiVincenzo et al, 19761. In contrast, 2Hol could be found in blood or plasma only after rather high oral doses [Eben et a]., 1979;Pilon et al, 19861. Since the absorption by the gastro-intestinal tract is almost loo%, the doses administered intraperitoneally and orally are comparable [Divincenzo et al, 1977, 19781. This may indicate that in the case of oral administration the oxidation of MBK is preferred, while the reduction to 2Hol is more important after ip administration; 2Hol can be oxidized into 25HDio1, which in turn can be oxidized via 5H2H into 25HD (Fig.…”

Section: Distribution Biotransformation and Excretionmentioning

confidence: 90%

“…Krasavage et al [I9801 suggested that a threshold serum concentration of approximately 50 mg 25HD/1 should be present in rats before severe clinical signs of neuropathy will be observed. However, Eben et al [1979] found no clear signs of neuropathy, although their rats had 25HD blood levels that exceeded 100 mg/l nearly every day for 40 weeks. Besides, Krasavage et al [1980] observed an approximately 12 times higher potency for orally administered MBK compared with n-hexane in producing hindlimb dragging in rats.…”

Section: Feasibility Of Biological Monitoringmentioning

confidence: 95%

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Critical review of the toxicity of methyl n‐butyl ketone: Risk from occupational exposure

Bos¹,

Mik²,

Bragt³

1991

American J Industrial Med

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Methyl n-butyl ketone (MBK) was considered rather harmless until an outbreak of peripheral neuropathy occurred in 1973 among workers exposed to MBK. MBK easily penetrates the skin; pulmonary retention is approximately 80-85% in man. Distribution is widespread with highest levels in blood and liver; MBK also reaches the fetal tissues. MBK metabolism probably depends on the route of exposure, and is very similar to that of n-hexane. The critical organ is the nervous system. These effects find expression as peripheral neuropathy, with potential for serious effects of the central nervous system. From the viewpoint of neurotoxicity, 2,5-hexanedione is the most important metabolite. The neurotoxicity is potentiated by several compounds, while MBK itself potentiates the toxicity of other chemicals. From animal experiments, a no-adverse-effect level (NAEL) could not be established. Peripheral neuropathy may develop in workers exposed to only a few ppm of MBK. The difference in the Occupational Exposure Limits for MBK and n-hexane, as established by several organizations, is questioned in view of the neurotoxic effects of these substances.

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Section: Distribution Biotransformation and Excretionmentioning

confidence: 90%

Section: Feasibility Of Biological Monitoringmentioning

confidence: 95%

Critical review of the toxicity of methyl n‐butyl ketone: Risk from occupational exposure

Bos¹,

Mik²,

Bragt³

1991

American J Industrial Med

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Ketones of Six to Thirteen Carbons

O’Donoghue

2023

Patty's Toxicology

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Ketones of carbon number 6–13 are important commercial and industrial materials. Their primary use is as solvents that find use in numerous products and industrial applications. Due to their volatility, environmental regulations have been directed at restricting emissions, particularly to the atmosphere. A number of the ketones discussed in this chapter not only can undergo photochemical transformations that contribute to their abiotic degradation but may also contribute to the formation of smog. Regulations limiting or prohibiting release of materials that may contribute to smog formation are leading to reductions in the use of some of these materials. The ketones covered in this chapter are mainly of concern due to inhalation and dermal exposure routes. Acute exposure to high vapor concentrations of these materials may result in narcosis; however, such exposures are rare except in cases of accidents. Repeated exposure to certain of these ketones may result in peripheral neuropathy or hepatic effects.

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Ketones of Six To Thirteen Carbons

Topping¹,

Morgott²,

O’Donoghue³

2001

Patty's Toxicology

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Ketones of carbon number 6–13 are important commercial and industrial materials. Their primary use is as solvents that find use in numerous products and industrial applications. Due to their volatility, environmental regulations have been directed at restricting emissions, particularly to the atmosphere. A number of the ketones discussed in this chapter can undergo photochemical transformations that contribute to their abiotic degradation but may also contribute to the formation of smog. Regulations limiting or prohibiting release of materials that may contribute to smog formation are leading to reductions in the use of some of these materials. As for the short‐chain ketones discussed in Chapter 75, the ketones covered in this chapter are mainly of concern due to inhalation and dermal exposure routes. Acute exposure to high vapor concentrations of these materials may result in narcosis; however, such exposures are rare except in cases of accidents. Low levels of exposure to many of these ketones can be expected in the environment and through endogenous exposure because ketones are common substrates for many of the enzymes associated with intermediary metabolism in organisms from bacteria to man.

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Toxicological and metabolic studies of methyl n-butylketone, 2,5-hexanedione, and 2,5-hexanediol in male rats

Cited by 16 publications

References 10 publications

Critical review of the toxicity of methyl n‐butyl ketone: Risk from occupational exposure

Critical review of the toxicity of methyl n‐butyl ketone: Risk from occupational exposure

Ketones of Six to Thirteen Carbons

Ketones of Six To Thirteen Carbons

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