Toxicokinetics and bioaccumulation characteristics of bisphenol analogues in common carp (Cyprinus carpio)

Wang, Qiang; Chen, Meng; Qiang, Liwen; Wu, Wei; Yang, Jing; Zhu, Lingyan

doi:10.1016/j.ecoenv.2020.110183

Cited by 25 publications

(24 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparatively, conjugated BPA accounted for less percentage (mean 79%, range 63–87%) of the total BPA in marine organisms here. Wang et al investigated the toxicokinetics of eight BPs in common carp living in fresh waters spiked with BPs, and reported that the percentage of free-form BPs in the whole body of carp ranged from 21% (BPS) to 48% (BPAP) . Comparatively, the fractions of free-form BPAF, BPS, and BPZ were higher in marine organisms here than those in the study of Wang et al This discrepancy is expected, and different BP exposure sources could explain this.…”

Section: Resultsmentioning

confidence: 69%

“…Wang et al investigated the toxicokinetics of eight BPs in common carp living in fresh waters spiked with BPs, and reported that the percentage of free-form BPs in the whole body of carp ranged from 21% (BPS) to 48% (BPAP) . Comparatively, the fractions of free-form BPAF, BPS, and BPZ were higher in marine organisms here than those in the study of Wang et al This discrepancy is expected, and different BP exposure sources could explain this. Marine organisms were exposed to BPs through diet in the ocean, which is minimal for the common carp.…”

Section: Resultsmentioning

confidence: 69%

“…24,28 Recently, Wang et al conducted laboratory experiments to investigate the presence of free-form and conjugated BPs in common carp, which were living in fresh waters spiked with BPs. 34 To the best of our knowledge, limited studies have investigated the relative concentrations of free-form BPs and conjugated BPs in wild animals, such as marine organisms.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Many studies have reported the occurrence and concentrations of the free-form BPA in seawater and marine organisms. , However, the occurrence of BPA alternatives in marine organisms, especially those from China, is still not well characterized. Several studies have examined free-form and conjugated BPA in human urine. , Recently, Wang et al conducted laboratory experiments to investigate the presence of free-form and conjugated BPs in common carp, which were living in fresh waters spiked with BPs . To the best of our knowledge, limited studies have investigated the relative concentrations of free-form BPs and conjugated BPs in wild animals, such as marine organisms.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Occurrence of Free-Form and Conjugated Bisphenol Analogues in Marine Organisms

Zhao

et al. 2021

Environ. Sci. Technol.

View full text Add to dashboard Cite

Upon exposure, most bisphenol analogues (BPs) are rapidly metabolized to BP conjugates in organisms. Monitoring studies on BPs in aquatic organisms have been mainly focused on free-form BPs. However, the relative amount of conjugated BPs in organisms is still not well known, especially in marine organisms. In this study, we collected marine organisms (13 species; n = 74), as well as seawater (n = 15), from East China Sea, and analyzed them for bisphenol A (BPA) and its eight analogues. In seawater, BPA was the predominant BP (mean ± standard deviation (SD), 18 ± 9.7 ng/L), followed by bisphenol S (BPS; 3.7 ± 2.8 ng/L), bisphenol F (BPF; 0.31 ± 0.17 ng/L), and bisphenol AF (BPAF; 0.24 ± 0.15 ng/L). The whole body of each marine organism was used for BP analysis in this study. BPA (mean 3.8 ng/g, range 1.2−7.7 ng/g) and BPS (1.5 ng/g, 0.19−6.1 ng/g) were still the predominant BPs in marine organisms without hydrolysis. After enzymatic hydrolysis treatment, mean concentrations of BPs increased 1.8 (BPS)−3.7 (BPA) times in marine organisms. Correspondingly, on average, 74, 52, 49, 48, and 45% of BPA, bisphenol Z, BPF, BPS, and BPAF were present in conjugated forms, respectively, in marine organisms. Moreover, bioaccumulation and biomagnification of BPs were evaluated using pooled marine organism samples. We first found that the mean log BAF values of BPs increased 0.091 (BPAF) to 0.31 (BPA) times in marine organisms after hydrolysis. Overall, this study first determines the amount of BPs present in conjugated forms in marine organisms, which are helpful for better understanding the occurrence of BPs in organisms.

show abstract

Section: Resultsmentioning

confidence: 69%

Section: Resultsmentioning

confidence: 69%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Occurrence of Free-Form and Conjugated Bisphenol Analogues in Marine Organisms

Zhao

et al. 2021

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…For example, EDCs can transfer from the polluted environment to the raw materials used as food ingredients, or from contaminated soil, water, or atmospheric deposition from nearby industrial activity [ 19 , 20 ]. Moreover, animals fed with contaminated feed can bioaccumulate EDCs in their adipose tissue, because of their good lipophilicity, and then can eliminate them through major excretion routes, including milk [ 21 , 22 , 23 ]. Additionally, all storage containers and processing machines used along the production chain can be sources of contamination if they are made with materials that can leak EDCs into the food in contact with them.…”

Section: Introductionmentioning

confidence: 99%

Determination of 20 Endocrine-Disrupting Compounds in the Buffalo Milk Production Chain and Commercial Bovine Milk by UHPLC–MS/MS and HPLC–FLD

Pisciottano

Guadagnuolo

Busico

et al. 2022

Animals

View full text Add to dashboard Cite

Bisphenol A (BPA) and some of its analogues are well known as endocrine-disrupting chemicals (EDCs), i.e., compounds that can affect the physiological hormonal pathways in both animals and humans, causing adverse health effects. The intake of these substances through diet represents a public concern, compounded by the scarce data in the literature about contamination levels in food. In the framework of a research project, funded by the Italian Ministry of Health, we determined the contamination levels of BPA and 19 EDCs in the production chain of buffalo milk, analysing feed, drinking water, buffalo milk, and blood sera. Overall, 201 feed, 9 feed additive, 62 drinking water, 46 milk, and 190 blood serum samples were collected from 10 buffalo farms in the Campania region, Southern Italy, between 2019 and 2020, and analysed. Moreover, 15 retail bovine milk samples packaged both in Tetra Pak and in PET were analysed to further evaluate consumers’ exposure to EDCs. The results of our work showed no contamination by EDCs in drinking water samples, whereas in 43% of all of the other samples from the farms at least one bisphenol was detected. The most abundant bisphenol detected was BPA (32% of the samples from the farms and 80% of the retail milk samples), thus proving that this compound is still widely used for plastic production.

show abstract

Profile, Tissue Distribution, and Time Trend of Bisphenol Plastic Additives in Freshwater Wildlife of the Pearl River Ecosystem, China

Peng

Zhou

Chen

et al. 2023

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Plastic‐related contaminants in the environment have attracted increasing attention, with plastic pollution becoming a serious issue globally. The present study investigated the potential bioaccumulation and biotransfer of bisphenol (BP) compounds that are widely added in various products such as plastics and other products in a freshwater ecosystem, China. Among commonly applied 14 BP analogues, bisphenol A (BPA), bisphenol F (BPF), and bisphenol S (BPS) were predominant, representing 64%–100% of the total concentrations of BPs (ΣBPs) in freshwater wildlife. Both the concentrations and analogue profiles in the fish showed seasonal differences and species dependence. Higher BP concentrations were observed in fish collected during the dry season than the wet season. Higher percentages of non‐BPA analogues (e.g., BPS and BPF) were observed in fish collected during the wet season. Pelagic species accumulated notably higher levels of BPs than midwater and bottom species. The liver generally contained the highest ΣBPs, followed successively by the swim bladder, belly fat, and dorsal muscle. The analogue profile also showed some differences among tissues, varying by species and season. Lower ΣBPs but higher percentages of non‐BPA analogues were observed in female than male common carp. Time trends of the BPA concentration in fish varied by species, probably related to habitats and diets of the fish. Habitats, feeding behaviors, and trophic transfer may have significant impacts on exposure of wildlife to BPs in natural ecosystems. The BPs did not demonstrate strong potential for bioaccumulation. More research is warranted about metabolism and transgenerational transfer of BPs in wildlife to fully reveal the bioaccumulation and consequently ecological risks of these chemicals in the environment. Environ Toxicol Chem 2023;00:1–13. © 2023 SETAC

show abstract

Toxicokinetics and bioaccumulation characteristics of bisphenol analogues in common carp (Cyprinus carpio)

Cited by 25 publications

References 39 publications

Occurrence of Free-Form and Conjugated Bisphenol Analogues in Marine Organisms

Occurrence of Free-Form and Conjugated Bisphenol Analogues in Marine Organisms

Determination of 20 Endocrine-Disrupting Compounds in the Buffalo Milk Production Chain and Commercial Bovine Milk by UHPLC–MS/MS and HPLC–FLD

Profile, Tissue Distribution, and Time Trend of Bisphenol Plastic Additives in Freshwater Wildlife of the Pearl River Ecosystem, China

Contact Info

Product

Resources

About