Toxicologic investigations on Delnav®

NIOSH skin notation (SK) profile: dioxathion [CAS No. 78-34-2].

“…No toxicokinetic data on humans or animals and no case reports, epidemiological studies, or repeated-dose, subchronic, or chronic toxicity studies in animals were identified that evaluated the potential of dioxathion to be absorbed through the skin or to cause systemic effects following dermal exposure. Although a predictive model indicates that dioxathion has low potential to be absorbed through the skin and be systemically available, acute dermal toxicity studies in rats and rabbits [Frawley et al 1963;Gaines 1969] indicate that dioxathion is absorbed through the skin, is systemically available, and can be fatal at low doses following dermal exposure. No in vitro tests, case reports, or standard skin irritation tests were identified that evaluated the potential of dioxathion to produce direct effects on the skin.…”

“…The dermal LD 50 value for m-xylene, for which data were available, is 14.1 milliliters per kilogram body weight (mL/kg, corresponding to 12,126 mg/ kg) in rabbits [Smyth et al 1960], indicating that the observed value for dioxathion was not due to xylene toxicity. In rabbits, dermal LD 50 values for a commercial preparation of dioxathion containing 70% cis and trans isomers (present in the ratio of 1:2, respectively) were reported as 106 mg/kg in the absence of a solvent and 100 mg/ kg applied in xylene as a solvent (in rabbits) and 63 and 235 mg/kg of the commercial preparation of dioxathion applied in xylene (in female and male rats, respectively) [Frawley et al 1963]. No case reports or epidemiological studies or animal repeated-dose, subchronic, or chronic toxicity studies were identified that evaluated the potential of dioxathion to cause systemic effects following dermal exposure.…”

Phosdrin [MAK Value Documentation in German language, 1972]

“…Die LD 50 von technischem Phosdrin bei oraler Verabreichung war bei Ratten zwischen 3,7 und 7,0 mg/kg [37][38][39][40][41][42][43], bei Mäusen zwischen 4,3 und 12,3 mg/kg [40,44] und Küken 7,52 mg/kg [45]. Die Symptome traten rasch auf, und der Eintritt des Todes erfolgte stets in einer Stunde [38,40,41] [42], Delnav [43] und Ruelene [51] in Tierversuchen nicht festgestellt werden.…”

“…Die Symptome traten rasch auf, und der Eintritt des Todes erfolgte stets in einer Stunde [38,40,41] [42], Delnav [43] und Ruelene [51] in Tierversuchen nicht festgestellt werden. Unterschiedliche Ergebnisse wurden mit Phenothiazinen gefunden: Potenzierung mit Chlorpromazin [52], keine Potenzierung mit Promazin [53].…”

Malathion [MAK Value Documentation in German language, 1973]

“…Die akute orale LD 50 von Malathion wurde für Ratten mit 250-4700 mg/kg [43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58], für Mäuse mit 2700-4059 mg/kg [54][55], für Hühner mit� 850 mg/kg [54], für Hunde � 4000 mg/kg [52], für Kälber mit 80 mg/kg [54], für Rinder 150-560 mg/kg [54,59] und für Schafe mit 100-150 mg/kg [59] angegeben. Die LD 50 [86][87][88][89].…”