Toxicogenic effects of the mushroom Ganoderma lucidum on human liver and kidney tumor cells and peripheral blood lymphocytes

Mendonça, Débora Elisa Antunes de; Godoy, Mariane Aparecida Franco de; Lucredi, Naiara Cristina; Comar, Jurandir Fernando; Almeida, Igor Vivian de; Vicentini, Verônica Elisa Pimenta

doi:10.1016/j.jep.2023.116226

Cited by 3 publications

(1 citation statement)

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“…The liver and kidney being major organs involved in drug metabolism and elimination are prone to toxic effect of xenobiotics [7] , [8] The ethanolic extracts of A. coriaria have been reported to contain abundant tannins and terpenoids. Yet studies have reported that some tannins and terpenoids are potentially nephrotoxic and can cause interstitial nephritis, renal tubular necrosis, acute kidney injury, oxalate nephropathy and glomerulonephritis [11] , [13] . Hence, it is highly probable that the observed nephrotoxicity is due to terpenoids and tannins present in this plant ().…”

Section: Discussionmentioning

confidence: 99%

Acute and subacute toxicity profile of ethanolic stem bark extract of Albizia coriaria Welw. ex Oliv. in Wistar albino rats

Obakiro,

Kiyimba,

Owor

et al. 2024

Toxicology Reports

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Section: Discussionmentioning

confidence: 99%

Acute and subacute toxicity profile of ethanolic stem bark extract of Albizia coriaria Welw. ex Oliv. in Wistar albino rats

Obakiro,

Kiyimba,

Owor

et al. 2024

Toxicology Reports

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Identification of anti-fibrotic and pro-apoptotic bioactive compounds from Ganoderma formosanum and their possible mechanisms in modulating TGF-β1-induced lung fibrosis

Cheng,

Chong,

Hsieh

et al. 2024

Journal of Ethnopharmacology

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Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action

Ahmad

Zeyaullah

et al. 2023

Nutrients

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Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries. It is currently used as a nutraceutical and functional food owing to its major bioactive compounds, polysaccharides and triterpenoids. G. lucidum exhibits a broad range of hepatoprotective impacts in various liver disorders, such as hepatic cancer, nonalcoholic fatty liver disease (NAFLD), alcohol-induced liver disease, hepatitis B, hepatic fibrosis, and liver injury induced by carbon tetrachloride (CCl4) and α-amanitin. G. lucidum protects the liver through a broad range of mechanisms that include the modulation of liver Phase I and II enzymes, the suppression of β-glucuronidase, antifibrotic and antiviral actions, the regulation of the production of nitric oxide (NO), the maintenance of hepatocellular calcium homeostasis, immunomodulatory activity, and scavenging free radicals. G. lucidum could signify an encouraging approach for the management of various chronic hepatopathies, and its potential mechanisms make it a distinctive agent when used alone or with other drugs and applied as a functional food, nutraceutical supplement, or adjuvant to modern medicine. This review summarizes the hepatoprotective properties of G. lucidum with its various mechanisms of action on different liver ailments. Biologically active substances derived from G. lucidum are still being studied for their potential benefits in treating different liver ailments.

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Toxicogenic effects of the mushroom Ganoderma lucidum on human liver and kidney tumor cells and peripheral blood lymphocytes

Cited by 3 publications

References 38 publications

Acute and subacute toxicity profile of ethanolic stem bark extract of Albizia coriaria Welw. ex Oliv. in Wistar albino rats

Acute and subacute toxicity profile of ethanolic stem bark extract of Albizia coriaria Welw. ex Oliv. in Wistar albino rats

Identification of anti-fibrotic and pro-apoptotic bioactive compounds from Ganoderma formosanum and their possible mechanisms in modulating TGF-β1-induced lung fibrosis

Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action

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