2002
DOI: 10.1016/s0048-3575(02)00149-9
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Toxicologic implications of the metabolism of thiram, dimethyldithiocarbamate and carbon disulfide mediated by hepatic cytochrome P450 isozymes in rats

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Cited by 17 publications
(8 citation statements)
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“…Repulsion between the fractional positive charge developed on N and C leads to cleavage of the N–C bond, forming dialkyl amine and CS 2 (Joris et al , ). Dimethyldithiocarbamate and CS 2 are mainly responsible for the hepatotoxicity (Dalvi et al , ). The probable pathway for the degradation of thiram is shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Repulsion between the fractional positive charge developed on N and C leads to cleavage of the N–C bond, forming dialkyl amine and CS 2 (Joris et al , ). Dimethyldithiocarbamate and CS 2 are mainly responsible for the hepatotoxicity (Dalvi et al , ). The probable pathway for the degradation of thiram is shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…In detail, among EBDCs were mancozeb, zineb and metiram, and among DMDCs were thiram and ziram. It was previously documented that these organosulfur fungicides were closely associated with the increases in ALT and AST in humans and animals, which indicated damages to hepatic function 54 55 56 .…”
Section: Discussionmentioning
confidence: 97%
“…Of the different metabolites formed, dimethyl dithiocarbamate and oxons seem to persist for a longer time period and are reported to be highly toxic. [4,22] The metabolites 2(N,Ndimethyl amino)thiazoline carboxylic acid and 2-thioxo-4-thiazolidine identified in radish leaf and root and tomato fruit are also reported to be toxic and have been identified in rat metabolism also. [23] The said metabolites independently or synergistically enhance the toxicity of the pesticide.…”
Section: Discussionmentioning
confidence: 99%
“…[21] DMDTC and CS 2 are mainly responsible for the hepatotoxicity. [4] The probable pathway for the fate of DMDTC in acidic conditions is shown in Figure 4.…”
Section: Identification Of Degradation Products For Tomato Fruit (T 1mentioning
confidence: 99%
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