Toxicity, uptake, and accumulation of nano and bulk cerium oxide particles in Artemia salina

David, Einstein Mariya; Royam, Madhav Madurantakam; Sekar, Suresh Kumar Rajamani; Bhuvaneshwari, M.; Soman, Swathy Jalaja; Mukherjee, Amitava; Chandrasekaran, Natarajan

doi:10.1007/s11356-017-9975-4

Cited by 19 publications

(3 citation statements)

References 70 publications

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“…The dissolution of Ln-based NPs might occur at nano-bio interface and be an important cause of toxic effects [11,[83][84][85]. Other particle-specific effects include physical effects after ingestion by, or adsorption on, the organism [86][87][88], induction of oxidative stress [89,90], and membrane damage [71,[91][92][93][94], along with entrapment of unicellular organisms into NPs agglomerates [28,77].…”

Section: Toxicity To Aquatic Biotamentioning

confidence: 99%

Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis

et al. 2020

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Lanthanides (Ln), applied mostly in the form of nanoparticles (NPs), are critical to emerging high-tech and green energy industries due to their distinct physicochemical properties. The resulting anthropogenic input of Ln and Ln-based NPs into aquatic environment might create a problem of emerging contaminants. Thus, information on the biological effects of Ln and Ln-based NPs is urgently needed for relevant environmental risk assessment. In this mini-review, we made a bibliometric survey on existing scientific literature with the main aim of identifying the most important data gaps on Ln and Ln-based nanoparticles’ toxicity to aquatic biota. We report that the most studied Ln for ecotoxicity are Ce and Ln, whereas practically no information was found for Nd, Tb, Tm, and Yb. We also discuss the challenges of the research on Ln ecotoxicity, such as relevance of nominal versus bioavailable concentrations of Ln, and point out future research needs (long-term toxicity to aquatic biota and toxic effects of Ln to bottom-dwelling species).

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Section: Toxicity To Aquatic Biotamentioning

confidence: 99%

Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis

et al. 2020

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“…In fact, it is known that a smaller sphere diameter results in a greater chance of reaching the cytoplasm of cells and causes imbalances in metabolism with altered enzymes and transcripts [53,66]. These data suggested the probable existence of a size and concentration range that, within which, antioxidant systems with which microcrustaceans are equipped, including catalase, superoxide dismutase, and glutathione peroxidase, can eliminate radical molecules [74,75].…”

Section: Discussionmentioning

confidence: 99%

Sublethal Effects of Polystyrene Nanoplastics on the Embryonic Development of Artemia salina (Linnaeus, 1758)

Contino,

Ferruggia,

Indelicato

et al. 2023

Animals

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Currents, wave motion, solar radiation, and abrasion are mechanisms responsible for the degradation of large plastic artifacts and contribute to the dispersion of micro and nanoplastics into aquatic ecosystems, which are, currently, the most dangerous threats due to their invisibility and persistence. The present work evaluated the possible lethal and sublethal effects of amino-modified polystyrene nanoplastics (nPS-NH2) with diameters of 50 nm and 100 nm on Artemia salina (A. salina), an organism at the base of the trophic chain of the aquatic system, using a widely used model for the analysis of embryotoxicity from environmental pollutants. For this purpose, after evaluating the biodistribution of nanoplastics in the body of the tested animals, several endpoints such as anomalies, apoptosis, and ROS production were assessed. In addition, particular attention was dedicated to evaluating the correlation between toxicity and the particle size tested. The results reported that, despite the absence of a lethal impact, several sublethal effects involving gut and body size malformations, as well as the enhancement of apoptosis and oxidative stress in relation to an increase in tested concentration and a decrease in nanoparticle size.

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“…Herein, to realize the combination of ferroptosis therapy and p53 activation, p53 activator peptide (PMI) and the free-radical generating nanoparticle CeO 2 were selected to induce ferroptosis in cancer cells ( Sugantharaj David et al, 2017 ). Based on metal-organic coordination and a “one-pot” self-assembly strategy, a bifunctional metal-organic supramolecular (Nano-PMI@CeO 2 ) was constructed, in which CeO 2 functioned as the inorganic building block of supramolecules, while the peptide-gold precursor polymer formed based on gold–sulfur bond functioned as the inorganic building block.…”

Section: Introductionmentioning

confidence: 99%

Assembling p53 Activating Peptide With CeO2 Nanoparticle to Construct a Metallo-Organic Supermolecule Toward the Synergistic Ferroptosis of Tumor

Wang

He²,

Zhang³

et al. 2022

Front. Bioeng. Biotechnol.

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Inducing lipid peroxidation and subsequent ferroptosis in cancer cells provides a potential approach for anticancer therapy. However, the clinical translation of such therapeutic agents is often hampered by ferroptosis resistance and acquired drug tolerance in host cells. Emerging nanoplatform-based cascade engineering and ferroptosis sensitization by p53 provides a viable rescue strategy. Herein, a metallo-organic supramolecular (Nano-PMI@CeO2) toward p53 restoration and subsequent synergistic ferroptosis is constructed, in which the radical generating module-CeO2 nanoparticles act as the core, and p53-activator peptide (PMI)-gold precursor polymer is in situ reduced and assembled on the CeO2 surface as the shell. As expected, Nano-PMI@CeO2 effectively reactivated the p53 signaling pathway in vitro and in vivo, thereby downregulating its downstream gene GPX4. As a result, Nano-PMI@CeO2 significantly inhibited tumor progression in the lung cancer allograft model through p53 restoration and sensitized ferroptosis, while maintaining favorable biosafety. Collectively, this work develops a tumor therapeutic with dual functions of inducing ferroptosis and activating p53, demonstrating a potentially viable therapeutic paradigm for sensitizing ferroptosis via p53 activation. It also suggests that metallo-organic supramolecule holds great promise in transforming nanomedicine and treating human diseases.

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Toxicity, uptake, and accumulation of nano and bulk cerium oxide particles in Artemia salina

Cited by 19 publications

References 70 publications

Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis

Potential Hazard of Lanthanides and Lanthanide-Based Nanoparticles to Aquatic Ecosystems: Data Gaps, Challenges and Future Research Needs Derived from Bibliometric Analysis

Sublethal Effects of Polystyrene Nanoplastics on the Embryonic Development of Artemia salina (Linnaeus, 1758)

Assembling p53 Activating Peptide With CeO2 Nanoparticle to Construct a Metallo-Organic Supermolecule Toward the Synergistic Ferroptosis of Tumor

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