Toxicokinetics and toxic effects of a Chinese PFOS alternative F-53B in adult zebrafish

Wu, Yongming; Deng, Mi; Jin, Yuanxiang; Liu, Xin; Mai, Zhaohuan; You, Hailin; Mu, Xiyan; He, Xiaoli; Al-harthi, Reem; Kostyniuk, Daniel J.; Yang, Chunyan; Tu, Wenqing

doi:10.1016/j.ecoenv.2019.01.010

Cited by 52 publications

(18 citation statements)

References 35 publications

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“…In larvae, the exposure to F-53B resulted again in a dose dependent decrease of GSH content [312,318]. Instead, the data relating to adult organisms show a differential response between sexes, with females presenting no significant difference in GSH content in liver of treated specimens compared to the controls [317].…”

Section: Biochemical Datamentioning

confidence: 93%

“…Exposure to PFOS alternatives gave mixed results. In fact, a decrease in lipid damage was highlighted in liver and larvae of zebrafish after F-53B exposure [317,318] but there was an increase in zebrafish embryos exposed to 6:2 FTAB [311].…”

Section: Chemical Datamentioning

confidence: 95%

“…Even in the case of CAT, there are different effects between F-53B and 6:2 FTAB. The first significantly decreases the CAT activity in zebrafish larvae and adults [312,317,318], the second produces incremental variations in treated zebrafish embryos [311]. In chicken, CAT activity was not significantly affected by the treatments with F-53B [319].…”

Section: Biochemical Datamentioning

confidence: 99%

“…Again, alternatives to PFOS produce variable effects, with F-53B that significantly induce GPx in zebrafish larvae and adults [312,317,318], and 6:2 FTAB that instead decreases the GPx activity in treated zebrafish embryos [311].…”

Section: Biochemical Datamentioning

confidence: 99%

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PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in the Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders, and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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Section: Biochemical Datamentioning

confidence: 93%

Section: Chemical Datamentioning

confidence: 95%

Section: Biochemical Datamentioning

confidence: 99%

Section: Biochemical Datamentioning

confidence: 99%

See 2 more Smart Citations

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Exposure to PFOS alternatives gave mixed results. In fact, a decrease in lipid damage was highlighted in liver and larvae of zebrafish after F-53B exposure [314,315] but there was an increase of zebrafish embryos exposed to 6:2 FTAB [308].…”

Section: Chemical Datamentioning

confidence: 95%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato¹,

Corrà²,

Belli̇o³

et al. 2020

Preprint

View full text Add to dashboard Cite

Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

show abstract

Omics Approaches in Toxicological Studies

Mortimer

Fang

Zhou

et al. 2022

Advances in Toxicology and Risk Assessment of Nanomaterials and Emerging Contaminants

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Toxicokinetics and toxic effects of a Chinese PFOS alternative F-53B in adult zebrafish

Cited by 52 publications

References 35 publications

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Omics Approaches in Toxicological Studies

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