Toxico-epidemiology of acute poisoning; an exploratory study from a tertiary care hospital in South India along with global comparisons and solutions

Nair, Santhanu Jagannath; Sujatha, Chintha; P, Selvarajan Chettiar K; Sasikala, K.

doi:10.1016/j.jflm.2021.102247

Cited by 6 publications

(6 citation statements)

References 41 publications

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“… 1 , 2 Paracetamol was also the single most used drug for acute poisoning in India. 3 Paracetamol poisoning can be fatal owing to its hepatotoxic and nephrotoxic nature. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

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Successful management of delayed presentation of massive paracetamol overdose in a resource‐limited setting: A case report from Nepal

Lamichhane¹,

Pokhrel²,

Bhandari

et al. 2022

Clinical Case Reports

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We present a case of self‐poisoning with a massive dose of paracetamol by a young Nepalese female patient who presented late to our emergency department. This report highlights the successful management of the patient with the extended use of N‐acetylcysteine over 4 days and continuous supportive therapy as required. The case is an example of the management of delayed presentation of a massive paracetamol poisoning in a resource‐limited setting, where intensive care units and hemodialysis facilities are not easily available. However, when available, massive poisoning should always be managed in continuous monitoring units under the expertise of a toxicologist.

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“… 1 , 2 Paracetamol was also the single most used drug for acute poisoning in India. 3 Paracetamol poisoning can be fatal owing to its hepatotoxic and nephrotoxic nature. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

“…1,2 Paracetamol was also the single most used drug for acute poisoning in India. 3 Paracetamol poisoning can be fatal owing to its hepatotoxic and nephrotoxic nature. 4,5 Acute ingestion of at least 7.5-10 gms in adults or 150-200 mg/kg in children above 6 years is considered a toxic dose of paracetamol, which is likely to produce hepatotoxicity.…”

mentioning

confidence: 99%

Successful management of delayed presentation of massive paracetamol overdose in a resource‐limited setting: A case report from Nepal

Lamichhane¹,

Pokhrel²,

Bhandari

et al. 2022

Clinical Case Reports

View full text Add to dashboard Cite

show abstract

“…Studies originating from urban centers exhibit a pattern much similar to the Western World or developed countries whereby the most commonly employed agents of poisoning are drugs, including pharmacological agents, e.g., over-the-counter prescription drugs and drugs of abuse. 3 , 5 Drugs are responsible in as many as 46.4% and agricultural pesticides are responsible in a mere 4.3% of cases. 3 Data suggests that educational and socioeconomic status may also affect the choice of poisoning agent, with more educated and more affluent people opting for pharmacological over agricultural agents.…”

mentioning

confidence: 99%

“… 3 Data suggests that educational and socioeconomic status may also affect the choice of poisoning agent, with more educated and more affluent people opting for pharmacological over agricultural agents. 2 , 5 Even though agricultural poisons, including insecticides and pesticides, are responsible for only a minority of poisonings in urban settings, they continue to be associated with the majority of deaths. 3 Further, increasing use of newer drugs of abuse (e.g., designer drugs) in urban population, may complicate the clinical picture as they are more difficult to diagnose because they do not fit in specific toxidromes and are not detected in routine urine and blood toxicology screens.…”

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confidence: 99%